Results 101 to 110 of about 11,349 (193)

Boronic Acid Inhibitors of β‐Lactamases: A Promising Strategy Against Antimicrobial Resistance

Medicinal Research Reviews, EarlyView.
ABSTRACT The rise of antimicrobial resistance (AMR) poses a critical threat to global health, mostly due to the proliferation of β‐lactamases, a class of enzymes responsible for the inactivation of β‐lactam antibiotics. Among the most promising strategies to restore β‐lactam efficacy is the use of β‐lactamase inhibitors (BLIs), with boronic acid ...
Nicolò Santi, Federico Corsini, Robert A. Bonomo, Emilia Caselli, Fabio Prati   +4 more
wiley   +1 more source

Extent of the Oxidative Side Reactions to Peptides and Proteins During the CuAAC Reaction

, 2016
The copper-catalyzed azide–alkyne cycloaddition (CuAAC) reaction is a powerful tool for bioconjugation of biomolecules, particularly proteins and peptides.
Honghao Cai (510333), Chengzhi Cai (1322091), Jilin He (3116919), Siheng Li (1322085), Zhiling Zhu (3116931), Srujana Lam (3116922), Steven J. Bark (3116925), Haoqing Chen (3116928), Tao Cai (19539)   +8 more
core   +1 more source

Self‐Assembled Monolayers on Gold Surfaces of Ferrocene‐BODIPY‐Fullerene‐Helical Peptide Conjugates: Studies of Electron Transfer Processes by Ultra‐Fast Electrochemistry

Journal of Peptide Science, Volume 32, Issue 12, December 2026.
Three ferrocene‐BODIPY‐C60‐peptides (T1–T3) were synthesized and grafted on gold surfaces to form self‐assembled monolayers. Calculation of the tilt angles and surface density of these SAMs using PM‐IRRAS and ultrafast electrochemical experiments revealed that less vertically oriented and densely packed monolayers were obtained compared with previously
Jad Rabah, Anne Vallée, Hélène Fensterbank, Minh‐Huong Ha‐Thi, Rachel Méallet, Souhir Boujday, Emmanuel Maisonhaute, Karen Wright, Emmanuel Allard   +8 more
wiley   +1 more source

A Role for Janus Cyclohexyl Ring Motifs in Medicinal Chemistry. Incorporation Into G‐Quadruplex Ligands and Anti‐Trypanosoma brucei Activity

ChemBioChem, Volume 27, Issue 21, 12 November 2026.
Naphthalene diimide (NDI) cores with peripheral fluorocyclohexyl ring systems are explored binding to G‐quadruplex DNA and were also assayed against the Trypanosoma brucei parasite. The most active compound of the series displayed nanomolar activity and suggested electrostatic interactions between the polarized cyclohexane and G‐Quad DNA.
Josephine M. Stewart, Mario Kehler, Vytautas Kuodis, Gary N. Parkinson, Wenqian Chen, Terry K. Smith, Zoë A. E. Waller, David O’Hagan   +7 more
wiley   +1 more source

Modulating catalytic activity of polymer-based cuAAC "click" reactions

, 2011
The copper(I)-catalyzed azide-alkyne cycloaddition (CuAAC) reaction is used to synthesize complex polymer architectures. In this work, we demonstrate the control of this reaction at 25 degrees C between polystyrene (PSTY) chains through modulating the ...
Jia, Zhongfan, Craig A. Bell, Michael J. Monteiro, Monteiro, Michael J., Bell, Craig A., Sébastien Perrier, Perrier, Sebastien, Zhongfan Jia   +7 more
core   +1 more source

Thiolane Sulfoximines as Azide Surrogates for Quinolyl Nitrenes: Photochemical Access to Ortho‐Diaminoquinolines

Advanced Synthesis &Catalysis, Volume 368, Issue 21, 3 November 2026.
Thiolane sulfoximines provide practical and safer surrogates for hazardous azides in nitrene photochemistry, enabling direct access to 7,8‐diaminoquinolines and fused δ‐lactams. DFT calculations support the reaction mechanism and rationalize product selectivity.
Lorenzo Serusi, Timothé Maujean, Camille Van Wesemael, Romain Pertschi, Vicenç Branchadell, Mihaela Gulea   +5 more
wiley   +1 more source

Safirinium Fluorescent “Click” Molecular Probes: Synthesis, CuAAC Reactions, and Microscopic Imaging

Molecules
Fluorescent labeling utilizing Cu(I)-catalyzed azide–alkyne cycloaddition reactions (CuAAC) is among the leading applications of the “click” chemistry strategy.
Patryk Kasza, Przemysław W. Szafrański, Joanna Fedorowicz, Faustyna Krzysztofiak, Krzysztof Pociecha, Katarzyna Wójcik-Pszczoła, Paulina Koczurkiewicz-Adamczyk, Mariusz Kępczynski, Jarosław Sączewski, Paweł Zajdel, Marek Cegła   +10 more
doaj   +1 more source

‐lactide) copolymers by CuAAC click chemistry

, 2018
Altinkok, Cagatay (Trakya author)The syntheses of polypropylene-graft-poly(l-lactide) copolymers (PP-g-PLAs) via copper (I)-catalyzed azide-alkyne cycloaddition "click" reaction (CuAAC) using azide side-chain functionalized polypropylene (PP-N-3) and ...
Mehmet Atilla Tasdelen, Cagatay Altinkok, Altinkok, Cagatay, Acik, Gokhan, Tasdelen, Mehmet Atilla, Gokhan Acik   +5 more
core   +1 more source

Strain and Chirality: Catalytic Asymmetric Synthesis of Planar Chiral [2.2]Paracyclophanes

ChemistryEurope, Volume 4, Issue 11, November 2026.
Catalytic asymmetric synthesis is transforming access to planar‐chiral [2.2]paracyclophanes. This Review highlights recent advances in catalytic desymmetrization and asymmetric functionalization, emphasizing how catalyst design and PCP geometry govern reactivity and stereocontrol.
Daniel Alonso, Enrique Gómez‐Bengoa, Rosa López   +2 more
wiley   +1 more source

Redox‐Active Verdazyl Radical Polymers via Postpolymerization Modification of Active Ester Polymers

ChemPlusChem, Volume 91, Issue 11, November 2026.
Organic radical polymers were synthesized via postpolymerization modification (PPM) of poly(pentafluorophenyl (meth)acrylate) with diverse 6‐oxoverdazyl stable radicals. This work servs as an electrochemical proof‐of‐concept, exhibiting a chemically reversible redox couple at 3.43 V versus Li/Li+, validating the electrochemical accessibility of the ...
Theo A. Ellingsen, James D. Randall, Bhagya Dharmasiri, Wesley J. Olivier, Luke C. Henderson, Melissa K. Stanfield, Stuart C. Thickett, Rebecca O. Fuller   +7 more
wiley   +1 more source