Results 51 to 60 of about 362,885 (283)
Molecular Oncology, EarlyView.We show that the majority of the 18 analyzed recurrent cancer‐associated ERBB4 mutations are transforming. The most potent mutations are activating, co‐operate with other ERBB receptors, and are sensitive to pan‐ERBB inhibitors. Activating ERBB4 mutations also promote therapy resistance in EGFR‐mutant lung cancer.
Veera K. Ojala +15 more
wiley +1 more source
B. F. Skinner: teórico da ciência e teórico da moral?
Arquivos Brasileiros de Psicologia, 2009 Would Skinners moral theory be dependent on his scientific theory to the point of becoming meaningless without it? The mere suggestion of such hypothesis brings the problem of naturalistic fallacy, that is, the problem of deriving statements of "ought ...
Diego Zilio, Kester Carrara
doaj
Análise das propriedades psicométricas da versão portuguesa de um instrumento de avaliação de e-Literacia em Saúde [PDF]
, 2014 Contexto: As fontes de informação eletrónica assumem um papel primordial nos contextos de informação em saúde, tornando-se fontes privilegiadas para toda a população, sobretudo adolescentes. Objetivos: Validar a eHealth Literacy Scale para a população
Ferreira, Teresa +2 more
core +1 more source
Peroxidasin enables melanoma immune escape by inhibiting natural killer cell cytotoxicity
Molecular Oncology, EarlyView.Peroxidasin (PXDN) is secreted by melanoma cells and binds the NK cell receptor NKG2D, thereby suppressing NK cell activation and cytotoxicity. PXDN depletion restores NKG2D signaling and enables effective NK cell–mediated melanoma killing. These findings identify PXDN as a previously unrecognized immune evasion factor and a potential target to improve
Hsu‐Min Sung +17 more
wiley +1 more source
Introduction to Library Trends 50 (1) Summer 2001: Computer-Based Instruction in Libraries and Library Education [PDF]
, 2001 published or submitted for ...
McFadden, Thomas G.
core
Age and gender differences in children's food preferences [PDF]
, 2005 The present study was conducted to examine the developmental patterning of food preferences in a large sample of British schoolchildren and to investigate possible gender differences.
Cooke, LJ, Wardle, J
core +1 more source
Molecular Oncology, EarlyView.Etoposide induces DNA damage, activating p53‐dependent apoptosis via caspase‐3/7, which cleaves PARP1. Dammarenediol II enhances this apoptotic pathway by suppressing O‐GlcNAc transferase activity, further decreasing O‐GlcNAcylation. The reduction in O‐GlcNAc levels boosts p53‐driven apoptosis and influences the Akt/GSK3β/mTOR signaling pathway ...
Jaehoon Lee +8 more
wiley +1 more source
Principales esfuerzos innovadores en la escuela actual
Ciencia y Sociedad, 1977 Este artículo aborda un tema crucial: la actual crisis escolar, los recursos insuficientes y la baja rentabilidad de las inversiones realizadas en educación.
Jorge Max Fernández
doaj +1 more source
A Sentence from B. F. Skinner [PDF]
, 2005 A sentence by Professor B.F. Skinner, 'It occurred to me to go for a walk,' provides an opportunity to give it a framework of quantized subjectivity, as distinct from Skinner's approach of contingent reinforcement.
Stephenson, William
core +1 more source
Tumor mutational burden as a determinant of metastatic dissemination patterns
Molecular Oncology, EarlyView.This study performed a comprehensive analysis of genomic data to elucidate whether metastasis in certain organs share genetic characteristics regardless of cancer type. No robust mutational patterns were identified across different metastatic locations and cancer types.
Eduardo Candeal +4 more
wiley +1 more source