Results 131 to 140 of about 11,111 (220)

Bioorthogonal Reactions: Synthesis and Evaluation of Different Ligands in Copper Catalyzed Azide-Alkyne1,3-Dipolar Cycloaddition (CuAAC) [PDF]

, 2016
The Copper CatalyzedAzide-Alkyne1,3-Dipolar Cycloaddition (CuAAC) reaction has unique features that qualify it to be one of the best click reactions. Its applications have been shown in different aspects and for multiple purposes.
Almansaf, Zainab Abdullah
core  

Iron(II) and Copper(II) Ions Modulating Binding Interaction of Sugar‐Based Silatrane With DNA: Analytical and Theoretical Validation

Chemistry &Biodiversity, Volume 23, Issue 9, September 2026.
A new D‐glucamine‐based triazolyl silatrane and its Fe(II)/Cu(II) complexes exhibit metal‐induced modulation of CT‐DNA binding. Experimental and theoretical investigations reveal enhanced binding affinity and conversion from groove binding to a mixed groove‐binding/intercalative interaction. ABSTRACT Research on molecular systems capable of interacting
Gurjaspreet Singh, Pawan, Brij Mohan
wiley   +1 more source

Direct Mechanocatalysis and the Pursuit of Green Drug Synthesis

ChemCatChem, Volume 18, Issue 17, 14 September 2026.
We place the strategy of direct mechanocatalysis, in which the milling media itself serves as the catalyst, in the context of pharmaceutical synthesis, critically assessing the current state of the art, existing limitations, and future directions for development in the field.
Maximilian Wohlgemuth, Lars Borchardt, Johanna Templ   +2 more
wiley   +1 more source

Azide‐PEG‐Folate Functionalized Gadolinium Nanoparticles: A Preliminary Click‐Chemistry Platform for Magnetic Resonance Imaging Contrast

ChemistryOpen, Volume 15, Issue 9, September 2026.
The click‐modified targeted gadolinium nanoparticles are presented as a development of a multifunctional MRI contrast agent. The nanoplatform demonstrates improved stability and selective cellular targeting, and is expected to facilitate more precise tumor imaging while enabling further bioorthogonal conjugation for advanced cancer diagnosis and ...
Retna Putri Fauzia, Azmi Aulia Rahmani, Zahra Afriani, Theresia Cicilia Magdalena, Cindy Florencia Sutanto, Galuh Yuliani, Angga Cipta Narsa, Safri Ishmayana, Ratna Dini Haryuni, Huanhuan Liu, Santhy Wyantuti   +10 more
wiley   +1 more source

Aminopropyl-silica supported Cu nanoparticles: an efficient catalyst for continuous-flow Huisgen azide-alkyne cycloaddtion (CuAAC)

, 2014
Cu(I) catalyzed, Huisgen azide/alkyne 1,3-dipolar cycloaddition (CuAAC) is recognized as the tool of choice for ligating organic molecules in a numerous fields.
Psaro, Rinaldo, Evangelisti, Claudio, Jumde, Ravindra P., MANDOLI, ALESSANDRO   +3 more
core  

Design and Synthesis of Novel 1,2,3‐Triazole Conjugates Featuring Hydroxamic Acid and Sulfonamide Moieties: Exploring Dual Pharmacophores for Enhanced Biological Activity

Chemical Biology &Drug Design, Volume 108, Issue 3, September 2026.
Design and synthesis of novel 1,2,3‐triazole conjugates featuring hydroxamic acid and sulfonamide moieties: exploring dual pharmacophores for enhanced biological activity. ABSTRACT A new series of N‐hydroxy‐1‐(4‐(aryl sulfonamido)phenyl)‐1H‐1,2,3‐triazole‐4‐carboxamide derivatives (8a‐j) were synthesized through a concise multistep route integrating ...
Dineshkumar Pagar, Ranjay Shaw, Hemant Suryavanshi, Dhanji Rajani, Sudhakar Patil   +4 more
wiley   +1 more source

Not Quite Folded: Challenges in Predicting the hNPS‐hNPSR‐Ile107 Complex With AlphaFold2 Multimer

ChemMedChem, Volume 21, Issue 16, 27 August 2026.
AlphaFold2 Multimer guided the design of 20 novel human neuropeptide S (hNPS) cyclic analogues. Modelling bias toward the inactive state favoured receptor blockade over activation. Exploiting a stereochemical switch in the peptide hinge region yielded four potent NPS receptor (NPSR) antagonists with pA2 up to 6.20. Lines indicate conformational bridges
Valentina Albanese, Michela Argentieri, Federica Agosta, Alessandra Rizzo, Delia Preti, Rainer K. Reinscheid, Girolamo Calò, Remo Guerrini, Alfonso Carotenuto, Salvatore Pacifico, Chiara Ruzza, Antonella Ciancetta   +11 more
wiley   +1 more source

4-Sulfanyl-1,2,3-triazole as a Powerful Ligand in CuAAC to Synthesize 1,4-Substituted 1,2,3-Triazoles Under Solvent-Free and Low Catalyst Loading. [PDF]

Molecules
Shen J, Li J, Xu S, Wang T, Zou Z, Li H, Peng L, Tang Z, Xu X.   +8 more
europepmc   +1 more source

Orthogonal Triple-Click Synthesis of Heteromimetic Triglycosylated Fullerenes. [PDF]

Org Lett
Nieto-Ortiz G, Patino-Alonso J, Honrubia-Rodríguez N, Martín N, Herranz MÁ, Illescas BM.   +5 more
europepmc   +1 more source

Oligonucleotides Post-Synthetic Modifications: An Overview of Clickable Nucleoside Phosphoramidites Suitable for Solid-Phase Synthesis. [PDF]

Chembiochem
Depienne S, Bristiel A, Urban D, Guianvarc'h D.   +3 more
europepmc   +1 more source