Results 61 to 70 of about 863,145 (246)

Automodification of N‐terminal serine residues facilitates PARP2 release from DNA

The FEBS Journal, EarlyView.
PARP2 is involved in detecting DNA damage and its N‐terminal role is largely unknown. Based on biochemical and biophysical data, our findings suggest that in the presence of HPF1, N‐terminal serine 8 and 73 are enriched in auto‐ADP‐ribosylation. Our results provide insight into the mechanistic role of PARP2 N‐terminus in the PARylation‐dependent ...
Saurabh Singh Dhakar, Albert Galera‐Prat, Jin Cai, Julia Preisser, Tiila‐Riikka Kiema, Andreas Ladurner, Lari Lehtiö   +6 more
wiley   +1 more source

Tinción con Azul Brillante de Cresilo en secciones vegetales con parafina [PDF]

, 2002
El desarrollo de métodos para la realización de preparados histológicos para la observación con microscopio óptico, tanto destinados a la investigación como a la docencia, aún ocupa hoy un lugar importante en microtécnica botánica.
Perez, Adriana Nelida, Tomasi, Victor Hugo   +1 more
core  

Imaging malaria parasites across scales and time

Journal of Microscopy, EarlyView.
Abstract The idea that disease is caused at the cellular level is so fundamental to us that we might forget the critical role microscopy played in generating and developing this insight. Visually identifying diseased or infected cells lays the foundation for any effort to curb human pathology.
Julien Guizetti
wiley   +1 more source

The retardation of growth in A. aegypti (L.) larvae exposed to the vital dyes methylene blue and neutral red. [PDF]

, 1969
Thesis (M.S.
Barbosa, Pedro
core   +2 more sources

Strain, procedures, and tools for reproducible genetic transformation and genome editing of the emerging plant model Spirodela polyrhiza

New Phytologist, EarlyView.
Summary Duckweeds (Lemnaceae) have excellent potential for fundamental and applied research due to ease of cultivation, small size, and continuous fast clonal growth. However, their usage as model organisms and platforms for biotechnological applications is often limited by the lack of universal genetic manipulation methods necessary for transgene ...
Verónica Barragán‐Borrero, Amanda de Santana Lopes, Enrico Diniz Rodrigues Batista, Martin Höfer, Rana Elias, Abhisek Chakraborty, Arturo Ponce‐Mañe, Clotilde Descombes, Laura Diezma‐Navas, Lydia Petraki, Meret Huber, Shuqing Xu, Arturo Marí‐Ordóñez   +12 more
wiley   +1 more source

One day of environment‐induced heat stress causes injury to the murine kidney

Experimental Physiology, EarlyView.
Abstract Environment‐induced heat stress (EIHS) results from sustained body temperature elevation owing to prolonged exposure to heat and humidity. We hypothesized that EIHS would cause kidney injury and cellular dysfunction. To test this hypothesis, female C57 mice were exposed to EIHS (n = 14; 37.6°C, 42.0% relative humidity) or thermoneutral (TN ...
Melissa Roths, Alyona Michael, Zachary J. Schlader, Joshua T. Selsby   +3 more
wiley   +1 more source

AAV Assembled Capsids Are Produced in Cells Blocked From Cell Cycle Progression

Biotechnology and Bioengineering, Volume 123, Issue 2, Page 273-286, February 2026.
ABSTRACT Adeno‐associated virus (AAV) is a promising delivery system for gene therapy. However, current manufacturing of AAV suffers from very low yields compared to other biotherapeutics. The AAV dose per patient ranges between 1011and 1015 viral genomes (vg), requiring an average of 10 to 30 L production/dose.
Alaka Mullick, Audrey Morasse, Melanie Leclerc, Ziying Liu, Qing Yan Liu, Sonia Leclerc, Milica Momcilovic, Annie Viau, Amine A. Kamen   +8 more
wiley   +1 more source

Differentiation Treatment Applied to Lung Cancer Model Reduces Pathogenic Traits in Vitro

Advanced Biology, Volume 10, Issue 1, January 2026.
Non‐small cell lung cancer cells (A549) treated with a differentiation medium showed strong reduction in proliferation, migration, clonogenicity, spheroid formation and stemness markers, with enhanced adhesion properties and alveolar features, all pointing to a notably less aggressive phenotype in support of differentiation therapy as a promising ...
Alice Grossi, Paola Fulghieri, Abdurakhmon Aduvaliev, Karen Soffiantini, Irene Oldrati, Margherita Cavallo, Marco Biggiogera, Giorgia Pellavio, Umberto Laforenza, Monica Savio, Virginie Sottile   +10 more
wiley   +1 more source

Elevated Apolipoprotein E Expression in Hippocampal Microglia Drives Temporal Lobe Epilepsy Progression

Advanced Science, Volume 13, Issue 2, 9 January 2026.
In temporal lobe epilepsy, hippocampal APOE is markedly upregulated predominantly in microglia. APOE overexpression in microglia drives TLR4 and cGAS/STING‐dependent neuroinflammation, engages bidirectional crosstalk with neurons and astrocytes, increases neuronal excitability, and perturbs hippocampal lipid metabolism. These findings suggest that APOE‐
Jianwei Shi, Zesheng Li, Xin Sun, Yanfeng Yang, Yumin Luo, Ziang Song, Hengxin Dong, Lei Jin, Jing Xie, Yongzhi Shan, Guoguang Zhao   +10 more
wiley   +1 more source

Stress reaction of kidney epithelial cells to inorganic solid-core nanoparticles [PDF]

, 2018
A route of accumulation and elimination of therapeutic engineered nanoparticles (NPs) may be the kidney. Therefore, the interactions of different solid-core inorganic NPs (titanium-, silica-, and iron oxide-based NPs) were studied in vitro with the MDCK ...
Chapuis Bernasconi, Catherine, Halamoda Kenzaoui, Blanka, Juillerat-Jeanneret, Lucienne   +2 more
core