Results 261 to 270 of about 227,350 (349)

Harnessing Molecular Recognition for Small‐Molecule‐Mediated Reversible Photochemical Control Over mRNA Translation

open access: yesAngewandte Chemie, EarlyView.
A small molecule ligand undergoes traceless, reversible photocrosslinking to PreQ1 RNA aptamer in a selective manner, dependent on both the RNA sequence/structure and ligand chemical structure. A caged mRNA construct incorporating the PreQ1 aptamer and an eGFP or p53 coding sequence remained translationally repressed until exposure to 302 nm light ...
Shaifaly Parmar   +5 more
wiley   +1 more source

Size‐Programmable Matteson‐Type Annulation: Construction of Spirocycles from Simple Cyclic Ketones

open access: yesAngewandte Chemie, EarlyView.
An iterative boron‐homologation approach is developed to enable programmable syntheses of various carbocycles with different sizes stereoselectively from simple precursors. This method utilizes an electron‐withdrawing group (EWG) as a handle to enable intramolecular Matteson‐type couplings, leading to diastereoselective and enantioselective ring ...
Woohyun Jo   +4 more
wiley   +1 more source

Low‐Symmetry Face‐Capped Fe(II) Tetrahedra Through Anisotropic Ligand Extension

open access: yesAngewandte Chemie, EarlyView.
A strategy for the formation of low‐symmetry face‐capped Fe(II) tetrahedra using anisotropic ligand extension is reported. The degree of distortion in the resulting tetrahedra correlates to the stability of the assemblies and the oxidation potentials of their metal ions. Abstract Low‐symmetry cages are attractive metallo‐supramolecular targets, as they
Jacob A. Gome   +7 more
wiley   +1 more source

Unnatural Triggers Converted From Tetrazine‐Attached Sialic Acid for Activation of Optoacoustic Imaging‐Guided Cancer Theranostics

open access: yesAngewandte Chemie, EarlyView.
Tetrazine precursors (SiaTz) based on a nonO‐acetylated sialic acid scaffold are rationally designed and synthesized, which can be efficiently converted into unnatural tetrazine (Tz) triggers on cancer cell surfaces via metabolic glycoengineering. These Tz triggers activate theranostic agents for multispectral optoacoustic tomographic (MSOT) imaging ...
Yinglong Wu   +15 more
wiley   +1 more source

Reaction of barbituric acid with organic azides and phosphonium ylides

open access: yesOpen Chemistry, 2013
Lebedyeva Iryna   +5 more
doaj   +1 more source

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