Results 81 to 90 of about 11,111 (220)

Synthesis of Phospholipid-Protein Conjugates as New Antigens for Autoimmune Antibodies

Molecules, 2015
Copper(I)-catalyzed azide-alkyne cycloaddition, or CuAAC click chemistry, is an efficient method for bioconjugation aiming at chemical and biological applications.
Arindam Maity, Claudia Macaubas, Elizabeth Mellins, Kira Astakhova   +3 more
doaj   +1 more source

Stepwise, Protecting Group Free Synthesis of [4]Rotaxanes

Molecules, 2017
Despite significant advances in the last three decades towards high yielding syntheses of rotaxanes, the preparation of systems constructed from more than two components remains a challenge.
James E. M. Lewis, Joby Winn, Stephen M. Goldup   +2 more
doaj   +1 more source

Synthesis and application of some novel functional polymers via controlled radical polymerization and click chemistry [PDF]

The objective of this thesis was to prepare thermoresponsive PEG-based homopolymers and copolymers by combination of cobalt-mediated catalytic chain-transfer polymerization (CCTP) and thiol-ene “click” chemistry and prepare well-defined glycopolymers ...
Li, Guang-Zhao
core  

Dinuclear thiazolylidene copper complex as highly active catalyst for azid–alkyne cycloadditions

Beilstein Journal of Organic Chemistry, 2016
A dinuclear N-heterocyclic carbene (NHC) copper complex efficiently catalyzes azide–alkyne cycloaddition (CuAAC) “click” reactions. The ancillary ligand comprises two 4,5-dimethyl-1,3-thiazol-2-ylidene units and an ethylene linker.
Anne L. Schöffler, Ata Makarem, Frank Rominger, Bernd F. Straub   +3 more
doaj   +1 more source

Fluorophore-Assisted Click Chemistry through Copper(I) Complexation

Biomolecules, 2020
The copper-catalyzed alkyne-azide cycloaddition (CuAAC) is one of the most powerful chemical strategies for selective fluorescent labeling of biomolecules in in vitro or biological systems. In order to accelerate the ligation process and ensure efficient
Victor Flon, Magalie Bénard, Damien Schapman, Ludovic Galas, Pierre-Yves Renard, Cyrille Sabot   +5 more
doaj   +1 more source

Synthesis of fluorinated polypropylene using CuAAC click chemistry

Journal of Applied Polymer Science, 2018
ABSTRACTSynthesis of fluorine containing polypropylene (PPF) from chlorinated polypropylene (PPCl) via Cu(I) catalyzed Huisgen type 1,3‐dipolar cycloaddition (CuAAC) and its water repellency properties are demonstrated. Initially, clickable azido‐functional polypropylene (PPN3) and alkyne‐functionalized fluorine compound (FAl) are independently ...
G. Acik, C. Elif Cansoy, M. A. Tasdelen
openaire   +2 more sources

Synthese und aktivitätsbasierte Proteinprofilierung identifizieren die Aldo‐Keto‐Reduktase 1C3 als Zielprotein der Myxoglucamide

Angewandte Chemie, EarlyView.
Myxoglucamid A – ein neuartiges, aus Myxobakterien isoliertes Glykolipopeptid – wurde erstmals totalsynthetisch hergestellt. Mittels aktivitätsbasierter Proteinprofilierung (ABPP) wurde die Aldo‐Keto‐Reduktase 1C3 (AKR1C3) als primäres Zielprotein in menschlichen Zellen identifiziert.
Thomas Siemon, Vivek K. Mishra, Mingming Zhao, Konrad Büssow, Alexander Popoff, Chengzhang Fu, Rolf Müller, Lothar Jänsch, Wulf Blankenfeldt, Mark Brönstrup   +9 more
wiley   +1 more source

Multiplexed CuAAC Suzuki–Miyaura Labeling for Tandem Activity-Based Chemoproteomic Profiling

, 2021
Mass-spectrometry-based chemoproteomics has enabled the rapid and proteome-wide discovery of functional and potentially 'druggable' hotspots in proteins.
Castellón, José O, Chan, Neil J, Boatner, Lisa M, Desai, Heta S, Cao, Jian, Burton, Nikolas R, Armenta, Ernest, Backus, Keriann M   +7 more
core   +1 more source

One-Pot Synthesis of Imidazo[1,2-a]pyridines via Groebke–Blackburn–Bienaymé Reaction and CuAAC Assisted by MW

Chemistry Proceedings
Bis-heterocyclic compounds containing imidazo[1,2-a]pyridines (IMPs) are privileged heterocyclic drug scaffolds due to their potential applications. The Groebke–Blackburn–Bienaymé reaction (GBBR) is a greener alternative to synthesizing IMPs.
Manuel A. Rentería-Gómez, David Calderón-Rangel, Fidel Rodríguez-López, Alejandro Corona-Díaz, Rocío Gámez-Montaño   +4 more
doaj   +1 more source

Polypropylene-based graft copolymers via CuAAC click chemistry

eXPRESS Polymer Letters, 2018
Graft copolymers from commercial chlorinated polypropylene (PP-Cl) possessing either poly(ethylene glycol) (PEG) or poly(ε-caprolactone) (PCL) grafts are synthesized by copper (I)-catalyzed azide-alkyne cycloaddition ‘click’ reaction (CuAAC).
G. Acik, E. Sey, M. A. Tasdelen
doaj   +1 more source