Results 151 to 160 of about 15,690 (247)

Soft Ferroelectrics in One Dimension: Ferroelectric Columnar Liquid Crystals

ChemPlusChem, Volume 91, Issue 6, June 2026.
Helical ferroelectric columnar liquid crystals (FCLCs) confine bistable axial polarization within individual columns. An electric field reversibly flips the macrodipole, enabling two nonvolatile states readable as “0” and “1.” This Cconcept highlights supramolecular locking and helical architectures that deliver genuine switching and long‐lived zero ...
Seongwon Park, Byoung‐Ki Cho
wiley   +1 more source

The Application Prospects of Agarose as a Novel Skin Filler: A Narrative Review

Journal of Cosmetic Dermatology, Volume 25, Issue 6, June 2026.
ABSTRACT Background Agarose is a naturally derived polysaccharide that forms thermoreversible hydrogels with tunable rheological properties, making it a potential alternative platform to conventional dermal fillers. However, evidence regarding its physicochemical basis, preclinical performance, clinical outcomes, and the developmental status of ...
Jianwen Gao, Yulong Xie, Xin Zhang, Yandong Liu, Peipei Xia, Zehua Wang   +5 more
wiley   +1 more source

Synergistische Entwicklungsstrategien von Inhibitoren gegen humane UDP‐Galactose‐4‐Epimerase

Angewandte Chemie, Volume 138, Issue 22, 25 May 2026.
Die Epimerase GalE ist essenziell für die Biosynthese von krebsrelevanten O‐GalNAc Glykanen. Wir verwenden orthogonales, strukturbasiertes Screening niedermolekularer Fragmente an, um kovalente und nichtkovalente Inhibitoren gegen GalE mit nicht mehr als 22 optimierten Verbindungen zu erhalten.
William M. Browne, Jonathan Pettinger, Teresa Weckwerth, Andrew Purkiss, Sing Hei Lok, Louisa Penicaut, Roksana Ogrodowicz, Raveena Prema, Simone Kunzelmann, Chloe Roustan, Ganka Bineva‐Todd, Saskia Pieters, Francesca Zappacosta, Alfred E. Doherty, Isobel Oram, Christelle Soudy, Robert Quinlan, Joanna Redmond, Svend Kjaer, David House, Stephane Mouilleron, Jacob T. Bush, Benjamin Schumann   +22 more
wiley   +1 more source

A Synergistic Inhibitor Development Strategy Against Human UDP‐Galactose‐4‐Epimerase

Angewandte Chemie International Edition, Volume 65, Issue 22, 25 May 2026.
The epimerase GalE is crucial for the biosynthesis of cancer‐relevant O‐GalNAc glycans. Here, we employ orthogonal, structurally enabled small molecule fragment screens to yield both covalent and non‐covalent inhibitors against GalE within no more than 22 elaborated compounds.
William M. Browne, Jonathan Pettinger, Teresa Weckwerth, Andrew Purkiss, Sing Hei Lok, Louisa Penicaut, Roksana Ogrodowicz, Raveena Prema, Simone Kunzelmann, Chloe Roustan, Ganka Bineva‐Todd, Saskia Pieters, Francesca Zappacosta, Alfred E. Doherty, Isobel Oram, Christelle Soudy, Robert Quinlan, Joanna Redmond, Svend Kjaer, David House, Stephane Mouilleron, Jacob T. Bush, Benjamin Schumann   +22 more
wiley   +1 more source

4-Sulfanyl-1,2,3-triazole as a Powerful Ligand in CuAAC to Synthesize 1,4-Substituted 1,2,3-Triazoles Under Solvent-Free and Low Catalyst Loading. [PDF]

Molecules
Shen J, Li J, Xu S, Wang T, Zou Z, Li H, Peng L, Tang Z, Xu X.   +8 more
europepmc   +1 more source

Site-Specific Surface Modification via Chemoselective Click Reactions on Cyclobutene-Functionalized Monolayers. [PDF]

ChemistryOpen
Evans BW, Hipp KN, Lambert WD, Sittiwong W, Lai RY, Dussault PH.   +5 more
europepmc   +1 more source

Beyond Self-Assembly: Bioorthogonal 'Click' Chemistry Strategies for Robust Electrochemical Interfaces in Wearable Biosensors. [PDF]

Biosensors (Basel)
Merkezoğlu R, Yılmaz Ö, Kızılkurtlu AA.   +2 more
europepmc   +1 more source

Noncanonical amino acids enable plug and play vaccine platform in the ALiCE cell free system. [PDF]

NPJ Vaccines
Armero-Gimenez J, Schleusner J, Wilbers RHP, Schots A, Spiga L, Tregoning JS, Brown JC, Zhou J, Juergens H, Finnern R, Williams C.   +10 more
europepmc   +1 more source

The Copper-Catalyzed Azide-Alkyne Cycloaddition Reaction: Why Two Is Faster than One. [PDF]

Chemphyschem
Vermeeren P.
europepmc   +1 more source

One-Pot Enzymatic ADDing of Click Chemistry Handles for Protein Immobilization and Bioconjugation of Small and Biomolecules. [PDF]

Bioconjug Chem
Widodo WS, Fan X, Fürst MJLJ.
europepmc   +1 more source