AT514, a cyclic depsipeptide from Serratia marcescens, induces apoptosis of B-chronic lymphocytic leukemia cells. Interference with the Akt/NF-kB survival pathway [PDF]
, 2005 8 páginas, 5 figuras -- PAGS nros. 572-579Clinical treatment of B-cell chronic lymphocytic leukemia (B-CLL) is limited by the progressive drug resistance and nonselectivity of most drugs towards malignant cells.
Escobar-Díaz, Elisabeth +9 more
core +1 more source
ZAP70 Expression Within del6q21, del11q13 and del17p13 Cytogenetic Subgroups of Iranian Patients with Chronic Lymphocytic Leukemia [PDF]
, 2014 Background: B-cell chronic lymphocytic leukemia (B-CLL) is the most common form of leukemia in adults. Some reports showed that expression of ZAP70 gene and chromosomal abnormality are two prognostic factors in management of B-CLL Objectives: In this ...
Akbari, mohammad taghi. +5 more
core +1 more source
B Cell Chronic Lymphocytic Leukemia - A Model with Immune Response [PDF]
, 2013 B cell chronic lymphocytic leukemia (B-CLL) is known to have substantial clinical heterogeneity. There is no cure, but treatments allow for disease management.
de Pillis, Lisette G +2 more
core +3 more sources
The effects of splenic irradiation on lymphocyte subpopulations in chronic B-lymphocytic leukemia [PDF]
, 1988 We describe the effect of splenic irradiation (SI) (0,5–1 Gy weekly) on lymphocyte subpopulations for 7 patients with progressive B chronic B-lymphocytic leukemia (B-CLL).
Aabo +24 more
core +3 more sources
Cytomegalovirus infection does not impact on survival or time to first treatment in patients with chronic lymphocytic leukemia [PDF]
, 2016 Human cytomegalovirus (HCMV) is a widely prevalent herpes virus which establishes a state of chronic infection. The establishment of CMV‐specific immunity controls viral reactivation and leads to the accumulation of very large numbers of virus‐specific T
Adami +38 more
core +4 more sources
The isopeptidase inhibitor 2cPE triggers proteotoxic stress and ATM activation in chronic lymphocytic leukemia cells [PDF]
, 2016 Relapse after treatment is a common and unresolved problem for patients suffering of the B-cell chronic lymphocytic leukemia (B-CLL). Here we investigated the ability of the isopeptidase inhibitor 2cPE to trigger apoptosis in leukemia cells in comparison
Benedetti, Fabio +12 more
core +9 more sources
Frontiers in Immunology, 2022 Chronic lymphocytic leukemia (CLL), the most common adult’s leukemia in the western world, is caused in 95% of the cases by uncontrolled proliferation of monoclonal B-lymphocytes.
Regina Michelis +15 more
doaj +1 more source
Frontiers in Oncology, 2022 Chronic Lymphocytic Leukemia (CLL) is characterized by the progressive accumulation of monoclonal mature B lymphocytes. Autoimmune complications are common in CLL occurring in up to a quarter of all patients during the course of the illness.
Thibault Andrieu +9 more
doaj +1 more source
Matrix metalloproteinase-9 is up-regulated by CCL21/CCR7 interaction via extracellular signal-regulated kinase-1/2 signaling and is involved in CCL21-driven B-cell chronic lymphocytic leukemia cell invasion and migration [PDF]
, 2007 4 páginas, 2 figuras -- PAGS nros. 383-386B-cell chronic lymphocytic leukemia (B-CLL) progression is frequently accompanied by clinical lymphadenopathy, and the CCL21 chemokine may play an important role in this process. Indeed, CCR7 (the CCL21 receptor),
Javier Redondo-Muñoz +9 more
core +1 more source
Cellular Physiology and Biochemistry, 2015 Background/Aims: Pharmacological inhibition of the potassium channel Kv1.3 has been shown to selectively kill B cells from patients with chronic lymphocytic leukemia (B-CLL).
Ildiko Szabo +4 more
doaj +1 more source