Results 41 to 50 of about 1,721 (198)

CuH-Catalyzed Regioselective Intramolecular Hydroamination for the Synthesis of Alkyl-Substituted Chiral Aziridines [PDF]

, 2017
This report details a general and enantioselective means for the synthesis of alkyl-substituted aziridines. This protocol offers a direct route for the synthesis of alkyl-substituted chiral aziridines from achiral starting materials.
Wang, Haoxuan, Yang, Jeffrey, Buchwald, Stephen Leffler   +2 more
core   +1 more source

2-Oxo-4H-imidazolium-1-acetamidate, neue stabilisierte Dipole aus Aminoazirinen und NH-aciden Heterocyclen

CHIMIA, 1985
3-Dimethylamino-2,2-dimethyl-2H-azirine (1) and 5-trifluoromethyl-1,3,4- oxadiazol-2(3H)-on (9) in 2-propanol react already at room temperature to give the dipolar compound 10 in reasonable yield (Scheme 4).
Roland Prewo, Jost H. Bieri, Heinz Heimgartner   +2 more
doaj   +1 more source

Neuere Methoden zur Ringerweiterung organischer Verbindungen

CHIMIA, 1980
The actual interest in the construction of cyclic compounds via ring expansion reactions is demonstrated in the first chapter by means of typical examples.
Heinz Heimgartner
doaj   +1 more source

A catalyst-controlled selective synthesis of pyridines and pyrroles [PDF]

, 2014
We have developed a dual reaction manifold that enables selective synthesis of both pyridines and pyrroles from common substrates ??-diazo oxime ethers.
Alvarez-Corral, Barluenga, Berry, Cano, Che, Chen, Colby, Collet, Collet, Dequirez, Dong, Driver, Gati, Gephart, Gritsan, Grondal, Hajos, Hinz, Huestis, Humenny, Jiang, Jiao-Jie, Karila, Lei, Li, Liu, Liu, Lourdusamy, Loy, Lu, Lu, Michael, Müller, Nakamura, Neely, Nicolaou, O'Hagan, Okamoto, Pozharskii, Qi, Qi, Qi, Rakshit, Ramirez, Roizen, Sakai, Sha, Shi, Shi, Skouta, Srimani, Stark, Wang, Wentrup, Xu, Zhang   +55 more
core   +1 more source

Investigation on the reactivity of α-azidochalcones with carboxylic acids: Formation of α-amido-1,3-diketones and highly substituted 2-(trifluoromethyl)oxazoles

Beilstein Journal of Organic Chemistry, 2015
The reaction of α-azidochalcones with carboxylic acids has been investigated resulting in the formation of α-amido-1,3-diketones under microwave irradiation via in situ formation of 2H-azirine intermediates.
Kandasamy Rajaguru, Arumugam Mariappan, Rajendran Suresh, Periasamy Manivannan, Shanmugam Muthusubramanian   +4 more
doaj   +1 more source

Kristallstruktur eines 2-Dimethylamino-3,3-dimethyl-4(3H)-pyridons

CHIMIA, 1982
3-Dimethylamino-2,2-dimethyl-2H-azirine (1) reacts with alkyl phenyl substituted cyclopropenones 2 in benzene at 130 °C to give a mixture of the two isomeric 4(3H)-pyridones 3 and 4, resulting from a nucleophilic attack at C(2) and C(1) of the ...
Jost H. Bieri, Roland Prewo, Heinz Heimgartner   +2 more
doaj   +1 more source

Benzene derivatives produced by Fusarium graminearum — Short communication [PDF]

, 2015
Using NMR spectroscopy benzene derivatives were detected in mycelia of Fusarium graminearum, a pathogen of wheat and maize. In previous studies F. graminearum was found to cause cancer to humans and benzene derivatives were detected in breath of cancer ...
Ntushelo, Khayalethu, Setshedi, Itumeleng   +1 more
core   +1 more source

Reaktionen von 3-Dimethylamino-2,2-dimethyl-2H-azirin mit aromatischen Carbonsäurehydraziden

CHIMIA, 1978
Reaction of 3-dimethylamino-2,2-dimethyl-2H-azirine (1) with salicylic acid hydrazide (2c) in acetonitrile at room temperature gives the amidrazone 3c as a primary product in 78% yield. Cyclization of 3c in methanol leads to the 1,2,5,6-tetrahydro-1,2,4-
Stanislav Chaloupka, Heinz Heimgartner
doaj   +1 more source

Chemical Metabolomics: Chemical Biology Tools for Advanced Metabolism Investigations

Angewandte Chemie International Edition, EarlyView.
The human metabolism has been investigated for several millennia. The metabolome is known for a high complexity due to a large number of different metabolites that are present at different concentrations. Metabolomics has been developed as a field to investigate the entire human metabolome and to elucidate disease development mechanisms.
Alejandro Torregrosa‐Chinillach, Ioanna Tsiara, Wawrzyniec Haberek, Weifeng Lin, Daniel Globisch   +4 more
wiley   +1 more source

Inductive queries for a drug designing robot scientist [PDF]

, 2010
It is increasingly clear that machine learning algorithms need to be integrated in an iterative scientific discovery loop, in which data is queried repeatedly by means of inductive queries and where the computer provides guidance to the experiments that ...
A. Lingas, C. Hansch, C.A. Lipinski, D.R. Jones, D.R. Jones, H. Blockeel, J. Matousek, L. Raedt De, R.D. King, R.D. King, T. Gärtner   +10 more
core   +1 more source