Results 281 to 290 of about 227,350 (349)

Imaging Heterogeneous Patterns of Aminopeptidase N Activity in Hierarchical Tissue Structures Through High‐Resolution Whole‐Organ 3D Mapping

Angewandte Chemie, EarlyView.
Enzymes regulate physiological functions, and their abnormal activity is associated with diseases. Here, we present a method for high‐resolution 3D mapping of enzyme activity using tissue clearing and an activity‐based covalent probe. Focusing on aminopeptidase N, we developed ANA‐o‐BODIPY, which records enzyme activity via covalent labeling.
Bo Yi, Hiroyuki Yatabe, Daichi M. Sakamoto, Iori Tamura, Yutaro Saito, Naoki Yamada, Ruki Ashikaga, Masafumi Kuroda, Shimpei I. Kubota, Kazuki Tainaka, Shinsuke Sando   +10 more
wiley   +1 more source

Access to N‐Monofluoromethylated (Thio)Carbamates, Formamides, Alkynamides, and Related Derivatives

Angewandte Chemie, EarlyView.
The first general synthetic access to N‐CH₂F and N‐CHRF carbamates, thiocarbamates, formamides, alkynamides, and related compounds is disclosed. The method involves the direct synthesis of carbamoyl fluoride building blocks from readily available amines, followed by their derivatization. Abstract This work presents the first general synthetic access to
Filip G. Zivkovic, Fritz Bahns, Che‐Ming Hsu, Franziska Schoenebeck   +3 more
wiley   +1 more source

Cysteine-selective [¹⁸⁸Re]Re(v) radiolabelling of a Nanobody® for targeted radionuclide therapy using a "chelate-then-click" approach. [PDF]

Chem Sci
Melis DR, Segers C, Wellens J, Van de Voorde M, Blacque O, Ooms M, Gasser G, Opsomer T.   +7 more
europepmc   +1 more source

THE THERMAL DECOMPOSITION OF IRRADIATED $alpha$-LEAD AZIDE

, 1963
Joseph Jach
openalex   +2 more sources

Preparation of Thermally and Photochemically Immobilized N‐type Conjugated Polymer Films via Quantitative Backbone Editing

Angewandte Chemie, EarlyView.
A postpolymerization modification (PPM) of n‐type conjugated polymers by nucleophilic aromatic substitution is reported, enabling precise tuning of solubility, ordering, and stability. The method allows the facile introduction of azide groups, which can undergo UV‐ or thermally induced crosslinking, to afford stable, insoluble films with retained ...
Charlotte Rapley, Adam V. Marsh, Edgar Gutierrez‐Fernandez, Mohamad Insan Nugraha, Flurin Eisner, Martina Rimmele, Jaime Martín, Thomas D. Anthopoulos, Martin Heeney   +8 more
wiley   +1 more source

Using Triazabutadienes as a Protected Source of Diazonium Cations to Facilitate Electrografting to a Variety of Conductive Surfaces. [PDF]

Langmuir
Yates NDJ, Hudson L, Schwabe O, Parkin A.   +3 more
europepmc   +1 more source

Iodine-Azide Reaction and its Application to Quantitative Micro-Analysis. (XII). The Mechanism of Iodine-Azide Reaction. (Part 1).

, 1962
Shin Suzuki
openalex   +2 more sources

Fast and Autonomous Mannosylated Nanomotors for Dynamic Cancer Cell Targeting

Angewandte Chemie, EarlyView.
An enzyme‐loaded nanomotor decorated with mannose polymers shows a synergistic effect with respect to cell targeting. The mannose units interact with mannose receptors (MRs) on the cell surface, whereas the presence of the glycopolymer on the motor surface also leads to a more effective motile behavior in cell medium. Abstract An attractive strategy in
Yuechi Liu, Roberto Terracciano, Jari Scheerstra, Gokhan Yilmaz, Hanglong Wu, Pascal Welzen, Shoupeng Cao, Tania Patino Padial, Loai Abdelmohsen, Jingxin Shao, Bingbing Sun, C. Remzi Becer, Jan C. M. van Hest   +12 more
wiley   +1 more source

Isolation of a Staudinger-type Intermediate Utilizing a Five-Membered Phosphorus-Centered Biradicaloid. [PDF]

Chemistry
Pilopp Y, Bresien J, Lüdtke KP, Schulz A.   +3 more
europepmc   +1 more source

Structural Basis for the Catalytic Mechanism of ATP‐Dependent Diazotase CmaA6

Angewandte Chemie, EarlyView.
Several diazotases have been reported in recent years, but the detailed catalytic mechanism is unclear. From X‐ray crystallography and Cryo‐EM analysis, we obtained the structure of a diazotase CmaA6, which synthesizes 3‐diazocoumaric acid. Kinetic analysis and computational analysis indicated that CmaA6 catalyzes diazotization via an unprecedented ...
Seiji Kawai, Masayuki Karasawa, Yoshitaka Moriwaki, Tohru Terada, Yohei Katsuyama, Yasuo Ohnishi   +5 more
wiley   +1 more source