Results 81 to 90 of about 36,513 (260)

Developmental programmes drive cellular plasticity, disease progression and therapy resistance in lung adenocarcinoma

Molecular Oncology, EarlyView.
This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska, Stephany Gallardo, Nur S. Zainal, Leena Arora, Matthew Ellis, Maria‐Antoinette Lopez, Judith Austine, Sai Pittla, Serena J Chee, Aiman Alzetani, Emily C Shaw, Christian H Ottensmeier, Gareth J Thomas, Christopher J Hanley   +13 more
wiley   +1 more source

Digital Bardo: Reimagining the Tibetan Book of the Dead in Virtual Identity and Consciousness Transformation

Religions
The Bardo Thodol (bar do thos grol), commonly known in the West as The Tibetan Book of the Dead, has traditionally served as a spiritual manual guiding consciousness through the postmortem bardo (bar do) states toward liberation or rebirth.
Hong Zeng, Saidi Su
doaj   +1 more source

İmam-ı Azam Ebu Hanife’nin Kur’an Anlayışı

, 2017
Ebû Hanîfe, İslâm düşüncesinin teşekkül devrinde yaşayan ve ortaya koyduğu fikirlerle de o dönemin düşünce hayatına yön veren önemli bir şahsiyettir. Bu yüzden onunla ilgili yapılan her bir çalışma için, öncelikle o dönemde tartışılıp olgunlaşmış olan ...
Tok, Fatih
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Edebiyyât-ı Osmâniyye [PDF]

, 2019
Bu kelime aslında zarafet, usluluk, söz ve harekette insanlara güzel davranış ve karşılıklı olarak iyilik yapma anlamındadır. Bazı kişiler de bu kelimeyi her çeşit hatadan sakınacak şeyleri bilmekten ibarettir, diyerek açıklamışlardır.
Karagözlü, Volkan
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Stimulator of interferon genes agonist augmented antitumor immunity of osimertinib in Egfr‐mutated lung cancer

Molecular Oncology, EarlyView.
Combining osimertinib with the STING agonist ADU‐S100 activates innate and adaptive immunity to overcome the non‐inflamed microenvironment of Egfr‐mutant lung cancer. This combination increases NK and CD8+ T‐cell infiltration, associated with activation of the STING‐IRF3 pathway and local immunogenic cell death.
Jun Nishimura, Tadahiro Kuribayashi, Johannes Brägelmann, Sachi Okawa, Masataka Taoka, Shunta Mori, Tomoka Nishimura, Takaaki Tanaka, Go Makimoto, Kiichiro Ninomiya, Kammei Rai, Eiki Ichihara, Ryohei Katayama, Katsuyuki Hotta, Masahiro Tabata, Yosuke Togashi, Yoshinobu Maeda, Martin L. Sos, Katsuyuki Kiura, Kadoaki Ohashi   +19 more
wiley   +1 more source

İttihad-ı İslam Siyaseti

Mutasavvıf ve düşünür Filibeli Ahmed Hilmi’nin II. Meşrutiyet’in ilanını takiben İstanbul’a dönmesinin ardından çıkarmaya başladığı haftalık gazete olan İttihâd-ı İslâm, “Haftada bir defa neşr olunur.

core   +1 more source

Loss of IGF‐1R impairs DNA‐PKcs recruitment to chromatin leading to defective end‐joining

Molecular Oncology, EarlyView.
IGF‐1R promotes radioresistance by facilitating DNA‐PKcs recruitment to chromatin, enabling non‐homologous end‐joining (NHEJ) repair of double‐strand breaks. Inhibition or loss of IGF‐1R disrupts this recruitment to damage sites, driving compensatory reliance on microhomology‐mediated end‐joining (MMEJ) repair.
Matthew O. Ellis, Jack V. Mills, Wojciech Niedzwiedz, Valentine M. Macaulay   +3 more
wiley   +1 more source

A Novel P-III Metalloproteinase from Bothrops barnetti Venom Degrades Extracellular Matrix Proteins, Inhibits Platelet Aggregation, and Disrupts Endothelial Cell Adhesion via α5β1 Integrin Receptors to Arginine–Glycine–Aspartic Acid (RGD)-Containing Molecules

Toxins
Viperid snake venoms are notably abundant in metalloproteinases (proteins) (SVMPs), which are primarily responsible for inducing hemorrhage and disrupting the hemostatic process and tissue integrity in envenomed victims.
Pedro Henrique de Caires Schluga, Debora Larangote, Ana Maria de Melo, Guilherme Kamienski Lobermayer, Daniel Torrejón, Luciana Souza de Oliveira, Valeria Gonçalves Alvarenga, Dan Erick Vivas-Ruiz, Silvio Sanches Veiga, Eladio Flores Sanchez, Luiza Helena Gremski   +10 more
doaj   +1 more source

The influence of the sodium silicate admixture on the pumped concrete flowability in pipelines / Natrio silikato tirpalo priedo poveikis siurbliais transportuojamo betono mišinio tekamumui vamzdžiais

Engineering Structures and Technologies, 2013
In the research experimental studies of the effect sodium silicate solution (NST) and plasticizer admixtures have on concrete mixture pipe flow velocity and capacity during of the transportation of mixtures with the “S”-type valve concrete pump with two ...
Mindaugas Daukšys, Gintautas Skripkiūnas, Audrius Grinys, Marija Vaičienė   +3 more
doaj   +1 more source

Kur’an-ı Kerim’in İkili Anlatım Üslubu Bağlamında Tergib ve Terhib

, 2017
Kur’an-ı Kerîm insanlığa beşer dilinin imkânlarıyla hitap etmiş ve kullandığı dilin anlam değiştirerek veya genişleterek insanlık ufkunda büyük bir dönüşüm gerçekleşmiştir.
Görmez, Hatice
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