Drug-Loaded, Bivalent-Bottle-Brush Polymers by Graft-through ROMP [PDF]
, 2010 Graft through ring-opening metathesis polymerization (ROMP) using ruthenium N heterocyclic carbene catalysts has enabled the synthesis of bottle-brush polymers with unprecedented ease and control Here we report the first bivalent-brush polymers, these ...
Burts, Alan O. +6 more
core +1 more source
Dinuclear thiazolylidene copper complex as highly active catalyst for azid–alkyne cycloadditions
Beilstein Journal of Organic Chemistry, 2016 A dinuclear N-heterocyclic carbene (NHC) copper complex efficiently catalyzes azide–alkyne cycloaddition (CuAAC) “click” reactions. The ancillary ligand comprises two 4,5-dimethyl-1,3-thiazol-2-ylidene units and an ethylene linker.
Anne L. Schöffler +3 more
doaj +1 more source
Design and Evaluation of Heterobivalent PAR1–PAR2 Ligands as Antagonists of Calcium Mobilization [PDF]
, 2019 A novel class of bivalent ligands targeting putative protease-activated receptor (PAR) heteromers has been prepared based upon reported antagonists for the subtypes PAR1 and PAR2.
Arnold, Leggy A. +5 more
core +1 more source
Synthesis of 1,2,3-triazole functionalized hyperbranched poly(ethyleneimine) and its use as multifunctional anionic macroinitiator for diglycidyl ether of bisphenol A curing [PDF]
, 2016 Hyperbranched poly(ethyleneimine) (PEI) has been modified by the addition of propargyl acrylate following a Michael addition reaction. On this polymer (PEI-yne) a copper (I)-catalyzed azide alkyne cycloaddition (CuAAC) has been performed to obtain a ...
Acebo Gorostiza, Cristina +4 more
core +2 more sources
Reactive precursor particles as synthetic platform for the generation of functional nanoparticles, nanogels, and microgels [PDF]
, 2019 Precise control of the chemical functionality of polymer nanoparticles is a key requirement in tailoring their (dynamic) colloidal properties toward advanced applications.
Gruber, Alexandra +2 more
core +1 more source
Carbon Energy, EarlyView.This review provides a comprehensive and systematic overview of the multifunctional design strategies for solid polymer electrolytes (SPEs), a pivotal component for enabling high‐performance all‐solid‐state batteries (ASSBs). It begins with a detailed classification of SPE systems and elaborates on their respective molecular design principles. The work
Bin Man +11 more
wiley +1 more source
Chemistry – A European Journal, EarlyView.A series of structurally diverse exoglycals was synthesized using a modified Julia‐olefination approach from sugar‐derived precursors. These glycosidase transition‐state mimics were further diversified via CuAAC chemistry to yield triazole‐conjugated analogues.
Elisa Ospanow +2 more
wiley +1 more source
Ruthenium-catalyzed azide alkyne cycloaddition reaction: scope, mechanism and applications [PDF]
, 2016 The ruthenium-catalyzed azide alkyne cycloaddition (RuAAC) affords 1,5-disubstituted 1,2,3-triazoles in one step and complements the more established copper-catalyzed reaction providing the 1,4-isomer.
Akimova G. +23 more
core +2 more sources
Engineering Bisubstrates to Target m6Am RNA Methyltransferases: Synthesis and Computational Studies
Chemistry – A European Journal, EarlyView.Use of the convertible nucleoside approach to synthesize m6Am RNA methyltransferase bisubstrates. This methodology allows for the introduction of modifications on the SAM analog moiety and the RNA substrate part, including the introduction of a cap analog by click chemistry.
Yoann Colas +3 more
wiley +1 more source
BioTechniques, 2015 Copper-catalyzed azide-alkyne cycloaddition (CuAAC) “click” chemistry is widely used and has demonstrated particular utility for bio-orthogonal conjugation reactions.
Jeremy Kallick +3 more
doaj +1 more source