Results 101 to 110 of about 104,464 (301)
CCDC80 suppresses high‐grade serous ovarian cancer migration via negative regulation of B7‐H3
Molecular Oncology, EarlyView.PAX8 is a lineage‐specific master regulator of transcription in high‐grade serous ovarian cancer (HGSC) progression. We show for the first time that PAX8 facilitates proliferation and metastasis by repressing the cell autonomous tumor suppressor CCDC80 and inducing B7‐H3 expression.
Aya Saleh +12 more
wiley +1 more source
Fractals in extended b-metric space.
, 2017 Iterated function systems are method of constructing fractals, which are based on the mathematical foundations laid by Hutchinson[1] and Barnsley[2]. Formally an Iterated function systems is a finite set of ‘contraction mappings’, on a complete metric space X.
Subashi, Ledia, Gjini, Nertila
openaire +1 more source
Molecular Oncology, EarlyView.We analyze cisplatin–DNA adducts (CDAs) and double‐strand breaks (DSBs) in a cell‐cycle‐dependent manner. We find that CDAs form similarly across all cell cycle phases. DSBs arise only in S‐phase. CDAs might not directly impair DSB repair, but S‐phase DSB lesions evolve in the presence of CDAs and disrupt repair in G2, also causing radiosensitization ...
Ye Qiu +10 more
wiley +1 more source
, 2019 The first two authors would like to thank TUBITAK (The Scientific and Technological Research Council of Turkey) for its financial support during their doctorate studies.
POŞUL, Hande +2 more
openaire +3 more sources
Condensing on metric spaces : modeling, analysis and simulation
, 2009 In this work, we extend the Hegselmann and Krause (HK) model, presented in [16] to an arbitrary metric space. We also present some theoretical analysis and some numerical results of the condensing of particles in finite and continuous metric spaces.
Zahri, Mostafa
core
, 2013 The main results of this paper show that various coarse (‘large scale’) geometric properties are closely related. In particular, we show that prop- erty A implies the operator norm localisation property, and thus that norms of operators associated to a ...
Wright, Nick +4 more
core +1 more source
Estimating the weight of metric minimum spanning trees in sublinear time [PDF]
, 2008 In this paper we present a sublinear-time $(1+\varepsilon)$-approximation randomized algorithm to estimate the weight of the minimum spanning tree of an $n$-point metric space. The running time of the algorithm is $\widetilde{\mathcal{O}}(n/\varepsilon^{\
Christian Sohler +3 more
core +1 more source
Molecular Oncology, EarlyView.Here, we demonstrate that HS1BP3 interacts with Cortactin through a proline‐rich region (PRR3.1) and show that this interaction, and HS1BP3 itself, promote cancer cell proliferation and invasion. Inhibition of this interaction leads to build‐up of TKS5 in multivesicular endosomes and altered secretion of CD63 and CD9, providing an explanation for the ...
Arja Arnesen Løchen +9 more
wiley +1 more source
Interpreting the effects of DNA polymerase variants at the structural level
Molecular Oncology, EarlyView.Using MAVISp and molecular dynamics simulations, we analyzed over 60 000 missense variants in POLE and POLD1 from ClinVar, COSMIC, cBioPortal, and saturation mutagenesis. Identified mechanistic indicators, including stability, binding, and long‐range, enable structural interpretation, providing ACMG‐like evidence for possible reclassification of VUS ...
Matteo Arnaudi +7 more
wiley +1 more source
Stone-type theorem on b-metric spaces and applications
Topology and its Applications, 2015 A triple \((X,d,k)\) is called a \(b\)-metric space if \(X\) is a non-empty set, \(k\geq 1\) is a constant, and \(d: X\times X\to[0,+\infty)\) is a function satisfying (1) \(d(x,y)= 0\) if and only if \(x=y\), (2) \(d(x,y)= d(y, x)\), and (3) \(d(x, z)\leq k[d(x,y)+ d(y, z)]\) for all \(x,y,z\in X\). For \(k=2\), \(b\)-metric spaces were introduced by \
Tran Van An +2 more
openaire +1 more source