Results 91 to 100 of about 11,111 (220)

Ein portalpräorganisiertes Cucurbit[7]uril‐Ruthenium‐Konjugat ermöglicht motivselektive Proteindetektion

Angewandte Chemie, EarlyView.
Die gezielte Veränderung der Erkennungsumgebung am Portal von Cucurbit[7]uril (CB7) wandelt einen Wirt ohne intrinsisches optisches Signal in einen motivselektiven photolumineszenten Rezeptor um. Das am Portal vororganisierte CB7‐Rubpy‐Konjugat zeigt Änderungen der Zugänglichkeit aromatischer Motive unmittelbar an und ermöglicht dadurch die optische ...
Patrick Gruhs, Albert Kraft, Vahideh Mahram, Marco Neumaier, Papri Chakraborty, Emily Janz, Maria Vittoria Balli, Pierre Picchetti, Luca Prodi, Manfred Kappes, Frank Biedermann   +10 more
wiley   +1 more source

Heterogeneous catalysis for azide-alkyne bioconjugation in solution via spin column: Attachment of dyes and saccharides to peptides and DNA

BioTechniques, 2015
Copper-catalyzed azide-alkyne cycloaddition (CuAAC) “click” chemistry is widely used and has demonstrated particular utility for bio-orthogonal conjugation reactions.
Jeremy Kallick, Sarah Harris, Andrew K. Udit, Michael G. Hill   +3 more
doaj   +1 more source

Tuning the optical properties of BODIPY dye through Cu(I) catalyzed azide-alkyne cycloaddition (CuAAC) reaction

, 2012
Borondipyrromethenes (BODIPY) are a class of fluorescent dyes whose fluorescence quantum yields are generally high and independent of the solvent. In this paper, we report the synthesis of a new type of BODIPY compound that carries an azido group on the ...
Suthiwangcharoen, Nisaraporn, Sun, J (reprint author), Chinese Acad Sci, Chengdu Inst Biol, Nat Prod Ctr, Chengdu 610041, Peoples R China, Xie Fang, Sun Jian, Wang Chao, Wang Qian   +5 more
core  

Efficient One-Pot Synthesis of Triazole-Linked Morpholinone Scaffolds by CuAAC in the Presence of 18-Crown-6

SynOpen, 2018
A range of bis-heterocyclic derivatives based on novel morpholinone­ and triazole heterocycles was prepared from iodo-morpholinone­. The key step in our strategy is a one-pot procedure based upon copper-catalysed alkyne-azide cycloaddition (CuAAC) from ...
A. Mayooufi, M. Romdhani-Younes, J. Thibonnet   +2 more
doaj   +1 more source

Zirkuläre, Photogeschützte mRNA für Lichtinduzierte Aktivierung der Translation zu späten Zeitpunkten

Angewandte Chemie, EarlyView.
Eine klickbare, photogeschützte 5′‐Kappe (CyCliCap) zur Herstellung von zyklischer, Click‐Cap enthaltender mRNA (Cyclic Click Cap‐mRNA), die bis zur Bestrahlung beachtlich stabil und translational stumm ist, ermöglicht die Aktivierung der Translation in Zellen zu späten Zeitpunkten mittels Lichts. ZUSAMMENFASSUNG mRNA ist eine neue Impfstofftechnologie
Bayram Terzi, Greta Charlotte Dahm, Kristoffer Heintz, Martin Sumser, Yasuaki Kimura, Hiroshi Abe, Andrea Rentmeister   +6 more
wiley   +1 more source

Fluorogenic “click” reaction for labeling and detection of DNA in proliferating cells

BioTechniques, 2010
A thymidine analog, 5-ethynyl-2′-deoxyuridine (EdU), has been reported as a rapid labeling tool for direct measurement of cells in S-phase. The alkynyl group of EdU is a biologically inert group that undergoes an extremely selective reaction with azido ...
Kai Li, L. Andrew Lee, Xiaobing Lu, Qian Wang   +3 more
doaj   +1 more source

Star-shaped polyacrylates : highly functionalized architectures via CuAAc click conjugation

, 2009
Well-defined functional star-shaped polymer structures with up to 29 arms have been successfully synthesized by the combination of atom transfer radical polymerization (ATRP) and click chemistry.
Richard Hoogenboom, Du Prez, Filip, Hoogenboom, R., Du Prez, F.E., Lammens, M., Martin W. M. Fijten, Hoogenboom, Richard, Fijten, M.W.M., Fijten, Martin WM, Fournier, D.J.R., Filip Du Prez, Mieke Lammens, Fournier, David, David Fournier, Lammens, Mieke   +14 more
core   +1 more source

Clicked H-Shaped Arylopeptoids

Molecules
This study presents a tentative synthesis of supported H-shaped and ladder-type compounds. If the ladders were not accessible, probably due to distance misfits between the reactive centers, a facile method for the synthesis of H-shaped N-alkylated ...
Zein El Abidine Chamas, Ayman Akhdar, Florence Charnay-Pouget, Sophie Faure, Arnaud Gautier   +4 more
doaj   +1 more source

Click Chemistry (CuAAC) and Detection of Tagged de novo Synthesized Proteins in Drosophila

Bio-Protocol, 2019
Copper-catalyzed azide-alkyne-cycloaddition (CuAAC), also known as ‘click chemistry’ serves as a technique for bio-orthogonal, that is, bio-compatible labeling of macromolecules including proteins or lipids.
Kathrin Marter, Oliver Kobler, Ines Erdmann, Elaheh Soleimanpour, Peter Landgraf, Anke Müller, Julia Abele, Ulrich Thomas, Daniela Dieterich   +8 more
doaj   +1 more source

Activation of Metal Complexes With Ultrasound Waves for Targeted Anticancer Therapy

Angewandte Chemie International Edition, EarlyView.
Ultrasound enables non‐invasive activation of metal‐based therapeutics deep within tumors. Acoustic cavitation can drive sonodynamic reactive oxygen species generation or mechanochemical metal–ligand bond dissociation, enabling controlled release of bioactive payloads.
Félix Grosjean, Nicolás Montesdeoca, Gilles Berger, Johannes Karges   +3 more
wiley   +1 more source