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Comprehensive SummaryModified nucleosides, particularly those with 4'‐modifications, are significant nucleosides used in antiviral treatments. The drug discovery campaign of Azvudine starts from 2′‐deoxynucleoside, followed by extensive modifications, such as introducing the 4’‐position substitutions, a 2’‐β‐fluoro atom, and changing the nucleobases ...
Bin Yu, Junbiao Chang
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Abstract 6493: Azvudine combined with Doxitinib, a potential therapy for EGFRm+ NSCLC
Cancer ResearchAbstract Osimertinib, a third-generation EGFR tyrosine kinase inhibitor (EGFR-TKI), is the current standard first-line therapy for patients with EGFR-mutant non-small cell lung cancer (NSCLC). Although Osimertinib significantly improves progression-free survival (PFS), some patients exhibit intrinsic resistance, and nearly all ...
Jianmei Zhang +7 more
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A Retrospective Study on Azvudine in Hospitalized Elderly Patients with COVID-19
CoronavirusesBackground: The ongoing 2019 novel coronavirus pneumonia pandemic continues to pose a serious threat to public health and safety. In response, numerous specific anti-SARS-CoV-2 drugs have been urgently approved for use. Azvudine has been recommended as a priority treatment for COVID-19 patients, but its efficacy and safety in elderly patients remain ...
Ruifang Nie +4 more
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Real‐world effectiveness of azvudine: Elixir or equivocal answer?
Journal of Medical Virology, 2023Yuan Gao +3 more
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Abstract 3866: Azvudine: An emerging immunomodulator in the treatment of cancer and viral infections
Cancer ResearchAbstract Azvudine (FNC) is a nucleoside analog that has secured approval from the CDE in China for the treatment of both AIDS and COVID-19. In these contexts, it has showed remarkable efficacy and safety when taken orally. Typically, nucleoside analog drugs function by integrating into DNA and impeding DNA synthesis, evident in drugs ...
Pan Li +3 more
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Evaluate clinical effectiveness of Azvudine with data rather than speculation
Journal of Medical Virology, 2023Guangtong Deng +3 more
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