Results 1 to 10 of about 12,336,620 (246)
International Journal of GenomicsB-cell chronic lymphocytic leukemia (B-CLL) is the most common hematological malignancy in adults. Its clinical course is heterogeneous, ranging from indolent forms with slow progression to aggressive variants refractory to conventional treatment.
Alexandra Chu +3 more
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Frontiers in Oncology, 2023 IntroductionThe leukemic cells of patients with chronic lymphocytic leukemia (CLL) are often unique, expressing remarkably similar IGHV-IGHD-IGHJ gene rearrangements, “stereotyped BCRs”.
Stefano Vergani +13 more
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Frontiers in Oncology, 2022 Chronic Lymphocytic Leukemia (CLL) is characterized by the accumulation of monoclonal CD5+ B cells with low surface immunoglobulins (IG). About 40% of CLL clones utilize quasi-identical B cell receptors, defined as stereotyped BCR.
Davide Bagnara +21 more
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Haematologica, 2023 Clonal expansion of CD5-expressing B cells, commonly designated as monoclonal B lymphocytosis (MBL), is a precursor condition for chronic lymphocytic leukemia (CLL).
Edwin Quinten +20 more
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Haematologica, 2022 Chronic lymphocytic leukemia (CLL) is a frequent lymphoproliferative disorder of B cells. Although inhibitors targeting signal proteins involved in B-cell antigen receptor (BCR) signaling constitute an important part of the current therapeutic protocols
Vera Kristin Schmid +7 more
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MicroRNA expression profiling identifies activated B cell status in chronic lymphocytic leukemia cells. [PDF]
PLoS ONE, 2011 Chronic lymphocytic leukemia (CLL) is thought to be a disease of resting lymphocytes. However, recent data suggest that CLL cells may more closely resemble activated B cells.
Shuqiang Li +9 more
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IGHV1-69 B cell chronic lymphocytic leukemia antibodies cross-react with HIV-1 and hepatitis C virus antigens as well as intestinal commensal bacteria. [PDF]
PLoS ONE, 2014 B-cell chronic lymphocytic leukemia (B-CLL) patients expressing unmutated immunoglobulin heavy variable regions (IGHVs) use the IGHV1-69 B cell receptor (BCR) in 25% of cases.
Kwan-Ki Hwang +21 more
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Haematologica, 2023 Chronic lymphocytic leukemia (CLL) is an incurable indolent non-Hodgkin lymphoma characterized by tumor B cells that weakly express a B-cell receptor. The mutational status of the variable region (IGHV) within the immunoglobulin heavy chain (IGH) locus ...
Israa Al Jamal +19 more
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A combination of cytokines rescues highly purified leukemic CLL B-cells from spontaneous apoptosis in vitro. [PDF]
PLoS ONE, 2013 B-chronic lymphocytic leukemia (B-CLL), the most common human leukemia, is characterized by predominantly non-dividing malignant mature CD5+ B lymphocytes with an apoptosis defect.
Hussein Ghamlouch +5 more
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Frontiers in Oncology, 2021 The HCDR3 sequences of the B-cell receptor (BCR) undergo constraints in length, amino acid use, and charge during maturation of B-cell precursors and after antigen encounter, leading to BCR and antibodies with high affinity to specific antigens.
Arancha Rodríguez-Caballero +31 more
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