Results 71 to 80 of about 65,038 (202)

CD40 activation: potential for specific immunotherapy in B-CLL

Annals of Oncology, 2004
Despite encouraging scientific and therapeutic advances, chronic lymphocytic leukemia (CLL) principally remains an incurable disease. Allogeneic transplantation represents the only curative approach, but is marked by high mortality. Novel and less toxic treatment modalities are needed.
M, von Bergwelt-Baildon, B, Maecker, J, Schultze, J G, Gribben   +3 more
openaire   +2 more sources

Chronic Lymphocytic Leukemia: Insights from Lymph Nodes & Bone Marrow and Clinical Perspectives [PDF]

, 2010
B-cell chronic lymphocytic leukemia (B-CLL) is characterized by highly variable distribution of tumor mass between peripheral blood, bone marrow and lymphoid organs which is important for staging, classification and prognosis.
Branimir Jakšić, Ika Kardum-Skelin, Ozren Jakšić   +2 more
core   +1 more source

Extracellular vesicles of bone marrow stromal cells rescue chronic lymphocytic leukemia B cells from apoptosis, enhance their migration and induce gene expression modifications

Haematologica, 2017
Interactions between chronic lymphocytic leukemia (CLL) B cells and the bone marrow (BM) microenvironment play a major function in the physiopathology of CLL.
Emerence Crompot, Michael Van Damme, Karlien Pieters, Marjorie Vermeersch, David Perez-Morga, Philippe Mineur, Marie Maerevoet, Nathalie Meuleman, Dominique Bron, Laurence Lagneaux, Basile Stamatopoulos   +10 more
doaj   +1 more source

Molecular Cytogenetic Analysis of B-CLL Patients with Aggressive Disease

Hematology, 2004
We tested a set of commercially available probes to determine the feasibility and accuracy of FISH in the detection of abnormalities in 13 patients with Chronic Lymphocytic Leukemia (CLL) with a particular aggressive clinical disease. We utilized three different probes for the 13q12-14 region, one for the centromeric region of chromosome 12, one for ...
Gozzetti A., Crupi R., Tozzuoli D., Raspadori D., Forconi F., Lauria F.   +5 more
openaire   +5 more sources

B-1 derived anti-Thy-1 B cells in old aged mice develop lymphoma/leukemia with high expression of CD11b and Hamp2 that different from TCL1 transgenic mice

Immunity & Ageing
Human old aged unmutated chronic lymphocytic leukemia U-CLL are the TCL1+ZAP70+CD5+ B cells. Since CD5 makes the BCR signaling tolerance, ZAP70 increased in U-CLL not only TCL1+ alone. In mice, TCL1 (TCL1A) is the negative from neonate to old aged, as TC–
Kyoko Hayakawa, Yan Zhou, Susan A. Shinton   +2 more
doaj   +1 more source

B Cell Subsets and Immune Checkpoint Expression in Patients with Chronic Lymphocytic Leukemia

Current Issues in Molecular Biology
Chronic lymphocytic leukemia (CLL) is characterized by dysfunctional B cells. Immune checkpoint molecules such as cytotoxic T-lymphocyte-associated protein 4 (CTLA-4) and programmed death-1 (PD-1) are upregulated in patients with CLL and may correlate ...
Aviwe Ntsethe, Zekhethelo Alondwe Mkhwanazi, Phiwayinkosi Vusi Dludla, Bongani Brian Nkambule   +3 more
doaj   +1 more source

B-cell chronic lymphocytic leukemia-associated nuclear antigens [PDF]

, 2008
One- and two-dimensional polyacrylamide gel electrophoresis were used to compare the composition of nuclear polypeptides from normal and В-cell chronic lymphocytic leukemia mononuclear cells.
Błoński, Jerzy Z., Kiliańska, Zofia M., Robak, Tadeusz, Rogalinska, Malgorzata   +3 more
core  

Activated allogeneic NK cells preferentially kill poor prognosis B-cell chronic lymphocytic leukemia cells

Frontiers in Immunology, 2016
Mutational status of TP53 together with expression of wild type (wt) IGHV represents the most widely accepted biomarkers, establishing a very poor prognosis in B-cell chronic lymphocytic leukemia (B-CLL) patients.
Diego Sanchez-Martinez, Pilar Lanuza, Natalia Gomez, Aura Muntasell, Elisa Cisneros Leralta, Manuela Moraru, Gemma Azaceta, Alberto Anel, Luis Martínez-Lostao, Martin Villalba, Luis Palomera, Carlos Vilches, Jose A García Marco, Julian Pardo, Julian Pardo   +14 more
doaj   +1 more source

Progressive Multifocal Leukoencephalopathy in B-CLL Successfully Treated With Venetoclax and Pembrolizumab. [PDF]

Hemasphere, 2022
Olivieri J, Lauzzana P, Volpetti S, Girgenti M, Petruzzellis G, Candoni A, Fanin R.   +6 more
europepmc   +1 more source

High-throughput analysis of the T cell receptor gene repertoire in low-count monoclonal B cell lymphocytosis reveals a distinct profile from chronic lymphocytic leukemia

Haematologica, 2020
Andreas Agathangelidis, Chrysi Galigalidou, Lydia Scarfò, Theodoros Moysiadis, Alessandra Rovida, Elisavet Vlachonikola, Electra Sofou, Fotis Psomopoulos, Anna Vardi, Pamela Ranghetti, Alexandra Siorenta, Alex Galanis, Kostas Stamatopoulos, Anastasia Chatzidimitriou, Paolo Ghia   +14 more
doaj   +1 more source