Results 101 to 110 of about 36,513 (260)

Queer Nightlife and Contemporary Art Networks: A Study of Artists at the Bar

Arts
This article positions queer nightlife as a central vehicle in the lives and practices of queer Latinx artists working in Los Angeles over the past decade.
Joseph Daniel Valencia
doaj   +1 more source

A stochastic dynamic mass spectrometric diffusion method and its application to 3D structural analysis of the analytes

Reviews in Analytical Chemistry, 2019
There is a straightforward line in the recent development of the functional model connecting the experimental mass spectrometric variable intensity of a peak of an analyte ion with its thermodynamic, kinetic and diffusion parameters.
Ivanova Bojidarka, Spiteller Michael
doaj   +1 more source

PAK1 activation drives divergent resistance mechanisms to aromatase inhibition and tamoxifen in a luminal: A breast cancer model

Molecular Oncology, EarlyView.
Breast cancer remains a major cause of cancer death in women, frequently developing endocrine therapy resistance. This study demonstrates that upregulated p21‐activated kinase 1 (PAK1) activity drives resistance to tamoxifen and long‐term estrogen deprivation in ER+ breast cancer models.
Luisa Schwarzmüller, Janina Müller, Efstathios‐Iason Vlachavas, Lukas Beumers, Lena Fleischhacker, Sara Burmester, Angelika Wörner, Sabine Karolus, Dominic Helm, Cindy Körner, Stefan Wiemann   +10 more
wiley   +1 more source

Spatial and single‐nuclei transcriptomics reveals idiosyncratic and generic patterns in papillary and anaplastic thyroid cancers

Molecular Oncology, EarlyView.
Matched spatial transcriptomics and single‐nuclei RNA‐seq were generated for anaplastic and BRAFV600E papillary thyroid cancers revealing generic and tumor‐specific states occurring in cancer cells and in the tumor microenvironment. In this context, cancer dedifferentiation mirrored organoid maturation through ordered thyroid marker gain/loss ...
Adrien Tourneur, Joel Rodrigues Vitória, Manuel Saiselet, Ligia Craciun, Denis Larsimont, Anne Lefort, Frédérick Libert, Carine Maenhaut, Sabine Costagliola, Maxime Tarabichi, Mirian Romitti, Vincent Detours   +11 more
wiley   +1 more source

Characterization of Fruit Vinegars via Bioactive and Organic Acid Profile Using Chemometrics. [PDF]

Foods, 2023
Yildiz E.
europepmc   +1 more source

Inhibition of cyclin‐dependent kinases 12/13 using CT7439 as a treatment for colorectal cancer with CDK12 upregulation

Molecular Oncology, EarlyView.
The proposed mechanism of action for the CDK12/13 inhibitor and cyclin K degrader, CT7439. CDK12/13 inhibition interrupts transcription elongation, leading to increased DNA damage that results in cell death. This agent is a potentially novel treatment option for patients with colorectal cancer. Created in BioRender. Cyclin‐dependent kinase (CDK) 12 and
Wylie K. Watlington, Divya L. Dayanidhi, Mohammad Zokaasadi, John B. Mantyh, Pelumi D. Olawuni, Gabrielle Rupprecht, Jeremy M. Force, Shannon McCall, Ashwani K. Bahl, David S. Hsu, Jason A. Somarelli   +10 more
wiley   +1 more source

A Millimeter-Scale Bar-Type Ultrasonic Motor Operating in Bending-Bending Vibration Modes

Actuators
Small satellite constellations are becoming increasingly integrated with emerging services such as cloud computing and big data, which imposes strict requirements on compactness, light weight, low-power consumption, and high integration of space ...
Zhanmiao Li, Xingyu Yi, Lei Yang, Gang Zhou, Shuxiang Dong   +4 more
doaj   +1 more source

Felsefe'-i târîhiyye:büyük Frederik, Prusya, devlet-i 'aliyye

, 1921
Taha Toros Arşivi, Dosya No: 242-Ali Kemal-Zeki-Sinan KuneralpMüellifin "Medhal-i Mes'ele'-i Şarkiyye"deki: "Felsefe'-i Târîhiyye, ya'nî bir tefsîr-i 'umûmîye göre; tedkîk-i vekâyi'-i mâzî ile keşf-i hakâ'ik-ı âtî merâkı bir zamân müverrihlerce pek mu ...
Ali Kemal
core  

In vitro and in silico modelling of ROS1‐positive non‐small cell lung cancer reveals fusion‐dependent tyrosine kinase inhibitor responses

Molecular Oncology, EarlyView.
Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq, Marc Terrones, Felicia Rodrigues Fortes, Anne Schepers, Alessia Denis, Christophe Deben, Ken Op de Beeck, Guy Van Camp, Geert Vandeweyer   +8 more
wiley   +1 more source

Green Extraction Strategies and Bioactivity of Rheum cordatum Losinsk: Antioxidant, Antimicrobial, and Molecular Docking Insights

Plants
This study aimed to compare the efficiency of different green extraction methods for obtaining bioactive compounds from the roots of Rheum cordatum Losinsk and to evaluate their antioxidant and antimicrobial properties.
Madina Amangeldinova, Mehmet Ersatır, Adem Necip, Mehmet Cimentepe, Nataliya Kudrina, Nina Terletskaya, Ozge Oztürk Cimentepe, Oguz Cakır, Mustafa Abdullah Yilmaz, Metin Yildirim   +9 more
doaj   +1 more source