Results 81 to 90 of about 11,349 (193)

Heterogeneous catalysis for azide-alkyne bioconjugation in solution via spin column: Attachment of dyes and saccharides to peptides and DNA

BioTechniques, 2015
Copper-catalyzed azide-alkyne cycloaddition (CuAAC) “click” chemistry is widely used and has demonstrated particular utility for bio-orthogonal conjugation reactions.
Jeremy Kallick, Sarah Harris, Andrew K. Udit, Michael G. Hill   +3 more
doaj   +1 more source

2-Deoxyglucose Dendrimer-Enabled Niclosamide Delivery to FRβ-Expressing Macrophages Alleviates Endometriosis Progression and Associated Hyperalgesia. [PDF]

Adv Healthc Mater
A folic acid (FA)‐conjugated 2‐deoxyglucose dendrimer selectively targets FRβ+ macrophages in endometriotic lesions, enabling precise intracellular delivery of niclosamide. This nonhormonal nanomedicine enhances drug solubility, provides controlled intracellular release, suppresses lesion growth, reduces inflammation and pain, and establishes FRβ ...
Dhull A, Shi M, Harvey ME, Page TM, Sharma R, Goody KJ, Dar AI, Moawad NS, Sirohi VK, Cooke PS, Hayashi K, Sharma A.   +11 more
europepmc   +2 more sources

Multicomponent reactions for DNA‐encoded library construction: Scaffold diversity and reaction engineering strategies

Bulletin of the Korean Chemical Society, EarlyView.
Abstract DNA‐encoded libraries (DELs) enable large‐scale screening for hit identification, but accessing sp3‐rich, three‐dimensional chemotypes beyond flat, aromatic scaffolds remains challenging. Multicomponent reactions (MCRs) assemble such complexity from simple building blocks in a single step, and reaction‐engineering strategies have extended on ...
Jimin Moon, Hyemin Yoon, Kang Ju Lee, Hyun Jin Kim   +3 more
wiley   +1 more source

Held out wings RNA binding activity in the cytoplasm during early spermatogenesis

Communications Biology
Held out wings (HOW) is an RNA-binding protein essential for spermatogenesis in Drosophila melanogaster. HOW is a signal transduction and activation of RNA (STAR) protein, regulating post-transcriptional gene expression.
Michaela Agapiou, Karl Norris, Tayah Hopes, Eilidh Ward, Fruzsina Hobor, Amanda Bretman, Thomas A. Edwards, Julie L. Aspden   +7 more
doaj   +1 more source

Efficient One-Pot Synthesis of Triazole-Linked Morpholinone Scaffolds by CuAAC in the Presence of 18-Crown-6

SynOpen, 2018
A range of bis-heterocyclic derivatives based on novel morpholinone­ and triazole heterocycles was prepared from iodo-morpholinone­. The key step in our strategy is a one-pot procedure based upon copper-catalysed alkyne-azide cycloaddition (CuAAC) from ...
A. Mayooufi, M. Romdhani-Younes, J. Thibonnet   +2 more
doaj   +1 more source

Fullerene-Attached Polymeric Homogeneous/Heterogeneous Photoactivators for Visible-Light-Induced CuAAC Click Reactions

, 2015
In this work, a visible-light-induced copper­(I)-catalyzed azide–alkyne cycloaddition (CuAAC) click reaction via an electron transfer reaction employing fullerene (C60) containing linear polystyrene and network polymer as homogeneous and heterogeneous ...
Omer S. Taskin (1432423), Yusuf Yagci (743419), Gorkem Yilmaz (1432426), Yilmaz, Gorkem, Yağcı, Yusuf, Taskin, Omer S., Yagci, Yusuf   +6 more
core   +1 more source

Biomimetic N‐cyano sulfoximine–thiazole ligation for antibody–drug conjugate assembly

Bulletin of the Korean Chemical Society, EarlyView.
Biomimetic N‐cyano sulfoximine–thiazole ligation is applied for the first time to antibody–drug conjugate assembly. Installation of a sulfoximine handle on trastuzumab followed by ligation with a cysteine‐functionalized payload affords model ADCs with tunable drug‐to‐antibody ratios of 2–8 under mild aqueous conditions.
Eunsil Kim, Ji Ho Song, Na Ryeong Kim, Ji Young Hyun, Ju Yeon Lee, Do Hyun Kang, Hwan Jung Lim, Seong Jun Park   +7 more
wiley   +1 more source

Regio- and diastereoselective synthesis of β-lactam-triazole hybrids via passerini/CuAAC sequence

, 2013
Passerini (P-3CR) and Passerini-Smiles reactions were investigated in azetidine-2,3-diones, affording the corresponding 3,3-disubstituted-β- lactams with complete diastereoselectivity in high yields.
Alcaide, Benito, Aragoncillo, Cristina, Callejo, Ricardo, Torres, M. R., Almendros, Pedro, Ruiz, M. Pilar   +5 more
core   +1 more source

Mitochondria‐endoplasmic reticulum organelle glue as maturation promoter for origination/dimensional dual‐cross cardiomyocytes

BMEMat, EarlyView.
Mitochondria‐endoplasmic reticulum contact sites (MERCS) are areas where the mitochondria and endoplasmic reticulum closely interact. In this study, we utilize synthetic organelle glues to artificially engineer MERCS for regulating cardiomyocyte development, through which the immature and chemo‐plasticity issues of undifferentiated cells are addressed.
Wei Tang, Hao Sun, Chenqi Duan, Jiajia Chang, Yuxing Wang, Ming Zhao, Huiyue Zhao, Shan Lu, Yang Yang, Da Huo   +9 more
wiley   +1 more source

Fluorogenic “click” reaction for labeling and detection of DNA in proliferating cells

BioTechniques, 2010
A thymidine analog, 5-ethynyl-2′-deoxyuridine (EdU), has been reported as a rapid labeling tool for direct measurement of cells in S-phase. The alkynyl group of EdU is a biologically inert group that undergoes an extremely selective reaction with azido ...
Kai Li, L. Andrew Lee, Xiaobing Lu, Qian Wang   +3 more
doaj   +1 more source