Results 81 to 90 of about 12,336,620 (246)

Sustainability in Business Process Management: Research Landscape and Theoretical Implications

Sustainable Development, EarlyView.
ABSTRACT Sustainability in Business Process Management (BPM) is a growing priority for organisations seeking to balance operational efficiency with environmental and social responsibility. Although research highlights the benefits of integrating sustainability into BPM—such as regulatory compliance, cost reduction and corporate reputation enhancement ...
Silvia Dallavalle, João Henrique Paulino Pires Eustachio, Walter Leal Filho, Maria Laura Salomão David, Alexandre Rodrigues Cajuela, Lara Letícia Donegá Carreira   +5 more
wiley   +1 more source

Fludarabine and prednisone in pretreated refractory B-chronic lymphocytic leukemia (B-CLL) in advanced stages

, 1993
Background. The use of fludarabine, an analog of vidarabine with significant lymphocytolytic activity, has provided encouraging results in the treatment of patients with non Hodgkin's lymphoma (NHL) and sometimes in phase II studies of solid tumors and ...
MANDELLI, Franco, MAURO, Francesca Romana, G. DE ROSSI, R. CARUSO, B. MONARCA   +4 more
core  

Expression of HS1 protein in CLL B lymphocytes.

, 2013
The lysates obtained from normal B lymphocytes and leukemic B cells from CLL patients were analyzed by immunostaining with antibody against HS1. Blots were reprobed with anti-β-actin antibody as loading control.
Anna Cabrelle (8735), Elena Tibaldi (317618), Anna Maria Brunati (317620), Livio Trentin (317624), Gianpietro Semenzato (287054), Renato Zambello (317614), Antonella Teramo (317603), Federica Frezzato (317597), Veronica Martini (317600), Elisa Ave (317609), Valentina Trimarco (317602), Monica Facco (8734), Samuela Carraro (317605), Cristina Gattazzo (317598)   +13 more
core   +1 more source

Targeting the CD47–SIRPα phagocytic checkpoint in cancer: Biology, translational opportunities, and next‐generation therapeutic strategies

Smart Molecules, EarlyView.
The CD47–SIRPα axis has emerged as a critical innate immune checkpoint that suppresses macrophage‐mediated phagocytosis through a canonical “don't eat me” signal and enables tumor immune evasion. We comprehensively summarize the structural and biological features of CD47 and the molecular mechanisms underlying CD47‐mediated regulation of phagocytosis ...
Ruimei Zhou, Lingjie Jing, Jianping Zhang, Cheng Guo, Quanjun Yang   +4 more
wiley   +1 more source

Global distribution of DNA hydroxymethylation and DNA methylation in chronic lymphocytic leukemia

Epigenetics & Chromatin, 2019
Background Chronic lymphocytic leukemia (CLL) has been a good model system to understand the functional role of 5-methylcytosine (5-mC) in cancer progression.
Sara Wernig-Zorc, Mukesh Pratap Yadav, Pradeep Kumar Kopparapu, Mats Bemark, Hallgerdur Lind Kristjansdottir, Per-Ola Andersson, Chandrasekhar Kanduri, Meena Kanduri   +7 more
doaj   +1 more source

Nanomedicine applications in lymphoma: Advancing precision diagnostics, targeted therapeutics, and prospective developments

VIEW, EarlyView.
Lymphoma is a group of blood cancers that can appear in lymph nodes, blood, bone marrow, spleen, liver, or the central nervous system, which makes drug delivery and disease monitoring difficult. This review summarizes how nanomedicine technologies may improve targeted treatment and imaging, while carefully separating approved or guideline‐supported ...
Mohd Ahmar Rauf, Yara Mashal, Afeefa Rao, Nasar Ata, Arun K. Iyer, Farhan Shah   +5 more
wiley   +1 more source

CD47 agonist peptides induce programmed cell death in refractory chronic lymphocytic leukemia B cells via PLCγ1 activation: evidence from mice and humans.

PLoS Medicine, 2015
BackgroundChronic lymphocytic leukemia (CLL), the most common adulthood leukemia, is characterized by the accumulation of abnormal CD5+ B lymphocytes, which results in a progressive failure of the immune system.
Ana-Carolina Martinez-Torres, Claire Quiney, Tarik Attout, Heloïse Boullet, Linda Herbi, Laura Vela, Sandrine Barbier, Danielle Chateau, Elise Chapiro, Florence Nguyen-Khac, Frédéric Davi, Magali Le Garff-Tavernier, Roba Moumné, Marika Sarfati, Philippe Karoyan, Hélène Merle-Béral, Pierre Launay, Santos A Susin   +17 more
doaj   +1 more source

Expression of HS1 mRNA in CLL B lymphocytes.

, 2013
RNA extracted from normal B lymphocytes and leukemic B cells from CLL patients were analyzed for HS1 expression and normalized on GAPDH. Figure 2A shows HS1 mRNA expression of 30 CLL patients and 8 normal controls.
Anna Cabrelle (8735), Elena Tibaldi (317618), Anna Maria Brunati (317620), Livio Trentin (317624), Gianpietro Semenzato (287054), Renato Zambello (317614), Antonella Teramo (317603), Federica Frezzato (317597), Veronica Martini (317600), Elisa Ave (317609), Valentina Trimarco (317602), Monica Facco (8734), Samuela Carraro (317605), Cristina Gattazzo (317598)   +13 more
core   +1 more source

CryoBN‐PAGE: A Rapid and Cost‐Effective Method for the Analysis of Yeast Respiratory Complexes and Their Dynamic Organization

Yeast, EarlyView.
We present cryoBN‐PAGE, a method that enables blue native polyacrylamide gel electrophoresis analysis of mitochondrial respiratory complexes and supercomplexes directly from whole yeast cells using cryogenic milling. This approach eliminates the need for mitochondrial isolation, reducing time and cost while preserving native protein complexes.
Lizeth J. Camacho Lopez, Mazzen H. Eldeeb, Elliana G. Mohrhardt, Flavia Fontanesi   +3 more
wiley   +1 more source

Progressive Multifocal Leukoencephalopathy in B-CLL Successfully Treated With Venetoclax and Pembrolizumab. [PDF]

Hemasphere, 2022
Olivieri J, Lauzzana P, Volpetti S, Girgenti M, Petruzzellis G, Candoni A, Fanin R.   +6 more
europepmc   +1 more source