Results 101 to 110 of about 11,111 (220)

Modulating catalytic activity of polymer-based cuAAC "click" reactions

, 2011
The copper(I)-catalyzed azide-alkyne cycloaddition (CuAAC) reaction is used to synthesize complex polymer architectures. In this work, we demonstrate the control of this reaction at 25 degrees C between polystyrene (PSTY) chains through modulating the ...
Jia, Zhongfan, Craig A. Bell, Michael J. Monteiro, Monteiro, Michael J., Bell, Craig A., Sébastien Perrier, Perrier, Sebastien, Zhongfan Jia   +7 more
core   +1 more source

Selective Chemical Modification of DNA with Boronic Acids by On-Column CuAAc Reactions

, 2020
International audienceThe use of the Cu(I)-catalyzed azide-alkyne cycloaddition (CuAAC) reaction for the preparation of oligonucleotide conjugates is by now familiar.
Debiais, Mégane, Smietana, Michael, Müller, Sabine, Vasseur, Jean-Jacques   +3 more
core   +1 more source

A Portal‐Preorganized Cucurbit[7]uril‐Ruthenium Conjugate Enables Motif‐Selective Protein Sensing

Angewandte Chemie International Edition, EarlyView.
Reprogramming cucurbit[7]uril (CB7) recognition through portal engineering transforms an optically silent host into a motif‐selective photoluminescent receptor. The portal‐preorganized CB7‐Rubpy conjugate directly reports changes in aromatic motif accessibility, enabling optical sensing of protein misfolding and refolding.
Patrick Gruhs, Albert Kraft, Vahideh Mahram, Marco Neumaier, Papri Chakraborty, Emily Janz, Maria Vittoria Balli, Pierre Picchetti, Luca Prodi, Manfred Kappes, Frank Biedermann   +10 more
wiley   +1 more source

Effects of a Flexible Alkyl Chain on a Ligand for CuAAC Reaction

, 2016
Imidazole derivatives substituted by a normal alkyl group are shown to be efficient as a ligand for the copper(Ι)-catalyzed azide−alkyne cycloaddition (CuAAC) reaction. An alkyl chain on the imidazole ligands shows an efficient steric effect and benefits
Seijiro Matsubara (1490731), Keisuke Asano (1592053)   +1 more
core   +1 more source

Safirinium Fluorescent “Click” Molecular Probes: Synthesis, CuAAC Reactions, and Microscopic Imaging

Molecules
Fluorescent labeling utilizing Cu(I)-catalyzed azide–alkyne cycloaddition reactions (CuAAC) is among the leading applications of the “click” chemistry strategy.
Patryk Kasza, Przemysław W. Szafrański, Joanna Fedorowicz, Faustyna Krzysztofiak, Krzysztof Pociecha, Katarzyna Wójcik-Pszczoła, Paulina Koczurkiewicz-Adamczyk, Mariusz Kępczynski, Jarosław Sączewski, Paweł Zajdel, Marek Cegła   +10 more
doaj   +1 more source

Photopolymerization of Cu(I)-catalyzed azide-alkyne cycloaddition (CuAAC) 'click'-based networks for new-age materials

, 2018
Kloxin, Christopher J.The copper(I)-catalyzed azide-alkyne cycloaddition (CuAAC) reaction is one of the most powerful tools in the ‘click’ chemistry toolbox and is immensely useful for an array of materials research avenues and applications.
Shete, Abhishek Umakant
core   +1 more source

Circular Photocaged mRNA for Light‐induced Late‐stage Activation of Translation

Angewandte Chemie International Edition, EarlyView.
A clickable photo‐caged 5′ cap (CyCliCap) allows to make Cyclic Click Cap‐containing mRNA (CyCliCap‐mRNA) which is remarkably stable and translationally muted until irradiated, allowing for late‐stage activation of translation in cells by light. ABSTRACT mRNA is a new medical modality as vaccine and raises hopes to become a protein replacement agent ...
Bayram Terzi, Greta Charlotte Dahm, Kristoffer Heintz, Martin Sumser, Yasuaki Kimura, Hiroshi Abe, Andrea Rentmeister   +6 more
wiley   +1 more source

Quarternization of 3-azido-1-propyne oligomers obtained by copper(I)-catalyzed azide–alkyne cycloaddition polymerization

Beilstein Journal of Organic Chemistry, 2015
3-Azido-1-propyne oligomer (oligoAP) samples, prepared by copper(I)-catalyzed azide–alkyne cycloaddition (CuAAC) polymerization, were quarternized quantitatively with methyl iodide in sulfolane at 60 °C to obtain soluble oligomers.
Shun Nakano, Akihito Hashidzume, Takahiro Sato   +2 more
doaj   +1 more source

Mitochondria‐endoplasmic reticulum organelle glue as maturation promoter for origination/dimensional dual‐cross cardiomyocytes

BMEMat, EarlyView.
Mitochondria‐endoplasmic reticulum contact sites (MERCS) are areas where the mitochondria and endoplasmic reticulum closely interact. In this study, we utilize synthetic organelle glues to artificially engineer MERCS for regulating cardiomyocyte development, through which the immature and chemo‐plasticity issues of undifferentiated cells are addressed.
Wei Tang, Hao Sun, Chenqi Duan, Jiajia Chang, Yuxing Wang, Ming Zhao, Huiyue Zhao, Shan Lu, Yang Yang, Da Huo   +9 more
wiley   +1 more source

Site-Specific Modification of Proteins through N‑Terminal Azide Labeling and a Chelation-Assisted CuAAC Reaction

, 2019
Site-specific modification of peptides and proteins is an important method for introducing an artificial function to the protein surface. Recently, we found that new bioconjugation reagents, 6-(azidomethyl)-2-pyridinecarbaldehyde (6AMPC) derivatives ...
Takashi Hayashi (298480), Akira Onoda (1470163), Nozomu Inoue (689171)   +2 more
core   +1 more source