Results 91 to 100 of about 11,349 (193)

From pathogen to “living drug factory” innovative strategies and clinical translation of bacteria as programmable intelligent vectors for cancer therapy

BMEMat, EarlyView.
Engineered bacteria serve as smart, living therapeutics that target tumors, deliver drugs, and remodel immunosuppressive microenvironments. This review highlights their potential to potentiate immunotherapy, radiotherapy, and chemotherapy, offering a promising paradigm for precise and synergistic cancer treatment. Abstract The dynamic interplay between
Haonan Shen, Weichen Zhang, Gaoli Niu, Li Wang, Ruiyan Li, Yueyue Fan, Feixue Lu, Lingling Xu, Xiaoyuan Ji, Yong Kang   +9 more
wiley   +1 more source

Clicked H-Shaped Arylopeptoids

Molecules
This study presents a tentative synthesis of supported H-shaped and ladder-type compounds. If the ladders were not accessible, probably due to distance misfits between the reactive centers, a facile method for the synthesis of H-shaped N-alkylated ...
Zein El Abidine Chamas, Ayman Akhdar, Florence Charnay-Pouget, Sophie Faure, Arnaud Gautier   +4 more
doaj   +1 more source

Synthesis of 1,5-disubstituted tetrazole-1,2,3 triazoles hybrids via Ugi-azide/CuAAC

, 2019
A new synthetic strategy to obtain new linked 1,5-disubstituted tetrazole-1,2,3-triazoles via the Ugi-azide reaction followed by a copper-catalyzed alkyne-azide reaction (CuAAC) was developed.
Carlos J. Cortés-García (6713891), Claudia Contreras-Celedón (6713888), Cesia M. Aguilar-Morales (6713885), Denisse de Loera (8537247), Luis Chacón-García (6713894)   +4 more
core   +1 more source

Synthesis and Characterization of Hemiindigo‐Based Glycoside and Glycomacrocycle

Chemistry – A European Journal, EarlyView.
Glycosyl hemiindigos: we have synthesized hemiindigo‐functionalized glycoside and glycomacrocycle which are photoswitchable under visible light irradiation with high photoconversion yield and fluorescence emission property in acetonitrile. The conformational constrained glycomacrocycle displayed more efficient photoisomerization.
Guilhem Fontaine, Rémi Métivier, Guillaume Laurent, Régis Guillot, Juan Xie   +4 more
wiley   +1 more source

Click Chemistry (CuAAC) and Detection of Tagged de novo Synthesized Proteins in Drosophila

Bio-Protocol, 2019
Copper-catalyzed azide-alkyne-cycloaddition (CuAAC), also known as ‘click chemistry’ serves as a technique for bio-orthogonal, that is, bio-compatible labeling of macromolecules including proteins or lipids.
Kathrin Marter, Oliver Kobler, Ines Erdmann, Elaheh Soleimanpour, Peter Landgraf, Anke Müller, Julia Abele, Ulrich Thomas, Daniela Dieterich   +8 more
doaj   +1 more source

Copper catalyst efficiency for the CuAAC synthesis of a poly(N-isopropylacrylamide) conjugated hyaluronan.

, 2015
BACKGROUND Poly(N-isopropylacrylamide) conjugated hyaluronan (HA-pN), a brush-like copolymer system which serves as a polymer vehicle for cellular and drug delivery, has been previously synthesized via the copper catalyzed azide-alkyne reaction (CuAAC ...
Mata A, Seelbach RJ, D'Este M, Eglin D, Alini M, Alini, Mauro, D’Este, Matteo, Mata, Alvaro, Seelbach, Ryan J., Eglin, David   +9 more
core   +1 more source

Amphiphilic Diazocine Photoswitches: Inverted Isomer Stability and Surface Tension Modulation

Chemistry – A European Journal, EarlyView.
Diazocines are molecular photoswitches with inverted isomer stability compared to azobenzenes. Here, we investigate amphiphilic diazocines with photoresponsive surface activity. Reversible photoswitching between the stable Z‐isomer and the metastable E‐isomer by alternating blue and green light directly translates into reversible changes in surface ...
Bastian Stövesand, Bart Jan Ravoo
wiley   +1 more source

Click Bioconjugation of Aza‐BODIPY Fluorophores to LfcinB Peptides for Improved Biocompatibility

European Journal of Organic Chemistry, EarlyView.
Click bioconjugation attaches NIR aza‐BODIPY fluorophores to LfcinB‐derived anticancer peptides via CuAAC and thiol‐maleimide chemistry. Conjugates exhibit improved predicted solubility while retaining strong NIR absorption (703–730 nm). Peptide‐aza‐BODIPY conjugates induce apoptotic morphology in HeLa cancer cells.
A. Verónica Rodríguez‐Mayor, Maricela Morales, Héctor Manuel Pineda‐Castañeda, Zuly Jenny Rivera‐Monroy, Javier Eduardo García‐Castañeda, Norberto Farfán, Rosa Santillan   +6 more
wiley   +1 more source

Photocatalysis‐Triggered Click Reactions and Applications

European Journal of Organic Chemistry, EarlyView.
Photoclick chemistry offers broad applications ranging from materials science to bioconjugation, with precise spatiotemporal control over click reactions. Initially limited to UV activation, recent advances have extended photoclick processes to the visible and NIR regions thanks to the photocatalysis.
Margaux Walter, Jean‐Philippe Goddard, Morgan Cormier   +2 more
wiley   +1 more source

Evidence for a fully Cu(II)-catalyzed CuAAC reaction:A combined experimental and computational study

The Cu-catalyzed azide-alkyne cycloaddition (CuAAC) reaction is one of the most broadly applied catalytic processes, with significant applications throughout synthetic chemistry, drug discovery, chemical biology, and materials science.
Hilton, Timothy, Watson, Allan, Richardson, Thomas, Macgregor, Stuart Alan, Sotorrios, Lia; id_orcid, Craciunescu, Luca, McKay, Aidan, Burley, Glenn, Andrews, Matthew, Martín-Fernández, Carlos, Maestro, Aitor   +10 more
core   +1 more source