Results 221 to 230 of about 385,065 (234)

B7-1 expression by a non-antigen presenting cell-derived tumor.

Cancer research, 1995
The existence of a naturally occurring immunosurveillance against neoplastic cells is controversial. A difficulty with this concept is that tumor-specific antigen-reactive T cells would not be expected to become activated after encountering tumor cells, since T cells that bind to antigen in the absence of the costimulation provided by antigen ...
S J, Antonia, T, Muñoz-Antonia, G, Soldevila, J, Miller, R A, Flavell   +4 more
openaire   +1 more source

B7-1 antigen expression in tumor cells from cancerous human tissues.

Analytical and quantitative cytology and histology, 2000
To explore the expression of B7-1 antigen (Ag), the most important costimulatory molecule for T-lymphocyte activation, on tumor cells from cancerous human tissues.The study group consisted of 82 biopsies taken from a variety of cancerous human tissues.
L, Si, H, Si, Y, Chen, Y, Sun, Y, Wing
openaire   +1 more source

CD80 (B7-1) and CD86 (B7-2) antigens on house dust mite–specific T cells in atopic disease function through T-T cell interactions

Journal of Allergy and Clinical Immunology, 1999
CD80 (B7-1) and CD86 (B7-2) play an important role in antigen presentation to effector cells. Recent studies have demonstrated that these costimulatory molecules are also expressed on activated T cells. However, the functional role of CD80 and CD86 expressed on allergen-specific T cells in atopic diseases has not yet been clarified.We sought to ...
M, Nakada, K, Nishizaki, T, Yoshino, M, Okano, T, Yamamoto, Y, Masuda, N, Ohta, T, Akagi   +7 more
openaire   +2 more sources

Molecular cloning of the cDNAs encoding the feline B‐lymphocyte activation antigen B7–1 (CD80) and B7–2 (CD86) homologues which interact with human CTLA4‐Ig

European Journal of Immunogenetics, 2000
AbstractWe cloned the cDNAs encoding the feline homologues of B‐lymphocyte activation antigens B7–1 (CD80) and B7–2 (CD86). We expressed recombinant feline CD80 and CD86 molecules by the baculovirus expression system, and demonstrated their binding ability to human CTLA4‐murine immunoglobulin fusion protein.
Y, Nishimura, M, Shimojima, T, Miyazawa, E, Sato, K, Nakamura, Y, Izumiya, Y, Ikeda, T, Mikami, E, Takahashi   +8 more
openaire   +2 more sources

Purification of antigenic peptide from murine hepatoma cells recognized by Class-I major histocompatibility complex molecule-restricted cytotoxic T-lymphocytes induced with B7-1-gene-transfected hepatoma cells

Journal of Hepatology, 1999
It has been reported that expression of costimulatory molecules, such as B7, on tumors is essential for priming tumor-specific cytotoxic T-lymphocytes (CTLs). Here, we have attempted to induce murine hepatoma-specific CTLs by immunizing with the B7-1-gene-expressing hepatoma cells, and to identify the epitope(s) presented on the hepatoma cells.The B7-1-
K, Nakatsuka, H, Sugiyama, Y, Nakagawa, H, Takahashi   +3 more
openaire   +2 more sources

B7-2 expression on tumor cells is important for the acquisition of cytotoxic T lymphocyte activity by spleen cells from low-dose-melphalan-treated MOPC-315 tumor bearers via a mechanism that requires either B7-1 or B7-2 expression on host antigen-presenting cells

Cancer Immunology, Immunotherapy, 2000
We have previously shown that B7-2 (CD86) and, to a lesser extent, B7-1 (CD80) contribute to the curative effectiveness of low-dose melphalan (L-phenylalanine mustard) for mice bearing a large MOPC-315 tumor under conditions that lead to the acquisition of potent cytotoxic T lymphocyte (CTL) activity at the tumor site. Since B7-1 and B7-2 are expressed
D K, Sojka, R N, La Motte, M B, Mokyr
openaire   +2 more sources

Dual expression of human leukocyte antigen molecules and the B7-1 costimulatory molecule (CD80) on human melanoma cells after particle-mediated gene transfer.

Cancer gene therapy, 1996
The aim of this study was to determine if human melanoma cells could be molecularly modified by particle-mediated gene transfer with a "gene gun", using genes for interferon-gamma (IFN-gamma), the B7-1 costimulatory molecule (CD80), and human leukocyte antigen (HLA)-A2, to augment expression of both HLA molecules and B7-1. Established and early passage
M R, Albertini, C A, Emler, K, Schell, K J, Tans, D M, King, M J, Sheehy   +5 more
openaire   +1 more source

Any value of podocyte B7-1 as a biomarker in human MCD and FSGS?

AJP - Renal Physiology, 2016
Rubina Novelli, E. Gagliardini, B. Ruggiero, A. Benigni, G. Remuzzi   +4 more
semanticscholar   +1 more source

Another Piece of the Puzzle of Podocyte B7-1 Expression: Lupus Nephritis

Nephron, 2016
Rubina Novelli, E. Gagliardini, B. Ruggiero, A. Benigni, G. Remuzzi   +4 more
semanticscholar   +1 more source

Crystal structure of the B7-1/CTLA-4 complex that inhibits human immune responses

Nature, 2001
Carin C. Stamper, Yan Zhang, J. Tobin, D. Erbe, S. Ikemizu, S. Davis, M. Stahl, J. Seehra, W. Somers, L. Mosyak   +9 more
semanticscholar   +1 more source