Results 81 to 90 of about 36,982 (261)

Identification of a Shiga toxin A‐derived peptide internalized into Gb3 receptor‐bearing cells via interaction with the Shiga toxin B subunit

FEBS Letters, EarlyView.
The process of internalization of the Shiga toxin A subunit via formation of a complex with the Shiga toxin B subunit, which specifically binds to the Gb3 receptor. The peptide is designed to act as a carrier of drugs into cancer cells. Here, we explored the potential of peptides derived from the catalytic A subunit of Shiga toxin (STxA) to be drug ...
Giulia Opassi, João C. Encarnação, Valeria Napolitano, Grzegorz Dubin, Grzegorz Popowicz, Karl Andersson, U. Helena Danielson   +6 more
wiley   +1 more source

Stone-type theorem on b-metric spaces and applications

Topology and its Applications, 2015
A triple \((X,d,k)\) is called a \(b\)-metric space if \(X\) is a non-empty set, \(k\geq 1\) is a constant, and \(d: X\times X\to[0,+\infty)\) is a function satisfying (1) \(d(x,y)= 0\) if and only if \(x=y\), (2) \(d(x,y)= d(y, x)\), and (3) \(d(x, z)\leq k[d(x,y)+ d(y, z)]\) for all \(x,y,z\in X\). For \(k=2\), \(b\)-metric spaces were introduced by \
Tran Van An, Luong Quoc Tuyen, Nguyen Van Dung   +2 more
openaire   +1 more source

Investigating transcription factor dynamics in health and disease using FRAP

FEBS Letters, EarlyView.
FRAP analysis of GFP‐tagged transcription factors reveals how molecular mobility and target engagement change in response to drug treatment. By combining live‐cell imaging, quantitative model fitting, and statistical analysis, this approach uncovers transcription factor dynamics linked to disease mechanisms, providing a powerful framework for ...
Kannan Govindaraj, Carolina Vazquez Garzon, Jose Joaquin Velasco, Janine N. Post   +3 more
wiley   +1 more source

Fuzzy Cone B-Metric Spaces

, 2019
The first two authors would like to thank TUBITAK (The Scientific and Technological Research Council of Turkey) for its financial support during their doctorate studies.
POŞUL, Hande, KAPLAN, Elif, KÜTÜKCÜ, Servet   +2 more
openaire   +3 more sources

Conserved binding mode but diverse interfaces of MreC‐PBP2 interactions

FEBS Letters, EarlyView.
The crystal structure of abMreC reveals a conserved two β‐barrel architecture and provides structural insights into its role within the bacterial elongasome. The abMreC–abPBP2 complex model identifies the molecular basis of MreC‐mediated PBP2 recognition, contributing to the regulation of peptidoglycan synthesis.
Hyunseok Jang, Hyo Been Jin, Chang Min Kim, So Yeon Lee, Hyun Ho Park   +4 more
wiley   +1 more source

Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential

FEBS Letters, EarlyView.
Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta, Hari Baskar Balasubramanian, Amir Pasokh, Marietta Zille   +3 more
wiley   +1 more source

Various Suzuki type theorems in b -metric spaces

Journal of Nonlinear Sciences and Applications, 2015
Summary: In this paper, we prove some fixed point results for \(\alpha\)-admissible mappings which satisfy Suzuki type contractive condition in the setup of \(b\)-metric spaces. Finally, examples are presented to verify the effectiveness and applicability of our main results.
Latif, A., Parvaneh, V., Salimi, P., Al-Mazrooei, A. E.   +3 more
openaire   +3 more sources

Structure‐forward targeting of claudins with synthetic binders

FEBS Letters, EarlyView.
Claudins form the paracellular barriers between epithelial and endothelial tissues at tight junctions and are targets for molecular binders with the goal of modulating barrier permeability. Claudin‐binding molecules are relevant in drug delivery or in altering claudin interactions with disease‐causing proteins.
Alex J. Vecchio
wiley   +1 more source

Fixed Point and Common Fixed Point Theorems on Ordered Cone b-Metric Spaces

Abstract and Applied Analysis, 2013
The concept of a cone b-metric space has been introduced recently as a generalization of a b-metric space and a cone metric space in 2011. The aim of this paper is to establish some fixed point and common fixed point theorems on ordered cone b-metric ...
Sahar Mohammad Abusalim, Mohd Salmi Md Noorani   +1 more
doaj   +1 more source

On New Type of F-Contractive Mapping for Quasipartial b-Metric Spaces and Some Results of Fixed-Point Theorem and Application

Journal of Mathematics, 2020
In this paper, we introduce the concept of new type of F-contractive type for quasipartial b-metric spaces and some definitions and lemmas. Also, we will prove a new fixed-point theorem in quasipartial b-metric spaces for F-contractive type mappings.
A. M. Zidan, Asma Al Rwaily
doaj   +1 more source