Results 1 to 10 of about 65,038 (202)

Advocating the need of a systems biology approach for personalised prognosis and treatment of B-CLL patients [PDF]

BioDiscovery, 2012
The clinical course of B-CLL is heterogeneous. This heterogeneity leads to a clinical dilemma: can we identify those patients who will benefit from early treatment and predict the survival?
Hemanth Tummala, Alexey Goltsov, Hilal S Khalil, Anne Sproul, Fiona Scott, Vanio Mitev, Nikolai Zhelev   +6 more
doaj   +8 more sources

Epigenetics in B-CLL [PDF]

International Journal of Genomics
B-cell chronic lymphocytic leukemia (B-CLL) is the most common hematological malignancy in adults. Its clinical course is heterogeneous, ranging from indolent forms with slow progression to aggressive variants refractory to conventional treatment.
Alexandra Chu, Flavia Soto, Rodrigo Hurtado, Carlos A. Tirado   +3 more
doaj   +2 more sources

Upregulation of CD1d and ULBP3 on B cells from healthy donors and chronic lymphocytic leukaemia patients does not prime them for killing by γδ T cells. [PDF]

PLoS ONE
Despite advances in treatment, chronic lymphocytic leukaemia (CLL) remains an incurable disease. Vδ1+ γδ T cells are reported to expand in CLL patients and to kill leukemic cells, placing them as candidates for immunotherapy.
Julie David, Amy Walsh, Ke Sin Seow, Ellen Walsh, Stefan Elekes, Rohit Upadhyay, Nawal A B Taher, Samiha Al Siyabi, Ashanty M Melo, Carmel Waldron, Elisabeth Vandenberghe, Anthony M McElligott, Derek G Doherty   +12 more
doaj   +2 more sources

CLL stereotyped B-cell receptor immunoglobulin sequences are recurrent in the B-cell repertoire of healthy individuals: Apparent lack of central and early peripheral tolerance censoring

Frontiers in Oncology, 2023
IntroductionThe leukemic cells of patients with chronic lymphocytic leukemia (CLL) are often unique, expressing remarkably similar IGHV-IGHD-IGHJ gene rearrangements, “stereotyped BCRs”.
Stefano Vergani, Davide Bagnara, Andreas Agathangelidis, Andreas Agathangelidis, Anita Kar Yun Ng, Gerardo Ferrer, Andrea N. Mazzarello, Florencia Palacios, Sophia Yancopoulos, Xiao-Jie Yan, Jaqueline C. Barrientos, Kanti R. Rai, Kostas Stamatopoulos, Nicholas Chiorazzi   +13 more
doaj   +1 more source

Autonomous B-cell receptor signaling and genetic aberrations in chronic lymphocytic leukemia-phenotype monoclonal B lymphocytosis in siblings of patients with chronic lymphocytic leukemia

Haematologica, 2023
Clonal expansion of CD5-expressing B cells, commonly designated as monoclonal B lymphocytosis (MBL), is a precursor condition for chronic lymphocytic leukemia (CLL).
Edwin Quinten, Julieta H. Sepúlveda-Yáñez, Marvyn T. Koning, Janneke A. Eken, Dietmar Pfeifer, Valeri Nteleah, Ruben A.L. de Groen, Diego Alvarez Saravia, Jeroen Knijnenburg, Hedwig E. Stuivenberg-Bleijswijk, Milena Pantic, Andreas Agathangelidis, Andrea Keppler-Hafkemeyer, Cornelis A. M. van Bergen, Roberto Uribe-Paredes, Kostas Stamatopoulos, Joost S.P. Vermaat, Katja Zirlik, Marcelo A. Navarrete, Hassan Jumaa, Hendrik Veelken   +20 more
doaj   +1 more source

Characterizing Features of Human Circulating B Cells Carrying CLL-Like Stereotyped Immunoglobulin Rearrangements

Frontiers in Oncology, 2022
Chronic Lymphocytic Leukemia (CLL) is characterized by the accumulation of monoclonal CD5+ B cells with low surface immunoglobulins (IG). About 40% of CLL clones utilize quasi-identical B cell receptors, defined as stereotyped BCR.
Davide Bagnara, Monica Colombo, Daniele Reverberi, Serena Matis, Rosanna Massara, Niccolò Cardente, Gianluca Ubezio, Vanessa Agostini, Luca Agnelli, Luca Agnelli, Antonino Neri, Martina Cardillo, Stefano Vergani, Fabio Ghiotto, Fabio Ghiotto, Andrea Nicola Mazzarello, Fortunato Morabito, Fortunato Morabito, Giovanna Cutrona, Manlio Ferrarini, Franco Fais, Franco Fais   +21 more
doaj   +1 more source

B-cell antigen receptor expression and phosphatidylinositol 3-kinase signaling regulate genesis and maintenance of mouse chronic lymphocytic leukemia

Haematologica, 2022
Chronic lymphocytic leukemia (CLL) is a frequent lymphoproliferative disorder of B cells. Although inhibitors targeting signal proteins involved in B-cell antigen receptor (BCR) signaling constitute an important part of the current therapeutic protocols
Vera Kristin Schmid, Ahmad Khadour, Nabil Ahmed, Carolin Brandl, Lars Nitschke, Klaus Rajewsky, Hassan Jumaa, Elias Hobeika   +7 more
doaj   +1 more source

MicroRNA expression profiling identifies activated B cell status in chronic lymphocytic leukemia cells. [PDF]

PLoS ONE, 2011
Chronic lymphocytic leukemia (CLL) is thought to be a disease of resting lymphocytes. However, recent data suggest that CLL cells may more closely resemble activated B cells.
Shuqiang Li, Howell F Moffett, Jun Lu, Lillian Werner, Hao Zhang, Jerome Ritz, Donna Neuberg, Kai W Wucherpfennig, Jennifer R Brown, Carl D Novina   +9 more
doaj   +1 more source

B-CLL cells with unusual properties [PDF]

International Journal of Cancer, 1997
In studies concerning the interaction of B-CLL cells and Epstein-Barr virus (EBV), we encountered one patient whose cells had several unusual properties. In addition to the B-cell markers, the CLL cells expressed the exclusive T-cell markers CD3 and CD8 and carried a translocation t(18,22)(q21;q11), involving the bcl-2 and Ig lambda loci.
J, Avila-Cariño, N, Lewin, Y, Tomita, A, Szeles, A, Sandlund, S, Mosolits, H, Mellstedt, G, Klein, E, Klein   +8 more
openaire   +2 more sources

IGHV1-69 B cell chronic lymphocytic leukemia antibodies cross-react with HIV-1 and hepatitis C virus antigens as well as intestinal commensal bacteria. [PDF]

PLoS ONE, 2014
B-cell chronic lymphocytic leukemia (B-CLL) patients expressing unmutated immunoglobulin heavy variable regions (IGHVs) use the IGHV1-69 B cell receptor (BCR) in 25% of cases.
Kwan-Ki Hwang, Ashley M Trama, Daniel M Kozink, Xi Chen, Kevin Wiehe, Abby J Cooper, Shi-Mao Xia, Minyue Wang, Dawn J Marshall, John Whitesides, Munir Alam, Georgia D Tomaras, Steven L Allen, Kanti R Rai, Jane McKeating, Rosa Catera, Xiao-Jie Yan, Charles C Chu, Garnett Kelsoe, Hua-Xin Liao, Nicholas Chiorazzi, Barton F Haynes   +21 more
doaj   +1 more source