Results 101 to 110 of about 6,459 (197)

Recent Advances in Conjugation Chemistry Expanding the Applications of the DNA Tetrahedron

Chemical Biology &Drug Design, Volume 108, Issue 2, August 2026.
The tetrahedral DNA nanostructure (TDN) is a promising drug delivery and biosensing platform that can be chemically modified with absolute payload precision. This review highlights explicit conjugation chemistries driving functionalization of the TDN for a broad range of applications, advancing its role in support of next‐generation biomimetic ...
Tyler J. Rutherford, Christopher J. Wilds   +1 more
wiley   +1 more source

Modulating the Swelling Behavior of Polymer Brushes via Interfacial Chemistry

Angewandte Chemie, Volume 138, Issue 29, 13 July 2026.
Modulating substrate surface chemistry of surface‐grafted polymer brushes via variation of the chemical composition of spacers that anchor initiators for surface‐initiated atom transfer polymerizations allows to tune swelling of these thin polymer films.
Kuljeet Kaur, Sabrina Sant, Leon A. Smook, Sissi de Beer, Harm‐Anton Klok   +4 more
wiley   +2 more sources

The Reality of Active Targeting in Nanomedicine: Promise Versus Performance

ChemBioChem, Volume 27, Issue 14, 29 July 2026.
Schematic representation of a multi‐functional nanocarrier decorated with diverse ligands. Ligand type, density and spatial organisation collectively determine targeting behaviour, highlighting the complexity of active targeting beyond simple ligand–receptor interactions.
Francesco Cellesi
wiley   +1 more source

Germanyl triazoles as a platform for CuAAC diversification and chemoselective orthogonal cross-coupling

Beilstein Journal of Organic Chemistry
We report the synthesis of germanyl triazoles formed via a copper-catalysed azide–alkyne cycloaddition (CuAAC) of germanyl alkynes. The reaction is often high yielding, functional group tolerant, and compatible with complex molecules. The installation of
John M. Halford-McGuff, Thomas M. Richardson, Aidan P. McKay, Frederik Peschke, Glenn A. Burley, Allan J. B. Watson   +5 more
doaj   +1 more source

Oligonucleotides Post‐Synthetic Modifications: An Overview of Clickable Nucleoside Phosphoramidites Suitable for Solid‐Phase Synthesis

ChemBioChem, Volume 27, Issue 13, 14 July 2026.
Clickable nucleoside phosphoramidites can be incorporated into oligonucleotides via solid‐phase synthesis (SPOS), enabling rapid and site‐specific post‐functionalization using bioorthogonal reactions. This review highlights their design, synthetic accessibility, and SPOS incorporation requirements, along with the kinetics and efficiency of post ...
Sébastien Depienne, Alexandra Bristiel, Dominique Urban, Dominique Guianvarc’h   +3 more
wiley   +1 more source

Light‐Activated Isolation of High‐Quality Mitochondria for Therapeutic Transplantation

Angewandte Chemie, Volume 138, Issue 28, 6 July 2026.
The Light‐Activated Mitochondrial Isolation (LAMI) platform enables the selective and non‐destructive isolation of high‐purity, metabolically active mitochondria. By integrating modular, ligand‐programmable magnetic probes with photo‐cleavable release, LAMI overcomes long‐standing limitations of conventional isolation methods and provides a robust ...
Hui Liu, Yuxin Jiao, Ting Zhang, Haiwei Wang, Yufei Xue, Jiayu Ding, Yang Ding, Meiling Wang, Weisen Zhang, Hua Bai, Bo Peng, Nicolas H. Voelcker, Lin Li   +12 more
wiley   +2 more sources

Kinetic and Spatial Resolution by dSTORM of miniSOG‐Mediated Proximity Labeling in Mammalian Cells

ChemBioChem, Volume 27, Issue 13, 14 July 2026.
Controlled blue‐light illumination defines the kinetic regimes and nanoscale labeling radius of miniSOG in mammalian cells. dSTORM imaging reveals an illumination‐tunable proximal labeling range (∼70–180 nm), establishing quantitative spatial parameters for miniSOG‐mediated photocatalytic tagging and enabling proximity‐labeling strategies.
Benoît Arnould, Alexandria L. Quillin, Aastha, Tatiana F. Flores, Jennifer M. Heemstra   +4 more
wiley   +1 more source

Probing 5‐Nitroimidazole‐Triazole Hybrids as Potential Anti‐Kinetoplastid Agents: Synthesis and In Vitro Efficacy

ChemMedChem, Volume 21, Issue 13, 14 July 2026.
A series of 5‐nitroimidazole‐1,2,3‐triazole hybrids was synthesised and evaluated for antitrypanosomatid activity to assess their potential as treatments against leishmaniasis and trypanosomiasis. No notable in vitro activity against Leishmania was detected.
Liandi Ferreira, Gideon D. Badenhorst, Janine Aucamp, Keisuke Suganuma, David D. N’Da   +4 more
wiley   +1 more source

Tetrazine Ligation in Living Systems: Beyond Fast Kinetics to Effective Bioorthogonality

Chemistry – A European Journal, Volume 32, Issue 26, 11 July 2026.
Rapid reaction kinetics (k2) alone do not ensure successful tetrazine ligation in living systems. This review introduces ‘effective orthogonality’—focusing on chemical survival, availability, and encounter—as a practical framework. We highlight how bottlenecks shift from cellular sinks to in vivo delivery limits, offering design strategies for reliable
Junhyeong Yim, Junyoung Park, Youngjun Lee, Jongmin Park   +3 more
wiley   +1 more source

4-Sulfanyl-1,2,3-triazole as a Powerful Ligand in CuAAC to Synthesize 1,4-Substituted 1,2,3-Triazoles Under Solvent-Free and Low Catalyst Loading. [PDF]

Molecules
Shen J, Li J, Xu S, Wang T, Zou Z, Li H, Peng L, Tang Z, Xu X.   +8 more
europepmc   +1 more source