International Journal of Hematology-Oncology and Stem Cell Research, 2020 Background: The present work aimed to investigate the expression of CD160/ CD200 in CLL and other mature B-cell neoplasms (MBN) and their use as an additional diagnostic tool for differentiating CLL from other MBN.
Wafaa Ahmed El- Neanaey +3 more
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Chronic lymphocytic leukemia: insights from lymph nodes & bone marrow and clinical perspectives [Kronična limfocitna leukemija: uvidi iz limfnog čvora i koštane srži i kliničke perspektive] [PDF]
, 2010 B-cell chronic lymphocytic leukemia (B-CLL) is characterized by highly variable distribution of tumor mass between peripheral blood, bone marrow and lymphoid organs which is important for staging, classification and prognosis.
Jakšić, Branimir +2 more
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The role of immunophenotyping in differential diagnosis of chronic lymphocytic leukemia [PDF]
Srpski Arhiv za Celokupno Lekarstvo, 2014 Introduction. Accurate diagnosis of chronic lymphocytic leukemia (CLL) acquires immunophenotyping by flow cytometry in order to facilitate differential diagnosis between CLL and other mature B-cell neoplasms (MBCN). Objective.
Dragović-Ivančević Tijana +6 more
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Overexpression of the p73 gene is a novel finding in high-risk B-cell chronic lymphocytic leukemia [PDF]
, 2017 The p73 protein shares structural and functional similarities with the tumour-suppressor p53, but its role in neoplastic transformation is unknown. Alternative splicing leads to the expression of at least nine p73 C-terminal mRNA splice variants (α β γ δ
Aebi, S. +11 more
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Cell Reports, 2013 There is increasing interest in the chronic lymphocytic leukemia (CLL) microenvironment and the mechanisms that may promote CLL cell survival and proliferation.
Audun Os +8 more
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Chronic lymphocytic leukaemia: Up-dated recommendations on diagnosis and treatment [PDF]
, 2004 Diagnosis and treatment of chronic lymphatic leukaemia (CLL) are currently undergoing great change. New knowledge of prognosis factors and the numerous new therapeutic procedures now available, such as purine analogues, high-dose treatment and monoclonal
Bergmann, M., Emmerich, B., Hallek, M.
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Global distribution of DNA hydroxymethylation and DNA methylation in chronic lymphocytic leukemia
Epigenetics & Chromatin, 2019 Background Chronic lymphocytic leukemia (CLL) has been a good model system to understand the functional role of 5-methylcytosine (5-mC) in cancer progression.
Sara Wernig-Zorc +7 more
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PLoS Medicine, 2015 BackgroundChronic lymphocytic leukemia (CLL), the most common adulthood leukemia, is characterized by the accumulation of abnormal CD5+ B lymphocytes, which results in a progressive failure of the immune system.
Ana-Carolina Martinez-Torres +17 more
doaj +1 more source
Signaling capacity of FcγRII isoforms in B-CLL cells
Leukemia Research, 2005 Two main isoforms of Fcgamma receptor II (CD 32) have been described in humans: activatory FcgammaRIIA and inhibitory FcgammaRIIB. We have previously reported that B cells from a subset of chronic lymphocytic leukemia (B-CLL) patients express not only FcgammaRIIB, as normal B lymphocytes, but also the myeloid FcgammaRIIA.
Gamberale, Romina +6 more
openaire +3 more sources
Inhibition of NF-κB-mediated signaling by the cyclin-dependent kinase inhibitor CR8 overcomes pro-survival stimuli to induce apoptosis in chronic lymphocytic leukemia cells [PDF]
, 2013 Purpose: Chronic lymphocytic leukemia (CLL) is currently incurable with standard chemotherapeutic agents, highlighting the need for novel therapies. Overcoming proliferative and cytoprotective signals generated within the microenvironment of lymphoid ...
Alison M. McCaig +14 more
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