Results 31 to 40 of about 12,336,620 (246)

Expansion of CD4+ T cells with a cytotoxic phenotype in patients with B-chronic lymphocytic leukaemia (B-CLL)

, 2001
Abnormal CD4/CD8 ratios and T-cell function have previously been shown in patients with B-chronic lymphocytic leukaemia (B-CLL). We have demonstrated that CD4+ T cells containing both serine esterase and perforin (PF) are increased in the blood of these ...
Roschupkina, T., Patterson, K., Jewell, A.P., Yong, K., Yong, K.L., Lydyard, P.M., Porakishvili, N., Kalber, T.   +7 more
core   +1 more source

Chronobiology of Cancer: How Aging Fuels Oncogenesis at the Molecular Level

Aging and Cancer, EarlyView.
This graphical abstract illustrates the key biological pathways linking aging with cancer development and progression. In the upper left, cumulative exposure to ultraviolet radiation, toxins, and reactive oxygen species (ROS) causes DNA damage and genomic instability, whereas age‐related decline in repair mechanisms, such as ATM/ATR, BER, and NER ...
Anu Singh, Aroonima Misra, Sufian Zaheer
wiley   +1 more source

Anisotropic Memristive Switching in NbOCl2 Enabled by Directional Oxygen Ion Migration

Advanced Science, EarlyView.
This study investigates strongly orientation‐dependent memristive switching in anisotropic NbOCl2, observed exclusively along the in‐plane c‐axis. The switching originates from direction‐selective oxygen‐ion migration and vacancy propagation that modulate the Pd/NbOCl2 Schottky barrier, enabling short‐term plasticity.
Caokun Wang, Yun Ji, Sanchali Mitra, Yufei Shi, Haofei Zheng, Yee Sin Ang, Kah‐Wee Ang   +6 more
wiley   +1 more source

Continuous DNA methylation deconvolution-based surrogate for B-cell differentiation state in chronic lymphocytic leukemia

Communications Medicine
Background Chronic lymphocytic leukemia (CLL) is clinically divided categorically into IGHV mutated (M-CLL) and IGHV unmutated (U-CLL) subtypes. We aimed to generate a continuous metric of CLL epigenetic state to correspond to the many steps of B-cell ...
Jeffrey Hage, Lauren Wainman, Fiyinfoluwa Kolawole, Fred Kolling IV, Pauline Patzke, Daniel Schoolcraft, Sarah Spracklin, Prabhjot Kaur, Brock Christensen   +8 more
doaj   +1 more source

Potential therapeutic application of gold nanoparticles in B-chronic lymphocytic leukemia (BCLL): enhancing apoptosis

Journal of Nanobiotechnology, 2007
B-Chronic Lymphocytic Leukemia (CLL) is an incurable disease predominantly characterized by apoptosis resistance. We have previously described a VEGF signaling pathway that generates apoptosis resistance in CLL B cells.
Lu Lichun, Wang Shanfeng, Patra Chitta, Lee Yean K, Bone Nancy, Bhattacharya Resham, Mukherjee Priyabrata, Secreto Charla, Banerjee Pataki C, Yaszemski Michael J, Kay Neil E, Mukhopadhyay Debabrata   +11 more
doaj   +1 more source

germline gene-based B-CLL

, 2016
In 10-20% of the cases of chronic lymphocytic leukemia of B-cell phenotype (B-CLL), the IGHV1-69 germline is utilized as VH gene of the B cell receptor (BCR).
Wang, Xueqian, Peterson, Eric, Zhu, Quan, Fernandes, Stacey, Brown, Jennifer R, Jennifer R. Brown, Xueqian Wang, Aimee Tallarico, Roy Jefferis, Tallarico, Aimee, Kurella, Vinodh B, Yuval Avnir, Goodall, Margaret, Wang, Yanyan, Subhabrata Biswas, Stacey Fernandes, Margaret Goodall, Chang, De-Kuan, Quan Zhu, De-Kuan Chang, Wayne A Marasco, Eric Peterson, Sun, Jiusong, Jefferis, Roy, Yanyan Wang, Biswas, Subhabrata, Sui, Jianhua, Avnir, Yuval, Vinodh B. Kurella, Jianhua Sui, Panditrao, Madhura, Marasco, Wayne A, Jiusong Sun, Madhura Panditrao   +33 more
core   +1 more source

Cancer‐Associated BCL‐2 Mutants Reveal Mechanisms Towards Venetoclax Resistance

Advanced Science, EarlyView.
Venetoclax (VEN) resistance in chronic lymphocytic leukemia arises from diverse BCL2 mutations. We map mechanisms contributing to VEN resistance across common BCL‐2 variants. G101V and D103Y reduce drug binding and increase sequestration of pro‐apoptotic proteins. V156D blocks VEN allosterically.
Jonas Aufdermauer, Ian de Ridder, Mahjoobeh Ehsani, Marasim Khan, Justin Kale, Lukas P. Frenzel, David Andrews, Spyridoula Karamanou, Ana J. Garcia‐Saez, Geert Bultynck   +9 more
wiley   +1 more source

Optimized Cas9‐Enriched Nanopore Sequencing and Analysis Workflow for Clinical Diagnosis of Repeat Expansion Disorders

Advanced Science, EarlyView.
An optimized Cas9‐enriched nanopore sequencing workflow, combined with STRiker, enables simultaneous analysis of disease‐associated STR loci from patient blood. The nCATS–STRiker workflow detects repeat expansions, de novo repeat motifs, interruption patterns, and methylation in a single assay, improving the genetic diagnosis of previously undiagnosed ...
Seungbok Lee, Chanju Jung, Minjeong Kim, Narae Kim, Gue‐Ho Hwang, Soon‐Tae Lee, Kon Chu, Sang Kun Lee, Han‐Joon Kim, Jong‐Hee Chae, Sangsu Bae, Jangsup Moon   +11 more
wiley   +1 more source

TLR9 ligand (CpG oligodeoxynucleotide) induces CLL B-cells to differentiate into CD20+ antibody-secreting cells

Frontiers in Immunology, 2014
B-cell chronic lymphocytic leukemia (CLL) is the most frequent adult leukemia in the Western world. It is a heterogeneous disease characterized by clonal proliferation and the accumulation of CD5+ mature B lymphocytes.
Hussein eGhamlouch, Hussein eGhamlouch, Hakim eOuled-Haddou, Aude eGuyart, Aline eRegnier, Aline eRegnier, Stéphanie eTrudel, Stéphanie eTrudel, Jean-Francois eClaisse, Vincent eFuentes, Bruno eRoyer, Bruno eRoyer, Jean-Pierre eMarolleau, Jean-Pierre eMarolleau, Brigitte eGubler, Brigitte eGubler   +15 more
doaj   +1 more source

Study of immunophenotypic markers and clinico-hematological findings in chronic lymphocytic leukemia

Zanco Journal of Medical Sciences, 2023
Background and objective: Chronic lymphocytic leukemia (CLL) is a clonal, mature B-cell neoplasm, its clinical features, cell morphology, and immunophenotyping are used to establish the diagnosis.
Ansam Mazin Butrous, Newsherwan Sadiq Muhammad   +1 more
doaj   +1 more source