Results 31 to 40 of about 428 (148)

Diversity-Oriented Synthesis of Dibenzoazocines and Dibenzoazepines via a Microwave-Assisted Intramolecular A³-Coupling Reaction

, 2016
An unprecedented, diversity-oriented strategy for the generation of 6,7-dihydro-5H-dibenzo[c,e]azepines and 5,6,7,8-tetrahydrodibenzo[c,e]azocines by a microwave-assisted copper-catalyzed intramolecular A3-coupling reaction is ...
Kristof Van Hecke (1574854), Toma N. Glasnov (2175588), Luc Van Meervelt (1501579), Denis S. Ermolat’ev (1950742), Erik V. Van der Eycken (1574857), Jitender B. Bariwal (2290846), C. Oliver Kappe (1264179), Vaibhav P. Mehta (1301115)   +7 more
core   +3 more sources

Conjugating Hemoglobin and Albumin by Strain‐Promoted Azide‐ Alkyne Cycloaddition

ChemBioChem, Volume 25, Issue 16, August 19, 2024.
Strain‐promoted azide‐alkyne cycloaddition (SPAAC) of site‐selectively cross‐linked human hemoglobin with specifically modified human serum albumin yields a structurally defined protein‐protein conjugate. A circulating solution of the conjugate can provide cooperative oxygen transport and maintain colloid osmotic pressure.
Chi Lee, Harriet Wenxin Chung, Ronald Kluger   +2 more
wiley   +1 more source

The first example of 4,7,8,9-tetrahydrothieno-[2,3-d]azocine synthesis by domino reaction of 4-aryl-4,5,6,7-tetrahydrothieno[3,2-c]pyridines with activated alkynes

, 2020
1-Aryl-substituted tetrahydrothieno[3,2-c]pyridines easily undergo domino reactions with activated alkynes, giving good yields of the corresponding tetrahydrothieno[2,3-d]azocines.
Chervyakova T.M., Tolkunova V.S., Tolkunov S.V., Borisova T.N., Varlamov A.V., Matveeva M.D., Voskressensky L.G., Galaktionova D.V., Eresko A.B.   +8 more
core   +2 more sources

Organocalcium Hydride-Catalyzed Intramolecular C(sp³)–H Annulation of Functionalized 2,6-Lutidines

, 2023
This work reports an intramolecular C(sp3)–H annulation of functionalized 2,6-lutidines catalyzed by an organocalcium hydride [{(DIPPnacnac)CaH(thf)}2] (DIPPnacnac = CH{(CMe)(2,6-iPr2–C6H3N)}2).
Xin Xu (11989), Xian Xu (119341), Shuo Li (143148), Qianlin Sun (7493477)   +3 more
core   +2 more sources

Synthesis of 6,12-Methanodibenzo[c,f]azocines and 4‑Aryltetrahydroisoquinolines from Aromatic Aldehydes

, 2019
A methodology for the synthesis of 7,12-dihydro-5H-6,12-methanodibenzo­[c,f]­azocines from aromatic aldehydes and N-(methoxymethyl)-N-(trimethylsilylmethyl)­benzylamine using catalysis by trifluoroacetic and perchloric acids is described.
Vladimir S. Moshkin (2582062), Evgeny M. Buev, Vladimir S. Moshkin, Vyacheslav Y. Sosnovskikh, Evgeny M. Buev (2582059), Maxim A. Stepanov (8208156), Vyacheslav Y. Sosnovskikh (2582056), Maxim A. Stepanov   +7 more
core   +1 more source

Transformations of tetrahydropyrido[4′,3′:4,5]thieno[2,3-d] pyrimidin-4(3H)-ones in the presence of alkynes bearing electron-withdrawing substituents

, 2020
Tetrahydropyrido[4′,3′:4,5]thieno[2,3-d]pyrimidines in the presence of activated alkynes were transformed into mixtures of pyrimido[5′,4′:4,5]thieno[3,2-d]azocines and spiro[pyridine-4, 5′-thieno[2,3-d]pyrimidines]. © 2012 Springer Science+Business Media
Khrustalev V.N., Ovcharov M.V., Kovaleva S.A., Kulikova L.N., Borisova T.N., Varlamov A.V., Voskressensky L.G., Listratova A.V.   +7 more
core   +2 more sources

A photochemical ring expansion of 6- to 8-membered nitrogen heterocycles by [1,3]-sigmatropic rearrangement

, 2021
A new route to azocines and benzoazocines from furopyridinones is described through a photochemically induced [1,3]-sigmatropic rearrangement. The method gives access to these 8-membered nitrogen heterocycles from dimethyl squarate in four stages and ...
Sun, Wei, Light, Mark, Harrowven, David C., Manning, Morgan A., David C. Harrowven, Wei Sun, Mark E. Light, Morgan A. Manning   +7 more
core   +1 more source

Transformations of 4,5,6,7-tetrahydrothieno[3,2-c]-and 1,2,3,4- tetrahydrobenzothieno[2,3-c]pyridines in reactions with alkynes activated by electron-withdrawing substituents

, 2020
The transformations of tetrahydrothieno[3,2-c]-and tetrahydrobenzothieno[2, 3-c]pyridines in the reactions with acetylenedicarboxylic ester, alkyl propiolates, and acetylacetylene in alcohols were studied.
Sorokina E.A., Tolkunov S.V., Borisova T.N., Varlamov A.V., Voskressensky L.G., Listratova A.V.   +5 more
core   +2 more sources

Interaction, bond formation or reaction between a dimethylamino group and an adjacent alkene or aldehyde group in aromatic systems controlled by remote molecular constraints

, 2021
Peri-peri interactions in naphthalene systems control the degree of bond formation between a peri-dimethylamino group and a polarised alkene or aldehyde group.
Bristow, Jonathan C., Cliff, Stacey V. A., Yang, Songjie, Wallis, John D., John D. Wallis, Jonathan C. Bristow, Stacey V. A. Cliff, Songjie Yang   +7 more
core   +1 more source

Diversity-oriented synthesis of dibenzoazocines and dibenzoazepines via a microwave-assisted intramolecular A3-coupling reaction

, 2010
An unprecedented, diversity-oriented strategy for the generation of 6,7-dihydro-5H-dibenzo[c,e]azepines and 5,6,7,8-tetrahydrodibenzo[c,e]azocines by a microwave-assisted copper-catalyzed intramolecular A(3)-coupling reaction is ...
Van Hecke, Kristof, Ermolat'ev, Denis S, Van der Eycken, Erik V, Glasnov, Toma N, Van Meervelt, Luc, Kappe, C Oliver, Bariwal, Jitender B, Mehta, Vaibhav P, Vaibhav P. Mehta, Jitender B. Bariwal, Denis S. Ermolat’ev, Luc Van Meervelt, Toma N. Glasnov, Kristof Van Hecke, C. Oliver Kappe, Erik V. Van der Eycken   +15 more
core   +1 more source