Results 81 to 90 of about 104,464 (301)

TRAIL‐PEG‐Apt‐PLGA nanosystem as an aptamer‐targeted drug delivery system potential for triple‐negative breast cancer therapy using in vivo mouse model

Molecular Oncology, EarlyView.
Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat, Aslihan Kucuk, Omer Erdogan, Samed Ozer, Bensu Kozan, Tugba Cuceli, Erkan Gumus, Evrim Cevik, Ozge Cevik   +8 more
wiley   +1 more source

Some results in quasi-b-metric-like spaces [PDF]

Journal of Inequalities and Applications, 2014
Abstract In this paper, we introduce a new concept of quasi-b-metric-like spaces as a generalization of b-metric-like spaces and quasi-metric-like spaces. Some fixed point theorems are investigated in quasi-b-metric-like spaces. Moreover, an example is given to support one of our results. MSC:47H10, 54H25.
Zhu, Chuanxi, Chen, Chunfang, Zhang, Xiaozhi   +2 more
openaire   +2 more sources

Network divergence analysis identifies adaptive gene modules and two orthogonal vulnerability axes in pancreatic cancer

Molecular Oncology, EarlyView.
Tumors contain diverse cellular states whose behavior is shaped by context‐dependent gene coordination. By comparing gene–gene relationships across biological contexts, we identify adaptive transcriptional modules that reorganize into distinct vulnerability axes.
Brian Nelson, Lyanne Delgado‐Coka, Natalia Marchenko, Luisa F. Escobar‐Hoyos, Kenneth R. Shroyer, Alisa Yurovsky, Trey Ideker, Gábor Balázsi, Thomas MacCarthy, Scott Powers   +9 more
wiley   +1 more source

Multivalued Contraction Fixed-Point Theorem in b-Metric Spaces

Mathematics
The authors explore fixed-point theory in b-metric spaces and strong b-metric spaces. They wish to prove some new extensions of the Covitz and Nadler fixed-point theorem in b-metric spaces. In so doing, they wish to answer a question proposed by Kirk and
Bachir Slimani, John R. Graef, Abdelghani Ouahab   +2 more
doaj   +1 more source

Infinitary rewriting: meta-theory and convergence [PDF]

, 2007
When infinitary rewriting was introduced by Kaplan et.al. at the beginning of the 1990s, its term universe was explained as the metric completion of a metric on finite terms.
Kahrs, Stefan
core   +1 more source

EDNRB‐dependent endothelin signaling reduces proliferation and promotes proneural‐to‐mesenchymal transition in gliomas

Molecular Oncology, EarlyView.
Glioma cells mainly express the endothelin receptor EDNRB, while EDNRA is restricted to a perivascular tumor subpopulation. Endothelin signaling reduces glioma cell proliferation while promoting migration and a proneural‐to‐mesenchymal transition associated with poor prognosis. This pathway activates Ca2+, K+, ERK, and STAT3 signalings and is regulated
Donovan Pineau, Leonor Garcia, Hugo Arnold, Antonija Hanžek, Maialen Arrieta, Laurent R Gauthier, Christine Granotier‐Beckers, François D Boussin, Amaury Herbet, Marie Hautière, Valentin Asei‐Ceschino, Clémentin Jacques, Laura Brard, Thomas Harnois, Valérie Coronas, Bruno Constantin, Aurélien Chatelier, Jean Chemin, Serge Urbach, Martial Seveno, Szimonetta Hideg, Chantal Ripoll, Kasandra Aguilar‐Cázarez, Min Zheng, Guo‐Hao Huang, Sheng‐Qing Lv, Lei Zhang, Philippe Rondard, Laurent Prezeau, Jean‐Philippe Pin, Hugues Duffau, Luc Bauchet, Valérie Rigau, Franck Denat, Charles Truillet, Didier Boquet, Jean‐Philippe Hugnot   +36 more
wiley   +1 more source

Common Best Proximity Point Theorems for Generalized Proximal Weakly Contractive Mappings in b-Metric Space

Abstract and Applied Analysis, 2022
In this paper, common best proximity point theorems for weakly contractive mapping in b-metric spaces in the cases of nonself-mappings are proved; we introduced the notion of generalized proximal weakly contractive mappings in b-metric spaces and proved ...
Yohannes Gebru, Yitages Negede
doaj   +1 more source

Common fixed point theorems for cyclic contractive mappings in partial cone b-metric spaces and applications to integral equations

Nonlinear Analysis, 2016
In this paper, we introduce the concept of partial cone b-metric spaces as a generalization of partial metric, cone metric and b-metric spaces and establish some topological properties of partial cone b-metric spaces.
Chuanxi Zhu, Wenqing Xu, Tatjana Došenovič, Zorana Golubovic   +3 more
doaj   +1 more source

Configuration spaces of thick particles on graphs [PDF]

, 2011
In this thesis, we study the topology of configuration spaces of particles of variable radius r>0 moving on a metric graph. Our main tool is a piecewise linear (PL) Morse-Bott theory for affine polytope complexes, which extends the Morse theory for such ...
DEELEY, KENNETH
core  

Engineered extracellular vesicles enriched with the miR‐214/199a cluster enhance the efficacy of chemotherapy in ovarian cancer

Molecular Oncology, EarlyView.
Loss of the miR‐214/199a cluster is associated with recurrence in ovarian cancer. Engineered small extracellular vesicles (m214‐sEVs) elevate miR‐214‐3p/miR‐199a‐5p in tumor cells, suppress β‐catenin, TLR4, and YKT6 signaling, reprogram tumor‐derived sEV cargo, reduce chemoresistance and migration, and enhance carboplatin efficacy and survival in ...
Weida Wang, Ayesha Alvero, Yi Qin, Mingjin Wang, Alexandra Fox, Yanfeng Li, Michael Millman, Amy Kemper, Gil Mor, Xian Shuang Liu, Michael Chopp, Zheng Gang Zhang, Yi Zhang   +12 more
wiley   +1 more source