Results 101 to 110 of about 31,066,857 (388)

Inferring processes underlying B-cell repertoire diversity

, 2015
We quantify the VDJ recombination and somatic hypermutation processes in human B-cells using probabilistic inference methods on high-throughput DNA sequence repertoires of human B-cell receptor heavy chains.
Aleksandra M. Walczak, Curtis G. Callan, Dunn-Walters DK, Janeway C, Quentin Marcou, Shapiro GS, Shiokawa S, Stryer L, Thierry Mora, Yuval Elhanati, Zachary Sethna   +10 more
core   +1 more source

MicroRNA-155 influences B-cell function through PU.1 in rheumatoid arthritis [PDF]

, 2016
MicroRNA-155 (miR-155) is an important regulator of B cells in mice. B cells have a critical role in the pathogenesis of rheumatoid arthritis (RA). Here we show that miR-155 is highly expressed in peripheral blood B cells from RA patients compared with ...
Alivernini, Stefano, Benvenuto, Roberta, Canestri, Silvia, Di Mario, Clara, Elmesmari, Aziza, Fedele, Anna Laura, Ferraccioli, Gianfranco, Gigante, Maria Rita, Gremese, Elisa, Kurowska-Stolarska, Mariola, Mangoni, Antonella, McInnes, Iain B., Petricca, Luca, Tolusso, Barbara   +13 more
core   +2 more sources

Decoding the dual role of autophagy in cancer through transcriptional and epigenetic regulation

FEBS Letters, EarlyView.
Transcriptional and epigenetic regulation controls autophagy, which exerts context‐dependent effects on cancer: Autophagy suppresses tumorigenesis by maintaining cellular homeostasis or promotes tumor progression by supporting survival under stress. In this “In a Nutshell” article, we explore the intricate mechanisms of the dual function of autophagy ...
Young Suk Yu, Ik Soo Kim, Sung Hee Baek
wiley   +1 more source

Effects of Exogenous Proteins Injection into the Bursa of Fabricius on Humoral Immunity in Neonatal Chickens

The Journal of Poultry Science, 2012
Early researches have shown that the bursa of Fabricius is a critical organ for development of B lymphocytes in birds. Exogenous proteins from the gut lumen or the environment are taken up by the follicle-associated epithelium and enter into the bursal ...
Fang Yuan, Guojin Wu, Junshuang Gao, Xiaoyan Tang, Zandong Li   +4 more
doaj   +1 more source

B cell regulation in cancer and anti-tumor immunity

Cellular &Molecular Immunology, 2017
The balance between immune effector cells and immunosuppressive cells and how this regulates the tumor microenvironment has been well described. A significant contribution of immune regulatory cells, including regulatory T cells, to tumor progression has
Anushruti Sarvaria, J. A. Madrigal, A. Saudemont   +2 more
semanticscholar   +1 more source

Autophagy in cancer and protein conformational disorders

FEBS Letters, EarlyView.
Autophagy plays a crucial role in numerous biological processes, including protein and organelle quality control, development, immunity, and metabolism. Hence, dysregulation or mutations in autophagy‐related genes have been implicated in a wide range of human diseases.
Sergio Attanasio
wiley   +1 more source

The Impact of Obesity on the Outcomes of Adult Patients with Acute Lymphoblastic Leukemia – A Single Center Retrospective Study

Blood and Lymphatic Cancer: Targets and Therapy, 2021
Qiuju Liu,1 Brittny Major,2 Jennifer Le-Rademacher,2 Aref A Al-Kali,3 Hassan Alkhateeb,3 Kebede Begna,3 Michelle A Elliott,3 Naseema Gangat,3 William J Hogan,3 C Christopher Hook,3 Scott H Kaufmann,3 Animesh Pardanani,3 Mrinal S Patnaik,3 Ayalew Tefferi ...
Liu Q, Major B, Le-Rademacher J, Al-Kali AA, Alkhateeb H, Begna K, Elliott MA, Gangat N, Hogan WJ, Hook CC, Kaufmann SH, Pardanani A, Patnaik MS, Tefferi A, Wolanskyj-Spinner AP, Wei W, Litzow MR   +16 more
doaj  

Protonophore activity of short‐chain fatty acids induces their intracellular accumulation and acidification

FEBS Letters, EarlyView.
The protonated form of butyrate, as well as other short‐chain fatty acids (SCFAs), is membrane permeable. In acidic extracellular environments, this can lead to intracellular accumulation of SCFAs and cytosolic acidification. This phenomenon will be particularly relevant in acidic environments such as the large intestine or tumor microenvironments ...
Muwei Jiang, Frans Bianchi, Geert van den Bogaart   +2 more
wiley   +1 more source

CD19 and POU2AF1 are Potential Immune-Related Biomarkers Involved in the Emphysema of COPD: On Multiple Microarray Analysis

Journal of Inflammation Research, 2022
Da-Wei Zhang,1,2,* Jing-Jing Ye,1,2,* Ying Sun,1,2 Shuang Ji,1,2 Jia-Ying Kang,1,2 Yuan-Yuan Wei,1,2 Guang-He Fei1,2 1Department of Respiratory and Critical Care Medicine, First Affiliated Hospital of Anhui Medical University, Hefei, 230022 ...
Zhang DW, Ye JJ, Sun Y, Ji S, Kang JY, Wei YY, Fei GH   +6 more
doaj  

Allogeneic T Cells That Express an Anti-CD19 Chimeric Antigen Receptor Induce Remissions of B-Cell Malignancies That Progress After Allogeneic Hematopoietic Stem-Cell Transplantation Without Causing Graft-Versus-Host Disease.

Journal of Clinical Oncology, 2016
PURPOSE Progressive malignancy is the leading cause of death after allogeneic hematopoietic stem-cell transplantation (alloHSCT). After alloHSCT, B-cell malignancies often are treated with unmanipulated donor lymphocyte infusions (DLIs) from the ...
Jennifer N. Brudno, R. Somerville, V. Shi, J. Rose, David C. Halverson, D. Fowler, J. Gea-Banacloche, S. Pavletic, D. Hickstein, Tangying Lu, S. Feldman, A. Iwamoto, R. Kurlander, I. Maric, A. Goy, B. Hansen, Jennifer S. Wilder, Bazetta Blacklock-Schuver, F. Hakim, S. Rosenberg, R. Gress, J. Kochenderfer   +21 more
semanticscholar   +1 more source