Results 81 to 90 of about 65,038 (202)

Autoimmunity promotes chronic lymphocytic leukemia progression in an indolent disease model

Scientific Reports
Chronic lymphocytic leukemia (CLL) is a heterogeneous B cell malignancy characterized by the accumulation of functionally incompetent B lymphocytes.
Lisa Pfeuffer, Viola Siegert, Riccardo Trozzo, Katja Steiger, Roland Rad, Jürgen Ruland, Maike Buchner   +6 more
doaj   +1 more source

Alterations in TP53, cyclin D2, c-Myc, p21WAF1/CIP1 and p27KIP1 expression associated with progression in B-CLL.

Folia Histochemica et Cytobiologica, 2011
B-cell chronic lymphocytic leukaemia (B-CLL) originates from B lymphocytes that may differ in the activation level, maturation state or cellular subgroups in peripheral blood.
Marzec-Kotarska Barbara, Paterski Artur, Antosz Halina, Sajewicz Joanna, Dmoszyńska Anna   +4 more
doaj   +1 more source

Caspase 8 activation independent of Fas (CD95/APO-1) signaling may mediate killing of B-chronic lymphocytic leukemia cells by cytotoxic drugs or gamma radiation. [PDF]

, 2001
Ligation of the cell-surface Fas molecule by its ligand (Fas-L) or agonistic anti-Fas monoclonal antibodies results in the cleavage and activation of the cysteine protease procaspase 8 followed by the activation of procaspase 3 and by apoptosis.
Folarin, NI, Ganeshaguru, K, Hoffbrand, AV, Jones, DT, Lowdell, MW, Mehta, AB, Prentice, HG, Virchis, AE, Wickremasinghe, RG   +8 more
core  

Multimodal Image Analysis of Chronic Leukemic Lymphoproliferative Disorders and the Hypothesis of »Single« and »Multiple« Programmed Stops in the Development of Typical and Atypical Forms of Leukemias and Lymphomas [PDF]

, 2010
The study consisted of morphometric analysis, assessment of the argyrophilic nucleolar organization region (AgNOR) characteristics, and image cytometry (ICM) in different tumor mass compartments: bone marrow (BM), peripheral blood (PB) and lymph nodes ...
Biljana Jelić Puškarić, Branimr Jakšić, Delfa Radić-Krišto, Ika Kardum-Skelin, Matko Kardum, Ozren Jakšić   +5 more
core   +2 more sources

Cytotoxic CD4+ T cells in patients with B cell chronic lymphocytic leukemia kill via a perforin-mediated pathway [PDF]

Background and Objectives: B-cell chronic lymphocytic leukemia (B-CLL) is a clonal expansion of CD5+B cells that accumulate due to their uncontrolled growth and resistance to apoptosis.
Akbar, A., Akbar, A., Glennie, M.J., Glennie, M.J., Jewell, A.P., Jewell, A.P., Kardava, L., Kardava, L., Lydyard, P.M., Lydyard, P.M., Porakishvili, N., Porakishvili, N., Yong, K.L., Yong, K.L.   +13 more
core  

Correlation of del13q, del11q and Trisomy 12 with Laboratory and Clinical Features of Chronic Lymphocytic Leukemia in Iranian Patients [PDF]

, 2010
Background: There is a strong association between chromosomal abnormalities and laboratory features and clinical course of the B-cell chronic lymphocytic leukemia (B-CLL).
Akbari, mohammad taghi., Khaleghian, Maliheh., Teimori, Hossein., Toogeh, Gholamreza.   +3 more
core  

An unappreciated cell survival-independent role for BAFF initiating chronic lymphocytic leukemia

Frontiers in Immunology
BackgroundChronic Lymphocytic Leukemia (CLL) is characterized by the expansion of CD19+ CD5+ B cells but its origin remains debated. Mutated CLL may originate from post-germinal center B cells and unmutated CLL from CD5+ mature B cell precursors ...
Md Ashik Ullah, Beatriz Garcillán, Eden Whitlock, William A. Figgett, William A. Figgett, Simona Infantino, Mahya Eslami, Mahya Eslami, SiLing Yang, M. Arifur Rahman, Yong H. Sheng, Nicholas Weber, Pascal Schneider, Constantine S. Tam, Constantine S. Tam, Fabienne Mackay, Fabienne Mackay, Fabienne Mackay, Fabienne Mackay   +18 more
doaj   +1 more source

A comprehensive microarray-based DNA methylation study of 367 hematological neoplasms [PDF]

, 2011
Background: Alterations in the DNA methylation pattern are a hallmark of leukemias and lymphomas. However, most epigenetic studies in hematologic neoplasms (HNs) have focused either on the analysis of few candidate genes or many genes and few HN entities,
Agirre, Xabier, Alvarez, Sara, Ammerpohl, Ole, Bibikova, Marina, Brüggemann, Monika, Bug, Stefanie, Calasanz, Maria J., Cruz Cigudosa, Juan, Deckert, Martina, Dreyling, Martin, Du, Ming Q., Dyer, Martin J. S., Dürig, Jan, Fan, Jian-Bing, Gesk, Stefan, Haferlach, Claudia, Hansmann, Martin-Leo, Harder, Lana, Hartmann, Sylvia, Klapper, Wolfram, Küppers, Ralf, Martin-Subero, Jose Ignacio, Montesinos-Rongen, Manuel, Nagel, Inga, Pott, Christiane, Prosper, Felipe, Richter, Julia, Román-Gómez, José, Seifert, Marc, Siebert, Reiner, Stein, Harald, Suela, Javier, Trümper, Lorenz, Vater, Inga, Wickham-Garcia, Eliza   +34 more
core  

B cell receptor signaling and associated pathways in the pathogenesis of chronic lymphocytic leukemia

Frontiers in Oncology
B cell antigen receptor (BCR) signaling is a key driver of growth and survival in both normal and malignant B cells. Several lines of evidence support an important pathogenic role of the BCR in chronic lymphocytic leukemia (CLL).
Vera K. Schmid, Elias Hobeika
doaj   +1 more source

Expanded and activated allogeneic NK cells are cytotoxic against B-chronic lymphocytic leukemia (B-CLL) cells with sporadic cases of resistance. [PDF]

Sci Rep, 2020
Calvo T, Reina-Ortiz C, Giraldos D, Gascón M, Woods D, Asenjo J, Marco-Brualla J, Azaceta G, Izquierdo I, Palomera L, Sánchez-Martínez D, Marzo I, Naval J, Vilches C, Villalba M, Anel A.   +15 more
europepmc   +1 more source