Results 191 to 200 of about 5,411,122 (304)

Phenotypic and genotypic characterization of single circulating tumor cells in the follow‐up of high‐grade serous ovarian cancer

Molecular Oncology, EarlyView.
Single circulating tumor cells (sCTCs) from high‐grade serous ovarian cancer patients were enriched, imaged, and genomically profiled using WGA and NGS at different time points during treatment. sCTCs revealed enrichment of alterations in Chromosomes 2, 7, and 12 as well as persistent or emerging oncogenic CNAs, supporting sCTC identity.
Carolin Salmon, Rui P. L. Neves, Nikolas H. Stoecklein, Sven‐Thorsten Liffers, Jens Siveke, Jan D. Kuhlmann, Pauline Wimberger, Paul Buderath, Rainer Kimmig, Sabine Kasimir‐Bauer   +9 more
wiley   +1 more source

Longitudinal multi-b-value diffusion-weighted imaging in renal transplant recipients: diagnostic efficacy and prognostic value for allograft dysfunction. [PDF]

Quant Imaging Med Surg
Chen L, Yang P, Cui J, Xie S, Lu Y, Sun D, Zhu J, Grimm R, Shen W.   +8 more
europepmc   +1 more source

Both noise-floor and tissue compartment difference in diffusivity contribute to FA dependence on b-value in diffusion MRI. [PDF]

Hum Brain Mapp, 2023
Yao J, Tendler BC, Zhou Z, Lei H, Zhang L, Bao A, Zhong J, Miller KL, He H.   +8 more
europepmc   +1 more source

Combining antibody conjugates with cytotoxic and immune‐stimulating payloads maximizes anti‐cancer activity

Molecular Oncology, EarlyView.
Methods to improve antibody–drug conjugate (ADC) treatment durability in cancer therapy are needed. We utilized ADCs and immune‐stimulating antibody conjugates (ISACs), which are made from two non‐competitive antibodies, to enhance the entry of toxic payloads into cancer cells and deliver immunostimulatory agents into immune cells.
Tiexin Wang, Dong Jun Koo, Peter M. Tessier, Greg M. Thurber   +3 more
wiley   +1 more source

Deep learning network enhances imaging quality of low-b-value diffusion-weighted imaging and improves lesion detection in prostate cancer. [PDF]

BMC Cancer
Liu Z, Gu WJ, Wan FN, Chen ZZ, Kong YY, Liu XH, Ye DW, Dai B.   +7 more
europepmc   +1 more source

A feasibility study of reduced full-of-view synthetic high-b-value diffusion-weighted imaging in uterine tumors. [PDF]

Insights Imaging, 2023
Tang Q, Zhou Q, Chen W, Sang L, Xing Y, Liu C, Wang K, Liu WV, Xu L.   +8 more
europepmc   +1 more source

Dammarenediol II enhances etoposide‐induced apoptosis by targeting O‐GlcNAc transferase and Akt/GSK3β/mTOR signaling in liver cancer

Molecular Oncology, EarlyView.
Etoposide induces DNA damage, activating p53‐dependent apoptosis via caspase‐3/7, which cleaves PARP1. Dammarenediol II enhances this apoptotic pathway by suppressing O‐GlcNAc transferase activity, further decreasing O‐GlcNAcylation. The reduction in O‐GlcNAc levels boosts p53‐driven apoptosis and influences the Akt/GSK3β/mTOR signaling pathway ...
Jaehoon Lee, Byung‐Cheol Han, Gi‐Bang Koo, Jihye Park, Mijin Kwon, Young Bin Park, Jae‐Mun Choi, Seung‐Ho Lee, Sangho Roh   +8 more
wiley   +1 more source

New lens on breast health: harnessing high-b-value synthetic diffusion-weighted imaging for breast lesion characterization. [PDF]

Diagn Interv Radiol
Karabiyik S, Ramadan S, Settarzade E, Filiz AI, Ozturkmen Akay H.   +4 more
europepmc   +1 more source

Tumor mutational burden as a determinant of metastatic dissemination patterns

Molecular Oncology, EarlyView.
This study performed a comprehensive analysis of genomic data to elucidate whether metastasis in certain organs share genetic characteristics regardless of cancer type. No robust mutational patterns were identified across different metastatic locations and cancer types.
Eduardo Candeal, Andrea Moreno‐Manuel, Miguel Salvadó‐Pertierra, Cristina Santos‐Vivas, Rebeca Sanz‐Pamplona   +4 more
wiley   +1 more source

<i>b</i>-Value Evaluation and Applications to Seismic Hazard Assessment. [PDF]

Entropy (Basel)
Chang Y, Wang R, Han P, Wang J, Miao M, Zeng Z, Wu W, Jiang C, Meng L, Shi H, Hattori K.   +10 more
europepmc   +1 more source