Results 91 to 100 of about 36,982 (261)

Convex contractions on extended $ b $-metric spaces

open access: yesAIMS Mathematics
<abstract><p>This research investigated different types of convex contractions in the setting of extended $ b $-metric spaces from the point of view of the existence and uniqueness of their fixed points. The assumptions imposed on involved mappings refer to convexity of order $ 2 $, two-sided convexity or Ćirić-type convexity, which also ...
openaire   +2 more sources

Discerning protein pools by selective staining with self‐labeling tags

open access: yesFEBS Letters, EarlyView.
Cell surface proteins have an intra‐ and extracellular pool. Combining genetic fusion to self‐labeling tags that can be addressed with small molecule fluorophores allows separating these pools. We highlight recent developments and techniques for state‐of‐the‐art interrogation of cell surface proteins in the complex tissue setting.
Kati Fischermanns, Johannes Broichhagen
wiley   +1 more source

On Topology of Fuzzy Strong b-Metric Spaces

open access: yesJournal of New Theory, 2018
In this study, we introduce and investigate the concept of fuzzy strong b-metric space such that is a fuzzy analogy of strong b-metric spaces. By using the open balls, we define a topology on these spaces which is Hausdor® and first countable. Later
Tarkan Oner
doaj  

Peripheral lysosomes recruit PLEKHG3 to focal adhesions and restrain protrusion dynamics

open access: yesFEBS Letters, EarlyView.
Proximity‐dependent labeling at the LAMTOR complex revealed the Rho GEF PLEKHG3 as a lysosome‐proximal protein directing the study toward the influence of lysosome positioning on actin dynamics and cell motility. We show that PLEKHG3 colocalizes with lysosomes at focal adhesion sites and observe that forced peripheral dispersion of lysosomes hinders ...
Rainer Ettelt   +8 more
wiley   +1 more source

Golgi enzymes are retrieved from the plasma membrane to the trans‐Golgi network

open access: yesFEBS Letters, EarlyView.
Golgi enzymes are traditionally considered resident proteins retained within the Golgi apparatus. Here, we demonstrate that a subset transiently reaches the cell surface and is subsequently retrieved to the trans‐Golgi network via retrograde transport. Using a nanobody‐based toolkit, we uncover a dynamic trafficking cycle of several Golgi enzymes.
Dominik P. Buser, Tina Junne
wiley   +1 more source

Generalization of Fixed Point Theorem for φ- Contraction Mapping of a Fuzzy b- Metric Space

open access: yesIbn Al-Haitham Journal for Pure and Applied Sciences
Let (X,W,T) be a fuzzy b- metric space, where X is a non-empty set, W is a fuzzy set on X×X×(0,∞) to [0,1], and T is a continuous t-norm, and let a function φ:[0,1]→[0,1] satisfies the following conditions: The function φ is strictly decreasing and ...
Russll Abdul Kadhim Mohammed   +1 more
doaj   +1 more source

Engineered extracellular vesicles enriched with the miR‐214/199a cluster enhance the efficacy of chemotherapy in ovarian cancer

open access: yesMolecular Oncology, EarlyView.
Loss of the miR‐214/199a cluster is associated with recurrence in ovarian cancer. Engineered small extracellular vesicles (m214‐sEVs) elevate miR‐214‐3p/miR‐199a‐5p in tumor cells, suppress β‐catenin, TLR4, and YKT6 signaling, reprogram tumor‐derived sEV cargo, reduce chemoresistance and migration, and enhance carboplatin efficacy and survival in ...
Weida Wang   +12 more
wiley   +1 more source

Establishment of a humanized patient‐derived xenograft mouse model of high‐grade serous ovarian cancer for preclinical evaluation of combination immunotherapy

open access: yesMolecular Oncology, EarlyView.
We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric   +10 more
wiley   +1 more source

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