Results 41 to 50 of about 65,038 (202)

Cytotoxic lymphocytes in B-cell chronic lymphocytic leukemia [PDF]

, 1990
The occurrence of cytotoxic lymphocyte subpopulations (i.e., CD 16+, CD57+ and cytotoxic CD 8+) was studied in the peripheral blood of 18 B-cell chronic lymphocytic leukemia (B-CLL) patients.
A Mittellman, A Verlardi, AC Bloem, B. G. Grooth, CD Platsoucas, CD Platsoucas, D Catovsky, F Hermann, F Lauria, F Lauria, GM Markey, HW Ziegler, I. Segers-Nolten, J. Greve, JA Wolos, KHG Mills, L. W. M. M. Terstappen, LWMM Terstappen, LWMM Terstappen, LWMM Terstappen, LWMM Terstappen, MA Mon de, N Chiorazzi, NE Kay, R Foa, R Foa, S Davis, T Han, T Inoshita, VP Hokland   +29 more
core   +3 more sources

TLR9 ligand (CpG oligodeoxynucleotide) induces CLL B-cells to differentiate into CD20+ antibody-secreting cells

Frontiers in Immunology, 2014
B-cell chronic lymphocytic leukemia (CLL) is the most frequent adult leukemia in the Western world. It is a heterogeneous disease characterized by clonal proliferation and the accumulation of CD5+ mature B lymphocytes.
Hussein eGhamlouch, Hussein eGhamlouch, Hakim eOuled-Haddou, Aude eGuyart, Aline eRegnier, Aline eRegnier, Stéphanie eTrudel, Stéphanie eTrudel, Jean-Francois eClaisse, Vincent eFuentes, Bruno eRoyer, Bruno eRoyer, Jean-Pierre eMarolleau, Jean-Pierre eMarolleau, Brigitte eGubler, Brigitte eGubler   +15 more
doaj   +1 more source

FISH Analysis for del6q21 and del17p13 in B-cell Chronic Lymphocytic Leukemia in Iranians [PDF]

, 2013
Background: B-cell chronic lymphocytic leukemia (B-CLL) is the most common leukemia in the Western world. Major progress has been made in assessing typical chromosomal abnormalities and recognition of the correlation of these chromosomal abnormalities ...
Akbari, Mohamad Taghi., Ashoori, Saeede., Hashemzadeh-Chaleshtori, Morteza., Mojtabavi Naeini, Marjan., Teimori, Hossein.   +4 more
core   +1 more source

Tracing CLL-biased stereotyped immunoglobulin gene rearrangements in normal B cell subsets using a high-throughput immunogenetic approach

Molecular Medicine, 2020
Background B cell receptor Immunoglobulin (BcR IG) repertoire of Chronic Lymphocytic Leukemia (CLL) is characterized by the expression of quasi-identical BcR IG.
Monica Colombo, Davide Bagnara, Daniele Reverberi, Serena Matis, Martina Cardillo, Rosanna Massara, Luca Mastracci, Jean Louis Ravetti, Luca Agnelli, Antonino Neri, Michela Mazzocco, Margherita Squillario, Andrea Nicola Mazzarello, Giovanna Cutrona, Andreas Agathangelidis, Kostas Stamatopoulos, Manlio Ferrarini, Franco Fais   +17 more
doaj   +1 more source

Distinct IRAK4 Expression in Normal and B-CLL Lymphocytes [PDF]

Journal of Cytology & Histology, 2014
Toll-like receptors (TLR) signaling plays an important role in the B cell biology. It induces the maturation, proliferation and antibody production in response to pathogen recognition. Interleukin-1 Receptor-associated Kinase-4 (IRAK-4) is TLR downstream molecule which is of strategic importance in starting a cascade of NF-kappaB (Nuclear factor-kappaB)
Sajewicz, Joanna, Choroszyńska, Dorota, Jargiełło-Baszak, Małgorzata   +2 more
openaire   +1 more source

Immunophenotypic characterization of the leukemic B-cells from Iranian patients with chronic lymphocytic leukemia : association between CD38 expression and disease progression [PDF]

, 2013
Background: Patients with B-cell chronic lymphocytic leukemia (B-CLL) have hetero-geneous clinical courses, thus several biological parameters need to be added to the cur-rent clinical staging systems to predict disease outcome.
Hojjat-Farsangi, Mohammad, Jeddi-Tehrani, Mahmood, Rabbani, Hodjatallah, Razavi, Seyed Mohsen, Shamsian Khoramabadi, Ahmad, Sharifian, Ramazan Ali, Shokri, Fazel   +6 more
core   +3 more sources

Differentiation of chronic lymphocytic leukemia B cells into immunoglobulin secreting cells decreases LEF-1 expression. [PDF]

PLoS ONE, 2011
Lymphocyte enhancer binding factor 1 (LEF-1) plays a crucial role in B lineage development and is only expressed in B cell precursors as B cell differentiation into mature B and plasma cells silences its expression.
Albert Gutierrez, Bonnie K Arendt, Renee C Tschumper, Neil E Kay, Clive S Zent, Diane F Jelinek   +5 more
doaj   +1 more source

Genome-wide DNA methylation profiling in chronic lymphocytic leukaemia

Frontiers in Genetics, 2023
Background: DNA methylation aberrations are widespread among the malignant B lymphocytes of patients with chronic lymphocytic leukaemia (CLL), suggesting that DNA methylation might contribute to the pathogenesis of CLL.Aim: We aimed to explore the ...
Qiuyi Zhang, Ying Gao, Ying Gao, Shuchun Lin, Lynn R. Goldin, Yonghong Wang, Holly Stevenson, Daniel C. Edelman, Keith Killian, Gerald Marti, Paul S. Meltzer, Song Xiang, Neil E. Caporaso   +12 more
doaj   +1 more source

Tailoring CD19xCD3-DART exposure enhances T-cells to eradication of B-cell neoplasms. [PDF]

, 2018
Many patients with B-cell malignancies can be successfully treated, although tumor eradication is rarely achieved. T-cell-directed killing of tumor cells using engineered T-cells or bispecific antibodies is a promising approach for the treatment of ...
Aliberti S, Bareja R, Bonvini E, Bruna R, Brusa D, Chiaretti S, Chichili GR, Cignetti A, Circosta P, Deaglio S, Elemento O, Elia AR, Foà R, Giacomo FD, Gottardi D, Guarini AR, Inghirami G., Johnson S, Kyriakides PW, Landra I, Machiorlatti R, Massaia M, Monteleone E, Moore PA, Todaro M   +24 more
core   +1 more source

Generation of Functional CLL-Specific Cord Blood CTL Using CD40-Ligated CLL APC [PDF]

, 2012
PMCID: PMC3526610This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are ...
A Trojan, AD Hamblin, AG Ramsay, AG Ramsay, AM Krackhardt, AP Kater, AP Kater, BL McClune, C Haller, C Mayr, C Nabhan, CA Rodrigues, D Bagnara, D Dilloo, D Wolf, D Xing, DA Mavroudis, DL Porter, Dongxia Xing, Elizabeth J. Shpall, Hiroshi Shiku, Hong Yang, I Ben-Bassat, I Hus, IF Khouri, J Chen, Jeffrey J. Molldrem, JG Gribben, JG Gribben, JM Rudolph, John G. Gribben, JS Miller, K Kato, M Hoogendorn, M Ritgen, MA King, Matthew M. Halpert, MF Bachmann, Michael J. Keating, N Shah, Nina Shah, R Le Dieu, R Mous, Ruth Lapushin, S Miscia, S Parmar, S Samarasinghe, Simon N. Robinson, Simrit Parmar, SL Martins, SM Schmidt, Sufang Li, T Nishida, WG Wierda, William G. Wierda, William K. Decker, WK Decker   +56 more
core   +5 more sources