Results 131 to 140 of about 11,349 (193)

Photo‐Degradable Polyester Networks and Multi‐Photon Printed Objects Based on Cyclic Ketene Acetals

Advanced Functional Materials, Volume 36, Issue 84, 19 October 2026.
The current work introduces a photoreversible polyester network derived from radical ring‐opening polymerization of cyclic ketene acetals. It combines photoreversible cross‐linking with initiator‐free multi‐photon printing. Reversible network formation, tunable mechanical properties, and selective degradation highlight its potential as a versatile ...
Till Meissner, Julian Fanelli, Vinh Xuan Truong, Rob Jones, Jens Gaitzsch, Christopher Barner‐Kowollik   +5 more
wiley   +1 more source

Supramolecular Degraders: An Emerging Paradigm in Targeted Protein Degradation

Advanced Science, Volume 13, Issue 58, 19 October 2026.
Dynamic supramolecular assembly reshapes targeted protein degradation by coordinating modular degrader construction, delivery, functional integration, and intracellular assembly or activation across proteasomal, endosomal–lysosomal, and autophagy–lysosomal pathways.
Kongjun Liu, Xue Yuan, Yan Zhou, Rui Yuan, Shaocheng Xie, Yong Chen, Peiyi Wang, Jianmei Gao, Qihai Gong   +8 more
wiley   +1 more source

The evolution of click chemistry: from classical reactions to next-generation platforms. [PDF]

RSC Adv
Dadfar SMM, Dadfar SM.
europepmc   +1 more source

Design and Synthesis of Novel Biginelli Adducts: Anticancer Activity and In Silico Study

Chemistry &Biodiversity, Volume 23, Issue 10, October 2026.
Compound 8n emerged as the most potent agent against MCF‐7 cells, inducing apoptosis and cell cycle arrest. Molecular docking identified Eg5 kinesin as a potential target, highlighting these derivatives as promising leads for cancer therapeutics.
Aida Iraji, Sara Moghadam Farid, Mohammadreza Eftekharian, Paniz Naseri, Mohammad Mahdavi, Mina Saeedi, Tahmineh Akbarzadeh   +6 more
wiley   +1 more source

Imidazo[1,2‐b]Pyrazole‐1,2,4‐oxadiazole Linked 1,2,3‐Triazoles: Synthesis, Antibacterial, Biofilm, and In Silico Studies

Chemistry &Biodiversity, Volume 23, Issue 10, October 2026.
A collection of innovative imidazo[1,2‐b]pyrazole–1,2,4‐oxadiazole–1,2,3‐triazole hybrids was conceived via the molecular hybridization of bioactive pharmacophores and produced via a CuAAC methodology. The synthesized compounds exhibited strong antibacterial and antibiofilm properties against gram‐positive bacteria.
Suresh Kumar Murahari, Kavitha Siddoju
wiley   +1 more source

Some Synthetic Approaches for Copper-Containing Terpyridine-Functionalized Polysiloxane Complexes. [PDF]

Polymers (Basel)
Kryukova SS, Votchel ER, Baykov SV, Boyarskiy VP, Islamova RM.   +4 more
europepmc   +1 more source

Synthesis of 1,2,3‐Triazole Derivatives of N,N‐Dimethyltryptamine Isolated From Mimosa tenuiflora Root Bark: Antiplasmodial Activity In Silico and In Vitro

Chemistry &Biodiversity, Volume 23, Issue 10, October 2026.
New 1,2,3‐disubstituted derivatives were synthesized from N,N‐dimethyltryptamine isolated from Mimosa tenuiflora and evaluated in vitro against chloroquine‐resistant P. falciparum W2. Compound 4 shows the best activity (IC50 = 4.8 ± µM) and selectivity index (> 10), while compound 7 shows the best binding energy (−9.8 kcal/mol) against PfPK7.
Renato Pinto de Sousa, William Cezar de Lima Silva, Caíque Lopes Duarte, Ana Claudia de Souza Pinto, Amanda Luisa da Fonseca, Fernanda Alice de Oliveira, Fernando de Pilla Varotti, Bruno Antônio Marinho Sanchez, Mahendra Rai, Maurício Pires de Moura do Amaral, Mariana Helena Chaves, João Sammy Nery de Souza, Warley de Souza Borges, Gerardo Magela Vieira Júnior   +13 more
wiley   +1 more source

Copper on Calcium Carbonate and Marble Waste as Recyclable Catalysts for Ultrasound-Assisted One-Pot Synthesis of 1,4-Disubstituted 1,2,3-Triazoles. [PDF]

ChemSusChem
Serra R, Fartade DJ, Caboni P, Carucci C, Salis A, Tuveri E, Rossi A, Citarella A, Porcheddu A.   +8 more
europepmc   +1 more source

Exploring Non‐Covalent Pin1‐PROTACs Insights Into Degradation Efficiency in Multiple Myeloma Cell Line

Chemistry &Biodiversity, Volume 23, Issue 10, October 2026.
Pin1, a PPIase linked to poor prognosis and drug resistance in Multiple Myeloma (MM), was targeted using 12 non‐covalent potential PROTACs based on “clickable” cell‐permeable ligands. Most compounds showed little or no activity, with P3 as the most effective. In contrast, the covalent PROTAC P1D‐34 induced potent Pin1 depletion, proving the feasibility
Lorenzo Meneghelli, Stephanie Davidson, Ji‐hyung Choi, Sami Mohammed Daddi Moussa, Simon Nadal, Delphine Ravault, Ludovic Carlier, Maud Larregola, Julien Pytkowicz, Chiara Zanato   +9 more
wiley   +1 more source

Extracellularly Activatable Conjugates of RGD Peptidomimetics and Cryptophycin for αVβ3‐Targeted Cancer Therapy

Chemistry – A European Journal, Volume 32, Issue 37, 1 October 2026.
Integrin αVβ3‐targeting small‐molecule drug conjugates (SMDCs) were synthesized by conjugating a cryptophycin payload through a neutrophil elastase‐cleavable NPV‐PABC linker. RGD peptidomimetic and linker epimers served as controls for targeting and enzymatic cleavage, and the resulting conjugates displayed subnanomolar cytotoxicity in vitro.
Dominic Seißenschmidt, Henriette Hartung, Jonah Kammer, Norbert Sewald   +3 more
wiley   +1 more source