Results 121 to 130 of about 15,690 (247)

Tetrazine Ligation in Living Systems: Beyond Fast Kinetics to Effective Bioorthogonality

Chemistry – A European Journal, EarlyView.
Rapid reaction kinetics (k2) alone do not ensure successful tetrazine ligation in living systems. This review introduces ‘effective orthogonality’—focusing on chemical survival, availability, and encounter—as a practical framework. We highlight how bottlenecks shift from cellular sinks to in vivo delivery limits, offering design strategies for reliable
Junhyeong Yim, Junyoung Park, Youngjun Lee, Jongmin Park   +3 more
wiley   +1 more source

Approaches to Asymmetric Click Chemistry [PDF]

, 2013
CuAAC 'click' is an invaluable synthetic tool, with asymmetric examples are beginning to emerge. However no rugged asymmetric CuAAC system has to date been discovered.
Martin, James
core  

Synthesis of Porphyrin and Bacteriochlorin Glycoconjugates through CuAAC Reaction Tuning

European Journal of Organic Chemistry, 2019
Rapid and reproducible access to a series of unique porphyrin and bacteriochlorin glycoconjugates, including meso‐glycosylated porphyrins and bacteriochlorins, and beta‐glycosylated porphyrins, using copper‐catalyzed azide–alkyne 1,3‐dipolar cycloaddition (CuAAC) is reported for the first time.
Matthew C. Bennion, Morgan A. Burch, David G. Dennis, Melissa E. Lech, Kira Neuhaus, Nikole L. Fendler, Matthew R. Parris, Jessica E. Cuadra, Charlie F. Dixon, George T. Mukosera, David N. Blauch, Laura Hartmann, Nicole L. Snyder, Joshua V. Ruppel   +13 more
openaire   +3 more sources

A Low‐Symmetry FeII Tetrahedron From a Flexible Tritopic Ligand

Chemistry – A European Journal, EarlyView.
A highly symmetric and flexible tris‐bidentate tritopic ligand forms an S4 meso homoleptic face‐capped FeII tetrahedron near‐quantitatively in acetonitrile. The addition of nitromethane solvent causes partial isomerization of this meso cage to the racemic homochiral tetrahedron, with the complexity of the system being moderated through solvophobic ...
Rosemary J. Goodwin, Nina R. Lawson, Michael G. Gardiner, Jack D. Evans, Paul E. Kruger, Dan Preston   +5 more
wiley   +1 more source

Safirinium Fluorescent “Click” Molecular Probes: Synthesis, CuAAC Reactions, and Microscopic Imaging

Molecules
Fluorescent labeling utilizing Cu(I)-catalyzed azide–alkyne cycloaddition reactions (CuAAC) is among the leading applications of the “click” chemistry strategy.
Patryk Kasza, Przemysław W. Szafrański, Joanna Fedorowicz, Faustyna Krzysztofiak, Krzysztof Pociecha, Katarzyna Wójcik-Pszczoła, Paulina Koczurkiewicz-Adamczyk, Mariusz Kępczynski, Jarosław Sączewski, Paweł Zajdel, Marek Cegła   +10 more
doaj   +1 more source

Synthesis and Reactivity of 3‐Aminosydnones in Cycloaddition Reactions With Alkynes

Chemistry – A European Journal, EarlyView.
The synthesis, functionalization, and reactivity as dipoles of 3‐aminosydnones have been investigated. These neglected compounds undergo smooth cycloaddition reactions with strained alkynes, leading to 1‐aminopyrazoles. ABSTRACT We present in this article the synthesis, functionalization, and properties of 3‐aminosydnones, a forgotten class of ...
Apolline Dominic, Timothée D'anfray, Guillaume Force, David‐Alexandre Buisson, Maxime Tricoire, Alexis Leblais, Davide Audisio, Frédéric Taran   +7 more
wiley   +1 more source

Quarternization of 3-azido-1-propyne oligomers obtained by copper(I)-catalyzed azide–alkyne cycloaddition polymerization

Beilstein Journal of Organic Chemistry, 2015
3-Azido-1-propyne oligomer (oligoAP) samples, prepared by copper(I)-catalyzed azide–alkyne cycloaddition (CuAAC) polymerization, were quarternized quantitatively with methyl iodide in sulfolane at 60 °C to obtain soluble oligomers.
Shun Nakano, Akihito Hashidzume, Takahiro Sato   +2 more
doaj   +1 more source

Precision Chemistry for Protein Lysine Modification

Chemistry – A European Journal, EarlyView.
Selective modification of lysine residues is challenging due to their similar intrinsic reactivity. Inspired by enzymatic recognition, ligand‐guided electrophiles enable site‐selective labeling and functionalization, while ligand‐guided catalyses achieve regioselective installation of bio‐relevant post‐translational modifications.
Mayu Onoda, Motomu Kanai
wiley   +1 more source

Traceable Traceless Delivery Tags

Helvetica Chimica Acta, EarlyView.
ABSTRACT This study elaborates on traceless tags for the thiol‐mediated uptake (TMU) of amine‐containing substrates of interest (SOIs). Traceless tags typically contain linkers that can be enzymatically cleaved to trigger the release of SOIs in their native form.
Julia Moreno, Xudong Ren, Saidbakhrom Saidjalolov, Pierre Josso, Naomi Sakai, Stefan Matile   +5 more
wiley   +1 more source

FRET‐Based Investigation of the Dynamics of Peptide‐Folded Single Chain Nanoparticles Inside Cancer Cells

Macromolecular Rapid Communications, EarlyView.
Little is known about the cellular uptake of single chain nanoparticles that are cross‐linked with dynamic bonds. Using Förster resonance energy transfer and fluorescence lifetime imaging microscopy (FRET‐FLIM) the dynamic nature of the bonds is seen, in which the interaction between two peptides, disassemble quickly, relatively.
Shegufta Farazi, Radhika Raveendran, Alexander MacMillan, Jarrod T. Hillyer, Robert Chapman, Martina H. Stenzel   +5 more
wiley   +1 more source