Results 111 to 120 of about 11,111 (220)
BMEMat, EarlyView.Engineered bacteria serve as smart, living therapeutics that target tumors, deliver drugs, and remodel immunosuppressive microenvironments. This review highlights their potential to potentiate immunotherapy, radiotherapy, and chemotherapy, offering a promising paradigm for precise and synergistic cancer treatment. Abstract The dynamic interplay between
Haonan Shen +9 more
wiley +1 more source
Virus‐Mediated Self‐Assembly of Functional Cyclodextrins for Antiviral Inhibition
Angewandte Chemie, Volume 138, Issue 38, 14 September 2026.A sialic acid (SA)‐functionalized cyclodextrin (CD) self‐assembles on SARS‐CoV‐2 through ligand–receptor recognition, nucleating cooperative supramolecular polymer growth that blocks infection. The adaptive assembly requires both ligand binding and host–guest polymerization, remains active across variants, and can be tuned by coassembly, establishing ...
Pedro J. Hernando +10 more
wiley +2 more sources
Chemistry – A European Journal, EarlyView.Integrin αVβ3‐targeting small‐molecule drug conjugates (SMDCs) were synthesized by conjugating a cryptophycin payload through a neutrophil elastase‐cleavable NPV‐PABC linker. RGD peptidomimetic and linker epimers served as controls for targeting and enzymatic cleavage, and the resulting conjugates displayed subnanomolar cytotoxicity in vitro.
Dominic Seißenschmidt +3 more
wiley +1 more source
ReactionsDespite multiple advances in treatment and prevention, cancer remains one of the leading causes of death worldwide. Chemotherapy remains the most effective method for cancer treatment.
Delia Hernández-Romero +7 more
doaj +1 more source
Peptide Marriages: Modular Assembly of Multi‐Agonist Therapeutics
Chemistry – A European Journal, EarlyView.A modular polyethylene glycol (PEG) scaffold enables rapid assembly of dual peptide agonists using strain‐promoted azide–alkyne cycloaddition (SPAAC) and copper‐catalysed azide–alkyne cycloaddition (CuAAC). Glucagon‐like peptide‐1 (GLP‐1) and amylin agonists were combined with controlled valency, yielding low‐picomolar activity and receptor‐selective ...
Kristina A. Kostadinova +11 more
wiley +1 more source
Mild C─F Activation of Azido(per)Fluoroalkanes
Chemistry – A European Journal, EarlyView.Mild and selective activation of C(sp3)–F bonds in azido(per)fluoroalkanes using thiolates was developed, leading to novel functionalized azides. The reaction is initiated by nucleophilic attack of the sulfur atom to the terminal nitrogen of the azido group, followed by fluoride ion elimination.
Olena Shaitanova +7 more
wiley +1 more source
Metal‐Ion Regulated Light‐Free Z→E Isomerization of Azobenzene Glycomacrocycle
Chemistry – A European Journal, EarlyView.Metal ion‐catalyzed Z→E isomerization of photoswitchable azobenzene glycomacrocycle: A new azobenzene‐based glycomacrocycle is capable of forming a 1:1 complex with divalent metal ions in both E‐ and Z‐isomers. The complexes undergo light‐free Z→E isomerization in a timescale spanning from seconds to weeks.
Yang Zhou +4 more
wiley +1 more source
Novel ion-binding C3 symmetric tripodal triazoles: synthesis and characterization
Open Chemistry, 2014 Neumajer Gábor +3 more
doaj +1 more source
Tribochemical Surface Modification of Silicon
Chemistry – A European Journal, EarlyView.Mechanical scribing activates silicon surfaces by generating reactive sites that spontaneously graft alcohol‐, thiol‐, and alkyne‐terminated molecules under ambient conditions. Within 10 s, high‐coverage, electroactive organic layers form without light, heat, or applied voltage, offering a rapid tribochemical route to functional silicon interfaces for ...
Abdulrahman O. Abdulrahman +6 more
wiley +1 more source
Evidence for a fully Cu(II)-catalyzed CuAAC reaction:A combined experimental and computational study
The Cu-catalyzed azide-alkyne cycloaddition (CuAAC) reaction is one of the most broadly applied catalytic processes, with significant applications throughout synthetic chemistry, drug discovery, chemical biology, and materials science.
Hilton, Timothy +10 more
core +1 more source