Results 51 to 60 of about 1,721 (198)

Synthesis of New 2-Halo-2-(1H-tetrazol-5-yl)-2H-azirines via a Non-Classical Wittig Reaction

Molecules, 2015
The synthesis and reactivity of tetrazol-5-yl-phosphorus ylides towards N-halosuccinimide/TMSN3 reagent systems was explored, opening the way to new haloazidoalkenes bearing a tetrazol-5-yl substituent.
Ana L. Cardoso, Carmo Sousa, Marta S. C. Henriques, José A. Paixão, Teresa M. V. D. Pinho e Melo   +4 more
doaj   +1 more source

(2‐Phosphinophenyl)aluminum Dichloride Complexes as Intramolecular Al/P Frustrated Lewis Pairs for Ketone, Ester, and Imine Activation

Chemistry – A European Journal, EarlyView.
Three 2‐phosphinophenylaluminum dichloride complexes were synthesized and characterized as novel intramolecular FLPs. These FLP systems exhibit high Lewis acidity and effectively activate challenging substrates including aliphatic ketones, imines, and esters. DFT analysis revealed that strain release and Al–P dynamics govern their reactivity. Abstract (
Yoshihiro Nishimoto, Hirotaka Okamoto, Makoto Yasuda   +2 more
wiley   +1 more source

Accurate ring strain energies of unsaturated three-membered heterocycles with one group 13–16 element [PDF]

, 2022
© 2022 The Authors. This manuscript version is made available under the CC-BY 4.0 license http://creativecommons.org/licenses/by/4.0/ This document is the Published Manuscript version of a Published Work that appeared in final form in Inorganic ...
Espinosa Ferao, Arturo, Rey Planells, Alicia   +1 more
core   +1 more source

Strain Release of 1‐Azabicyclo[1.1.0]butanes as a Gateway to Highly Functionalized Azetidines: New Strategies and Structural Motifs

Chemistry – A European Journal, EarlyView.
Over the past decade, the interest in azetidines has continuously risen, by virtue of their highly appealing pharmaceutical properties. Monocyclic, spirocyclic, and bridged azetidines can be accessed by leveraging 1‐azabicyclo[1.1.0]butanes as precursors.
Yuri Gelato, Philipp Natho, Marco Colella, Renzo Luisi   +3 more
wiley   +1 more source

Synthesis and reactivity of 2-halo-2H-azirines towards nucleophiles [PDF]

, 1997
Nucleophilic substitution reactions of 2-halo-2H-azirine with potassium phthalimide and aniline allowed the preparation of new substituted 2H-azirines.
Pinho e Melo, Teresa M. V. D., Lopes, Cláudia S. J., Gonsalves, António M. d'A. Rocha   +2 more
core   +1 more source

Global membrane protein interactome analysis using in vivo crosslinking and MS-based protein correlation profiling [PDF]

, 2016
We present a methodology using in vivo crosslinking combined with HPLC-MS for the global analysis of endogenous protein complexes by protein correlation profiling. Formaldehyde crosslinked protein complexes were extracted with high yield using denaturing
Andersen, Bai, Baker, Bombardier, Calderone, Campbell, Cox, Cox, Cox, Culi, Dinchuk, Dunkley, Fukushi, Guerrero, Harner, Havugimana, He, Heinz, Hjelmeland, Hsieh, Hu, Huang, Humphries, Kim, Kirkwood, Koch, Kristensen, Krogh, Kuo, Larance, Larance, Mueller, Nepusz, Oliphant, Orlando, Pedregosa, Reis, Rhee, Roux, Ruepp, Schey, Schmitt-Ulms, Sinz, Stenflo, Stryer, Stumpf, Supek, Swaney, Szklarczyk, Tagwerker, Vasilescu, Wan, Yang   +52 more
core   +2 more sources

Push–Pull Ynamines and Push–Pull Ynamides: Synthesis, Structure, Reactivity, and Application

European Journal of Organic Chemistry, EarlyView.
Push–pull ynamines and push–pull ynamides, which carry an EWG and an amino or amido group as EDG, are highly interesting classes of EDG‐EWG alkynes that have been intensively studied due to their exceptional reactivity. In this review, the synthesis, structure, reactivity, and application of push–pull ynamines, push–pull ynecarbamates, push–pull ...
Hans‐Joachim Gais
wiley   +1 more source

Molecular basis for functional switching of GFP by two disparate non-native post-translational modifications of a phenyl azide reaction handle [PDF]

, 2016
Through the genetic incorporation of a single phenyl azide group into superfolder GFP (sfGFP) at residue 148 we provide a molecular description of how this highly versatile chemical handle can be used to positively switch protein function in vitro and in
Hartley, Andrew M., Jones, D. Dafydd, Reddington, Samuel C., Rizkallah, Pierre J., Worthy, Harley L.   +4 more
core   +3 more sources

Light-induced synthesis of 2H-azirines and its applications in organic chemistry

Journal of Saudi Chemical Society
2H-azirines have represented versatile building motifs in the domain of organic chemistry owing to their excellent reaction activity induced by the high strain of the three-membered ring species.
Shibo Lin, Yiwen Chu, Junfeng Deng, Fangqing Xie, Lifeng Zhao   +4 more
doaj   +1 more source

1,1‐Disubstituted Vinylbromides: Versatile Building Blocks for the Synthesis of Nitrogen‐Containing Heterocycles

European Journal of Organic Chemistry, EarlyView.
1,1‐Disubstituted vinylbromides are key intermediates for constructing nitrogen‐containing heterocycles. This review provides an overview of the synthetic applications of 1,1‐disubstituted vinylbromides and summarizes recent developments in reaction methodologies, mechanistic insights, and the structural diversity of N‐heterocyclic compounds accessible
Anne Westermeyer, Jun Fang, Chonghuo Liu, Guillaume Lefèvre, Gérard Guillamot, Phannarath Phansavath, Virginie Ratovelomanana‐Vidal   +6 more
wiley   +1 more source