Results 51 to 60 of about 1,246 (202)

Chemical Metabolomics: Chemical Biology Tools for Advanced Metabolism Investigations

Angewandte Chemie, Volume 138, Issue 23, 1 June 2026.
The human metabolism has been investigated for several millennia. The metabolome is known for a high complexity due to a large number of different metabolites that are present at different concentrations. Metabolomics has been developed as a field to investigate the entire human metabolome and to elucidate disease development mechanisms.
Alejandro Torregrosa‐Chinillach, Ioanna Tsiara, Wawrzyniec Haberek, Weifeng Lin, Daniel Globisch   +4 more
wiley   +2 more sources

Synthesis of Aib-containing cyclopeptides via the 'azirine/oxazolone method' [PDF]

, 2009
The cyclic pentapeptide cyclo[Gly-Phe(2Me)-Aib-Aib-Gly], containing three α,α-disubstituted α-amino acids, was prepared by cyclization of H-Gly-Phe(2Me)-Aib-Aib-Gly-OH with diphenylphosporazidate (DPPA) in 60% yield. The synthesis of the linear precursor
Dannecker-Dörig, I, Linden, Anthony; https://orcid.org/, Heimgartner, H   +2 more
core   +1 more source

Ethyl 3-(2-pyridyl)-2H-azirine-2-carboxylate : synthesis and reactivity with dienes [PDF]

, 2012
Ethyl 3-(2-pyridyl)-2H-azirine-2-carboxylate, the first example of an 3-heteroamatic 2H-azirine has been prepared. The reaction of ethyl 3-(2-pyridyl)-2H-azirine-2-carboxylate with conjugated 1,3-dienes, under mild conditions and in the absence of ...
Alves, Maria José Chão, Lemos, A., Fortes, Gil, Martins, Cristina I.   +3 more
core  

Kupferkatalysierte, hochgradig enantioselektive Addition eines Siliciumnukleophils an 3‐substituierte 2H‐Azirine unter Verwendung eines Si‐B‐Reagenzes

, 2023
3-Substituierte 2H-Azirine können als gespannte cyclische Ketimine angesehen werden, und hochgradig enantioselektive Additionsreaktionen von Siliciumnukleophilen an acyclische und auch cyclische Ketimine sind bislang nicht erreicht worden.
Oestreich, Martin, Irran, Elisabeth, Zhao, Zhi‐Yuan, Cui, Ming   +3 more
core   +1 more source

Addition and Cycloaddition Reactions of Phosphinyl- and Phosphonyl-2H-Azirines, Nitrosoalkenes and Azoalkenes

Molecules, 2009
An overview of the use of 2H-azirines, conjugated nitrosoalkenes and conjugated azoalkenes bearing phosphorus substituents in addition and cycloaddition reactions is presented, focused on strategies for the synthesis of aminophosphonate and ...
Américo Lemos
doaj   +1 more source

Synthesis of 2-Aminonicotinonitriles via Photodecarboxylation of Azirine-2-Carboxylic Acids

Molbank
2-Aminonicotinonitriles represent an important class of heterocycles with diverse biological activities. Herein, we report an unexpected photochemical transformation of azirine-2-carboxylic acids leading to the formation of 2-aminonicotinonitrile ...
Julia I. Pavlenko, Mikhail S. Novikov, Anastasiya V. Agafonova   +2 more
doaj   +1 more source

Strain Release of 1‐Azabicyclo[1.1.0]butanes as a Gateway to Highly Functionalized Azetidines: New Strategies and Structural Motifs

Chemistry – A European Journal, Volume 32, Issue 31, 18 August 2026.
Over the past decade, the interest in azetidines has continuously risen, by virtue of their highly appealing pharmaceutical properties. Monocyclic, spirocyclic, and bridged azetidines can be accessed by leveraging 1‐azabicyclo[1.1.0]butanes as precursors.
Yuri Gelato, Philipp Natho, Marco Colella, Renzo Luisi   +3 more
wiley   +1 more source

Photochemistry of N‐Substituted, N′‐Tosyl Diphenyl Sulfondiimines

Journal of Physical Organic Chemistry, Volume 39, Issue 8, August 2026.
The irradiation of N‐substituted, N′‐tosyl diphenyl sulfondiimines with UV light induces the sequential photorelease of two different nitrenes. ABSTRACT Sulfondiimines are an emerging sulfur(VI) functional group with increasing use in synthesis and medicinal chemistry, yet their photochemical behavior has remained largely unexplored.
Bashar Aziz, Paul Danyi, John P. Carney, Ryan D. McCulla   +3 more
wiley   +1 more source

Singlet Photoreactivity of 3-Methyl-2-phenyl-2H-azirine

, 2017
Irradiation of 3-methyl-2-phenyl-2H-azirine (1) at 254 nm in argon matrices results in ylide 6. Similarly, laser flash photolysis (λ = 266 nm) of azirine 1 in acetonitrile yields ylide 6, which has a transient absorption with λmax at ~340 nm and a ...
Bruce S. Ault, Sujan K. Sarkar, Anna D. Gudmundsdottir, Anushree Das, H. Dushanee M. Sriyarathne, Xiaoming Zhang, Geethika K. Weragoda   +6 more
core   +1 more source

Funktionalisierung von Peptiden auf der festen Phase im späten Synthesestadium

Angewandte Chemie, Volume 138, Issue 31, 27 July 2026.
Peptidmodifikationen sind für die Kontrolle der Eigenschaften von Peptidwirkstoffen von entscheidender Bedeutung. Daher sind Strategien, die einen effizienten und schnellen Einbau nicht‐kanonischer Modifikationen in Peptide in Parallelformaten ermöglichen, sehr gefragt.
Marius Werner, Truc Lam Pham, Franziska Thomas   +2 more
wiley   +1 more source