Results 161 to 170 of about 3,434 (226)

Advances in 2H-azirine chemistry: A seven-year update

Tetrahedron, 2019
2H-Azirines are versatile building blocks for the preparation of various nitrogen-containing heterocycles. Seven years ago the comprehensive review on azirine chemistry was published in Tetrahedron.
A. Khlebnikov, M. Novikov, N. Rostovskii
semanticscholar   +1 more source

Azirine-containing dipeptides and depsipeptides: synthesis, transformations and antibacterial activity.

Organic and biomolecular chemistry, 2020
Azirine-containing dipeptides and depsipeptides with a wide range of substituents have been synthesized in high yields via the Passerini and Ugi multicomponent reactions (MCRs) using 2H-azirine-2-carboxylic acids as the acid component.
N. Rostovskii, Alexander N. Koronatov, P. Sakharov, A. Agafonova, M. Novikov, A. Khlebnikov, E. Rogacheva, L. Kraeva   +7 more
semanticscholar   +1 more source

1-(2H-Azirine-2-carbonyl)benzotriazoles: building blocks for the synthesis of pyrrole-containing heterocycles.

Organic and biomolecular chemistry, 2020
A one-pot method was developed for the preparation of 2H-azirine-2-carbonylbenzotriazoles, formed by the reaction of benzotriazole with 2H-azirine-2-carbonyl chlorides, which were generated by the Fe(ii)-catalyzed isomerization of 5-chloroisoxazoles. The
E. Galenko, F. M. Shakirova, Vladimir A Bodunov, M. Novikov, A. Khlebnikov   +4 more
semanticscholar   +1 more source

Functionalized azirine based scaffolds as endothelin inhibitors for the selective anti-angiogenic activity.

European journal of medicinal chemistry
Anti-angiogenic therapy has long been used as an adjunct therapy for the resolution of tumor burden. The current findings describe the synthesis of novel marine-based azirine-containing compounds that exhibit anti-angiogenic mediated anti-tumor activity.
Himalaya Singh, Nagam Satish, T. Babu, Abhinav Singh, Babita Yadav, S. K. Singh, M. Wahajuddin, M. I. Siddiqui, Kumaravelu Jagavelu, G. Sudhakar   +9 more
semanticscholar   +1 more source

2H-Azirines in medicinal chemistry

Chemistry of Heterocyclic Compounds, 2021
The review presents an analysis of studies published in the period 1971–2020 devoted to examination of the biological activity of natural and synthetic 2H-azirine derivatives, their use for bioconjugation, as well as search for some new synthetic methods of structural modification of azirines with the aim of improving their biological activity.
Pavel А. Sakharov, Mikhail S. Novikov, Nikolai V. Rostovskii   +2 more
openaire   +1 more source

ChemInform Abstract: AZIRINE ALKYLATION

Chemischer Informationsdienst, 1976
AbstractDas Azirin (I) wird durch Trifluormethansulfonsäuremethylester zum Salz (III) gespalten, das mit Natriumhydrogencarbonat quantitativ die Base (IV) ergibt und mit verd. Salzsäure in Äthanol zum Pyraziniumsalz (V) cyclisiert.
J. A. DEYRUP, W. A. SZABO
openaire   +1 more source

Insights into N-Heterocyclic Carbene (NHC)-Catalyzed Asymmetric Addition of 2H-Azirine with Aldehyde.

Chemistry - An Asian Journal, 2019
The possible mechanisms and origin of the enantioselectivity of the reaction between 2H-azirine and an aldehyde catalyzed by an N-heterocyclic carbene (NHC) were theoretically studied and predicted at the M06-2X/6-31G(d,p)/IEF-PCMMTBE //M06-2X-GD3/6-311++
Qiuli Liu, Ling Sun, Shijun Li, Xue Li, L. Qu, Y. Lan, D. Wei   +6 more
semanticscholar   +1 more source

2-Diazoacetyl-2 H-azirines: Source of a Variety of 2 H-Azirine Building Blocks with Orthogonal and Domino Reactivity.

Journal of Organic Chemistry, 2018
A synthesis of 2-diazoacetyl-2 H-azirines was developed starting from 2 H-azirine-2-carbonyl chlorides, generated by Fe(II)-catalyzed isomerization of 5-chloroisoxazoles.
P. Sakharov, M. Novikov, A. Khlebnikov
semanticscholar   +1 more source

An Azirine Strategy for the Synthesis of Alkyl 4-Amino-5-(trifluoromethyl)-1H-pyrrole-2-carboxylates

Synthesis, 2018
1-(3,3,3-Trifluoro-2,2-dihydroxypropyl)pyridin-1-ium bromide serves as a trifluoromethyl-containing building block for the preparation of trifluoromethyl-substituted aminopyrroles based on the 2H-azirine ring expansion strategy.
A. Khlebnikov, L. Funt, O. Tomashenko, M. Novikov   +3 more
semanticscholar   +1 more source

ChemInform Abstract: AZIRINE PHOTOCHEMISTRY, CYCLIZATION OF 2‐STYRYL‐2H‐AZIRINES TO BENZAZEPINES

Chemischer Informationsdienst, 1974
AbstractDie Photolyse der isomeren Phenyl‐styryl‐azirine (I) führt zum Benzazepin (II), dessen Struktur durch Addition von Acetylendicarbonsäureester (III) zum Additionsprodukt (IV) bestätigt wird.
A. PADWA, J. SMOLANOFF
openaire   +1 more source