Results 51 to 60 of about 422,420 (292)

Ionomycin suppresses cancer cell growth by disrupting mitochondrial transcription

open access: yesFEBS Open Bio, EarlyView.
In this study, we identify a new function for the selective Ca2+ ionophore, ionomycin, as an inhibitor of mitochondrial transcription. Both total and nascent RNA analyses revealed that ionomycin treatment reduces the transcription of mitochondrial genes.
Lishen Wang   +10 more
wiley   +1 more source

Involvement of pulmonary arteriopathy in the development and severity of reperfusion pulmonary edema after pulmonary endarterectomy

open access: yesPulmonary Circulation, 2019
Reperfusion pulmonary edema (RPE) is a common complication after pulmonary endarterectomy (PEA) in patients with chronic thromboembolic pulmonary hypertension (CTEPH). However, the precise mechanisms underlying the development of RPE remain unclear.
Takayuki Jujo Sanada   +13 more
doaj   +1 more source

Sporočila za javnost: od tradicionalnega k digitalnemu

open access: yesMednarodno Inovativno Poslovanje, 2018
Digitalne tehnologije vnašajo velike spremembe v vse oblike komuniciranja, tudi na polje pisnega komuniciranja, ki velja za eno najpomembnejših kompetenc, ki jih praktiki odnosov z javnostmi potrebujejo pri vsakdanjem delu.
Nada Serajnik Sraka
doaj   +1 more source

Adenosine triphosphate as a modulator of protein interactions and stability

open access: yesFEBS Open Bio, EarlyView.
ATP is best known as the cell's energy currency, but it also shapes how proteins fold, interact, aggregate and form biomolecular condensates. This review explains the emerging physical principles behind these effects, including weak binding to charged protein regions, magnesium‐dependent behaviour and concentration‐dependent control of protein ...
Shuyuan Tan, Robin Curtis
wiley   +1 more source

Dextran sulfate activates contact system and mediates arterial hypotension via B2 kinin receptors [PDF]

open access: yes, 1994
To define some of the mechanisms underlying dextran sulfate (DXS)-induced hypotension, we investigated the effects of either the plasma kallikrein inhibitor des-Pro2-[Arg15] aprotinin (BAY x 4620) or the specific bradykinin B2-receptor antagonist Hoe-140
Siebeck, Matthias   +7 more
core   +2 more sources

Single-Eye Porcine Retinal Pigment Epithelium Cell Cultures—A Validated and Reproducible Protocol

open access: yesBioMed
Background: Age-related macular degeneration (AMD) is the leading cause of severe vision loss in industrialized nations. AMD models based on standardized optimized cell culture models are warranted.
Philipp Dörschmann   +4 more
doaj   +1 more source

Horizon entropy with loop quantum gravity methods

open access: yesPhysics Letters B, 2015
We show that the spherically symmetric isolated horizon can be described in terms of an SU(2) connection and an su(2)-valued one-form, obeying certain constraints.
Daniele Pranzetti, Hanno Sahlmann
doaj   +1 more source

Heterotropic regulation and negative homotropic cooperativity

open access: yesFEBS Open Bio, EarlyView.
We identified a structural module common to some proteins that couple negative cooperativity with heterotropic regulation, two features that rarely coexist. These proteins are ring‐like and present an ordered asymmetry whereby noncontacting subunits are symmetric, and their tertiary structure differs from that of contacting subunits.
Veronica Morea   +5 more
wiley   +1 more source

On Motivation to Apply ODL in Adult Teachers' Education

open access: yesInformatics in Education, 2011
This paper investigates the motivation of teachers of primary education to be trained by means of ODL (Open and Distance Learning). The survey took place during a professional training period and aimed to investigate initially the awareness of the ...
Athanasis KAROULIS
doaj   +1 more source

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