Results 111 to 120 of about 15,378 (241)

Chemical proteomics approaches for identifying the cellular targets of natural products. [PDF]

, 2016
Covering: 2010 up to 2016. Deconvoluting the mode of action of natural products and drugs remains one of the biggest challenges in chemistry and biology today.
Abegg, Abo, Agard, Alexander, Bachovchin, Bantscheff, Bantscheff, Bateman, Battenberg, Boersema, Boger, Broncel, Broncel, Böttcher, Böttcher, Böttcher, Cassiano, Charron, Cravatt, Dubinsky, Dubinsky, Eirich, Eirich, Ekkebus, Evans, Evans, Fischer, Fonovic, Geiger, Gersch, Heal, Hentzer, Heydenreuter, Hulce, Ishihama, Ismail, Ismail, Iwamaru, Kalesh, Kocaoglu, Koch, Kreuzer, Krysiak, La Clair, Lajkiewicz, Lanning, Lehmann, Leonti, Li, Li, Li, List, M. H. Wright, Mackinnon, MacKinnon, Martinez Molina, Meissner, Mellacheruvu, Moellering, Nahnsen, Nessen, Nickel, Nishino, Nodwell, Nordin, Old, Orth, Park, Patricelli, Patterson, Pitscheider, Preston, Rask-Andersen, Ravindran, Romeo, Rostovtsev, Rudolf, S. A. Sieber, Savitski, Schneider, Shannon, Shi, Shibata, Sibbersen, Smith, Speers, Speers, Srinivas, Staub, Staub, Stolze, Suchanek, Teplitski, Tietze, Tornoe, Trzoss, Vila, Wang, Wang, Wang, Wang, Wang, Wang, Weerapana, Weerapana, Weerapana, Weichert, White, White, Wirth, Wirth, Wittelsberger, Wright, Wright, Yang, Yang, Yang, Yang, Yang, Yu, Yu, Zeiler, Zhao, Zheng, Zhou, Ziegler   +125 more
core   +1 more source

Tetrazine Ligation in Living Systems: Beyond Fast Kinetics to Effective Bioorthogonality

Chemistry – A European Journal, EarlyView.
Rapid reaction kinetics (k2) alone do not ensure successful tetrazine ligation in living systems. This review introduces ‘effective orthogonality’—focusing on chemical survival, availability, and encounter—as a practical framework. We highlight how bottlenecks shift from cellular sinks to in vivo delivery limits, offering design strategies for reliable
Junhyeong Yim, Junyoung Park, Youngjun Lee, Jongmin Park   +3 more
wiley   +1 more source

Clicked H-Shaped Arylopeptoids

Molecules
This study presents a tentative synthesis of supported H-shaped and ladder-type compounds. If the ladders were not accessible, probably due to distance misfits between the reactive centers, a facile method for the synthesis of H-shaped N-alkylated ...
Zein El Abidine Chamas, Ayman Akhdar, Florence Charnay-Pouget, Sophie Faure, Arnaud Gautier   +4 more
doaj   +1 more source

Dual modification of biomolecules [PDF]

, 2016
With the advent of novel bioorthogonal reactions and “click” chemistry, an increasing number of strategies for the single labelling of proteins and oligonucleotides have emerged.
Chudasama, V, Maruani, A, Richards, DA
core   +1 more source

Antibacterial film from chlorinated polypropylene via CuAAC click chemistry

Progress in Organic Coatings, 2018
Abstract Polypropylene possessing quaternary ammonium salt (PP-QAS) is synthesized by copper (I)-catalyzed azide- alkyne cycloaddition “click” reaction (CuAAC) starting from chlorinated polypropylene (PP-Cl). The antibacterial properties of PP-QAS have been investigated on gram-positive (Staphylococcus aureus) and gram-negative (Escherichia coli ...
Gokhan Acik, Cagatay Altinkok, Hulya Olmez, Mehmet Atilla Tasdelen   +3 more
openaire   +5 more sources

A Low‐Symmetry FeII Tetrahedron From a Flexible Tritopic Ligand

Chemistry – A European Journal, EarlyView.
A highly symmetric and flexible tris‐bidentate tritopic ligand forms an S4 meso homoleptic face‐capped FeII tetrahedron near‐quantitatively in acetonitrile. The addition of nitromethane solvent causes partial isomerization of this meso cage to the racemic homochiral tetrahedron, with the complexity of the system being moderated through solvophobic ...
Rosemary J. Goodwin, Nina R. Lawson, Michael G. Gardiner, Jack D. Evans, Paul E. Kruger, Dan Preston   +5 more
wiley   +1 more source

Approaches to Asymmetric Click Chemistry [PDF]

, 2013
CuAAC 'click' is an invaluable synthetic tool, with asymmetric examples are beginning to emerge. However no rugged asymmetric CuAAC system has to date been discovered.
Martin, James
core  

Discovery of a Potent α ‑ Galactosidase Inhibitor by in Situ Analysis of a Library of Pyrrolizidine − (Thio)urea Hybrid Molecules Generated via Click Chemistry [PDF]

, 2018
The parallel synthesis of a 26-membered-library of aromatic/aliphatic-(thio)urea-linked pyrrolizidines followed by in situ biological evaluation toward α -galactosidases has been carried out.
Carmona Asenjo, Ana Teresa, Elías Rodríguez, María del Pilar, Ide, Daisuke, Kato, Atsushi, Miyawaki, Shota, Moreno Vargas, Antonio José, Pingitore, Valeria, Robina Ramírez, Inmaculada, Álvarez González, Eleuterio   +8 more
core   +1 more source

Polymeric Micellar Nanocatalysts for CuAAC Click Reaction in Water

Langmuir
Polymer-supported copper catalysts have attained a prominent status and continue to be a focal point of ongoing research and development due to their adaptable properties, which make them invaluable tools for diverse catalytic reactions in aqueous solutions.
Witsanu Sombat, Panuwat Padungros, Voravee P. Hoven   +2 more
openaire   +2 more sources

A personal 360° view of applications of ‘biomimetic’ molecular recognition

Journal of Chemical Technology &Biotechnology, EarlyView.
Abstract Molecular recognition between biological molecules has formed the basis for innumerable applications in biotechnology for the last seven decades or so. Techniques such as affinity chromatography, solid‐phase and aqueous two‐phase extraction, affinity precipitation, biomimetic catalytic systems, biosensors and molecular imprinting all exploit ...
Christopher R Lowe
wiley   +1 more source