Results 71 to 80 of about 868 (168)

Straightforward Synthesis of Thiophene Bioisosteres of the Pyrrolo[3,2-c]quinoline Framework from Martinelline Alkaloids

open access: yesMolbank
We report the first green and diastereoselective synthesis of novel thiophene bioisosteres designed to mimic the privileged pyrrolo[3,2-c]quinoline core of martinelline alkaloids.
Tamer S. Saleh, Abdullah S. Al-Bogami
doaj   +1 more source

Glycine-Based [3+2] Cycloaddition for the Synthesis of Pyrrolidine-Containing Polycyclic Compounds

open access: yesMolecules
The synthesis of pyrrolidine compounds with biological interest is an active research topic. Glycine could be a versatile starting material for making pyrrolidine derivatives.
Tieli Zhou   +3 more
doaj   +1 more source

A Regioselective Multicomponent Approach for the Synthesis of Novel 2-Acetyl-4-phenylquinoline Designed Monospiro-Pyrrolidine and Thiapyrrolizidine Hybrids

open access: yesHeteroatom Chemistry
A convenient approach for the synthesis of 2-acetyl-4-phenylquinoline designed monospiro-pyrrolidine/thiapyrrolizidine hybrids has been achieved via a 1,3-dipolar cycloaddition reaction of various azomethine ylides derived from isatin/acenaphthylene-1,2 ...
Satheeshkumar Rajendran   +2 more
doaj   +1 more source

Decarboxylation-Driven Double Annulations: Innovative Multi-Component Reaction Pathways

open access: yesMolecules
A concerted five-component reaction strategy has been developed, featuring double [3+2] cycloadditions utilizing aspartic acid. This approach provides valuable insights into mechanistic pathways, allowing for the distinction between concerted and ...
Desheng Zhan   +4 more
doaj   +1 more source

Utilizing MEDT analysis of [3 + 2] cycloaddition reaction: x-ray crystallography of spirooxindole linked with thiophene/furan heterocycles and triazole framework

open access: yesBMC Chemistry
Hybridization of spirooxindole with different pharmacophores such as triazole and heterocycle such as thiophene and furan moiety was achieved by the [3 + 2] cycloaddition (32CA) reaction approach. Structural investigations of the compounds 4a and 4b were
Abdulmajeed Abdullah Alayyaf   +7 more
doaj   +1 more source

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