Results 201 to 210 of about 30,612,164 (294)

Dammarenediol II enhances etoposide‐induced apoptosis by targeting O‐GlcNAc transferase and Akt/GSK3β/mTOR signaling in liver cancer

Molecular Oncology, EarlyView.
Etoposide induces DNA damage, activating p53‐dependent apoptosis via caspase‐3/7, which cleaves PARP1. Dammarenediol II enhances this apoptotic pathway by suppressing O‐GlcNAc transferase activity, further decreasing O‐GlcNAcylation. The reduction in O‐GlcNAc levels boosts p53‐driven apoptosis and influences the Akt/GSK3β/mTOR signaling pathway ...
Jaehoon Lee, Byung‐Cheol Han, Gi‐Bang Koo, Jihye Park, Mijin Kwon, Young Bin Park, Jae‐Mun Choi, Seung‐Ho Lee, Sangho Roh   +8 more
wiley   +1 more source

Adaptive estimation of the Gutenberg-Richter b value using a state space model and particle filtering. [PDF]

Sci Rep
Iwata D, Nanjo KZ.
europepmc   +1 more source

Tumor mutational burden as a determinant of metastatic dissemination patterns

Molecular Oncology, EarlyView.
This study performed a comprehensive analysis of genomic data to elucidate whether metastasis in certain organs share genetic characteristics regardless of cancer type. No robust mutational patterns were identified across different metastatic locations and cancer types.
Eduardo Candeal, Andrea Moreno‐Manuel, Miguel Salvadó‐Pertierra, Cristina Santos‐Vivas, Rebeca Sanz‐Pamplona   +4 more
wiley   +1 more source

Single-shot multi-b-value (SSMb) diffusion-weighted MRI using spin echo and stimulated echoes with variable flip angles. [PDF]

NMR Biomed
Dan G, Sun K, Luo Q, Zhou XJ.
europepmc   +1 more source

Diffusion-weighted magnetic resonance imaging in differentiating acute infectious spondylitis from degenerative Modic type 1 change; the role of b-value, apparent diffusion coefficient, claw sign and amorphous increased signal.

British Journal of Radiology, 2016
M. Daghighi, M. Poureisa, Mohsen Safarpour, R. Behzadmehr, D. Fouladi, A. Meshkini, M. Varshochi, A. Kiani Nazarlou   +7 more
semanticscholar   +1 more source

TRAIL‐PEG‐Apt‐PLGA nanosystem as an aptamer‐targeted drug delivery system potential for triple‐negative breast cancer therapy using in vivo mouse model

Molecular Oncology, EarlyView.
Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat, Aslihan Kucuk, Omer Erdogan, Samed Ozer, Bensu Kozan, Tugba Cuceli, Erkan Gumus, Evrim Cevik, Ozge Cevik   +8 more
wiley   +1 more source

Synthesizing High b-Value Diffusion-Weighted Imaging of Gastric Cancer Using an Improved Vision Transformer CycleGAN. [PDF]

Bioengineering (Basel)
Hu C, Bian C, Cao N, Zhou H, Guo B.
europepmc   +1 more source

The PI3Kδ inhibitor roginolisib (IOA‐244) preserves T‐cell function and activity

Molecular Oncology, EarlyView.
Identification of novel PI3K inhibitors with limited immune‐related adverse effects is highly sought after. We found that roginolisib and idelalisib inhibit chronic lymphocytic leukemia (CLL) cells and Treg suppressive functions to similar extents, but roginolisib affects cytotoxic T‐cell function and promotion of pro‐inflammatory T helper subsets to a
Elise Solli, Alessio Bevilacqua, Mathias Wenes, Denis Migliorini, Lars van der Veen, Sigrid S Skånland, Giusy Di Conza, Kjetil Taskén   +7 more
wiley   +1 more source

Feasibility study of computed high b-value diffusion-weighted magnetic resonance imaging for pediatric posterior fossa tumors. [PDF]

Diagn Interv Radiol
Delibalta S, Genç B, Bilgici MC, Aslan K.   +3 more
europepmc   +1 more source

MGH-USC Human Connectome Project datasets with ultra-high b-value diffusion MRI

NeuroImage, 2016
Q. Fan, T. Witzel, A. Nummenmaa, K. V. Dijk, J. D. Horn, Michelle K. Drews, L. Somerville, M. Sheridan, Rosario M. Santillana, Jenna Snyder, T. Hedden, Emily E. Shaw, Marisa O. Hollinshead, V. Renvall, R. Zanzonico, B. Keil, S. Cauley, J. Polimeni, M. Tisdall, R. Buckner, V. Wedeen, L. Wald, A. Toga, B. Rosen   +23 more
semanticscholar   +1 more source