Results 21 to 30 of about 1,285 (142)

Inhibition of P‐glycoprotein using photoimmunotherapy in peritoneal metastasis mouse model

Photochemistry and Photobiology, EarlyView.
Photoimmunotherapy (PIT) using photoimmunoconjugates (PICs) can inhibit the function of the ATP‐binding cassette (ABC) transporter P‐glycoprotein (P‐gp) in a mouse model of peritoneal carcinomatosis. Sterile‐filtered PIC was administered in vivo via intraperitoneal (IP) injection 20 days after IP tumor cell implantation of P‐gp‐overexpressing NCI/ADR ...
Kaitlyn A. Moore, Brian Schnoor, Kathryn L. McNaughton, Idrisa Rahman, Benjamin D. Powers, Dana M. Roque, Huang‐Chiao Huang   +6 more
wiley   +1 more source

RAD51 and RAD51 paralog inhibition sensitizes nonreplicating quiescent keratinocytes to UV radiation

Photochemistry and Photobiology, EarlyView.
UV radiation and other compounds generate DNA adducts that block transcription and induce cell death if not removed by the nucleotide excision repair system. In this work, we used a small‐scale pharmacological screen to discover that inhibition of the recombinase RAD51 sensitized nonreplicating quiescent keratinocytes to both UVR and other agents that ...
Saman Khan, Angitha Nair, M. Alexandra Carpenter, Michael G. Kemp   +3 more
wiley   +1 more source

One day of environment‐induced heat stress causes injury to the murine kidney

Experimental Physiology, EarlyView.
Abstract Environment‐induced heat stress (EIHS) results from sustained body temperature elevation owing to prolonged exposure to heat and humidity. We hypothesized that EIHS would cause kidney injury and cellular dysfunction. To test this hypothesis, female C57 mice were exposed to EIHS (n = 14; 37.6°C, 42.0% relative humidity) or thermoneutral (TN ...
Melissa Roths, Alyona Michael, Zachary J. Schlader, Joshua T. Selsby   +3 more
wiley   +1 more source

Whole Wheat Flour Components Intervention Against Lead Toxicity: Impacts on Metal Bioavailability and Protection of the Intestinal Epithelial Barrier

Food Frontiers, Volume 7, Issue 5, September 2026.
ABSTRACT Consumption of whole wheat flour promotes lead excretion, yet the functional components reducing lead bioavailability and their protective mechanisms remain unclear. To identify these components and to validate whether their mechanism is related to protection of the intestinal barrier, this study established an in vitro model combining ...
Zhiyin Xiao, Tianhang Huang, Fengjiao Fan, Jian Ding, Xiaoyi Jiang, Xinyang Sun, Peng Li, Yong Fang   +7 more
wiley   +1 more source

Cervical screening in Western Kazakhstan: Liquid-based cytology ‘Cell Scan’ versus azur-eosin staining [PDF]

Journal of Medical Screening, 2019
Objective To assess the effectiveness of the current cervical cancer screening tools in Western Kazakhstan. Methods Smears taken through (i) conventional cytology using azur-eosin staining and (ii) liquid-based cytology (LBC) ‘Cell ...
Saule Balmagambetova, Giovanni Gabutti, Arip Koyshybaev, Cecilia Acuti Martellucci, Olzhas Urazayev, Kanshaiym Sakiyeva, Karlygash Bekova   +6 more
openaire   +4 more sources

Improved sodium dodecyl sulfate–polyacrylamide gel electrophoresis method for quantifying the 11S/7S ratio in soybean storage proteins

Journal of the Science of Food and Agriculture, Volume 106, Issue 12, Page 7163-7170, September 2026.
Abstract BACKGROUND Accurate quantification of soybean storage protein subunits glycinin (11S) and β‐conglycinin (7S), and their ratio (11S/7S), is essential for applications in plant breeding, food processing, and allergen research. Although sodium dodecyl sulfate–polyacrylamide gel electrophoresis (SDS‐PAGE) is widely used due to its accessibility ...
Yaojie Zheng, Cynthia Denbow, Matheus Ogando do Granja, Guillaume Pilot, Zhibo Wang, Maria Luciana Rosso, Bo Zhang   +6 more
wiley   +1 more source

Inducing Antigen‐Specific and Functional Immune Responses in Mice Toward Bovine Herpesvirus 1 and Bovine Respiratory Syncytial Virus by Chimeric Peptides Delivered by Bovine Herpesvirus 4‐Based Vector

Immunology, Volume 179, Issue 1, Page 54-71, September 2026.
Bovine Alphaherpesvirus 1 (BoHV‐1) and Bovine respiratory syncytial virus (BRSV) are major drivers of respiratory disease in cattle. (A) To target both pathogens, two chimeric antigens—membrane‐linked and secreted—combining BoHV‐1 glycoprotein D and BRSV fusion glycoprotein were designed and expressed using recombinant BoHV‐4‐based vectors.
Antonino Di Lorenzo, Sergio Minesso, Chiara Cossu, Valentina Franceschi, Elisabetta Bolli, Vittorio Madia, Laura Conti, Gaetano Donofrio   +7 more
wiley   +1 more source

Specific Knockdown of Gene Expression in the Mature Rat Pineal Gland: The Cone‐Rod Homeodomain Transcription Factor Regulates Melatonin Synthesis In Vivo

Journal of Pineal Research, Volume 78, Issue 5, September 2026.
ABSTRACT Melatonin is synthesised from tryptophan by the sequential action of enzymes that are highly expressed in the pineal gland. Homeobox gene‐encoded transcription factors typically control organ development; however, a set of homeobox genes is strongly expressed in the adult pineal gland.
Nicole Anne Morrissey, Tenna Bering, Aurea Susana Blancas‐Velázquez, Jakob Albrethsen, Nicolai J. Wewer Albrechtsen, Martin Fredensborg Rath   +5 more
wiley   +1 more source

Diosgenin Alleviates Age‐Related Sarcopenia by Promoting Satellite Cell Proliferation and Myogenic Differentiation via Activation of the SIRT1/PGC‐1α Signaling Pathway

Aging Cell, Volume 25, Issue 8, August 2026.
As a critical bioactive component of Polygonatum sibiricum, diosgenin improves age‐related declines in skeletal muscle mass and function by activating the SIRT1/PGC‐1α pathway, upregulating the expression of the myokine METRNL and IGF‐1, and promoting satellite cell proliferation and myogenic differentiation.
Xin Zeng, Han Ding, Ziye Li, Qian Wang, Peiyao Guan, Tingting Wang, Jiayun Wang, Yansong Fu, Lizhang Chen, Hong Qin   +9 more
wiley   +1 more source

A high‐fat, high‐sucrose diet exacerbates muscle and metabolic pathology and undermines glucocorticoid efficacy in dystrophin‐deficient mice

The Journal of Physiology, Volume 604, Issue 15, Page 6440-6464, 1 August 2026.
Abstract figure legend A high‐fat, high‐sucrose diet (HFHSD) exacerbated muscle and metabolic dysregulation in mdx mice while also altering the physiological response to prednisolone (Pred) In diaphragms of control diet (CD)‐fed mdx mice, prednisolone treatment improved muscle function and reduced fibrosis, inflammatory signalling, and mitochondrial ...
Morgan E. Vorwald, Swathy Krishna, Ji Heun Lee, Melissa Roths, Rudy J. Valentine, Joshua T. Selsby   +5 more
wiley   +1 more source