Results 91 to 100 of about 21,583,992 (313)

LFA-1/ICAM-1 interaction lowers the threshold of B cell activation by facilitating B cell adhesion and synapse formation. [PDF]

, 2004
The integrin LFA-1 and its ligand ICAM-1 mediate B cell adhesion, but their role in membrane-bound antigen recognition is still unknown. Here, using planar lipid bilayers and cells expressing ICAM-1 fused to green fluorescence protein, we found that the ...
Batista, Facundo D, Cameron, T, Dustin, Michael, Dustin, Michael L, Carrasco, YR, Fleire, SJ, Carrasco, Yolanda R, Cameron, Thomas, Batista, FD, Fleire, Sebastian J   +9 more
core   +1 more source

Safety of Daprodustat for the Treatment of Chronic Kidney Disease Anemia: Final Analysis of a Multicenter Postmarketing Surveillance Study in Japan

Therapeutic Apheresis and Dialysis, EarlyView.
ABSTRACT Introduction This final analysis of a multicenter, prospective postmarketing surveillance study evaluated the safety of daprodustat in patients with chronic kidney disease anemia in routine clinical practice in Japan. Methods Patients who initiated daprodustat between September 2020 and July 2022 were registered.
Tadao Akizawa, Kyomi Kanaya, Kiyomi Aizawa, Masanori Onoki, Hirofumi Ozeki, Kazuko Suzuki, Ai Hayashi, Tomohiko Asamura   +7 more
wiley   +1 more source

Alum adjuvant is more effective than MF59 at prompting early germinal center formation in response to peptide-protein conjugates and enhancing efficacy of a vaccine against opioid use disorders

Human Vaccines & Immunotherapeutics, 2019
Opioid use disorders (OUD) and fatal overdoses are a national emergency in the United States. Therapeutic vaccines offer a promising strategy to treat OUD and reduce the incidence of overdose.
Christine Robinson, Carly Baehr, Shirdi E. Schmiel, Claudia Accetturo, Daniel L. Mueller, Marco Pravetoni   +5 more
doaj   +1 more source

Distinct Signaling Requirements for Dμ Selection, IgH Allelic Exclusion, Pre-B Cell Transition, and Tumor Suppression in B Cell Progenitors [PDF]

, 2003
The pre-B cell receptor triggers expansion and differentiation of pre-B cells (the pre-B cell transition), as well as inhibition of VH to DJH recombination (allelic exclusion).
Mutsumi Yamamoto, Ryo Goitsuka, Kitamura, Daisuke, Yamamoto, Mutsumi, Nojima, Takuya, Takuya Nojima, Katsuhiko Hayashi, Daisuke Kitamura, Hayashi, Katsuhiko, Goitsuka, Ryo   +9 more
core   +1 more source

Single-cell genomics identifies distinct B1 cell developmental pathways and reveals aging-related changes in the B-cell receptor repertoire

, 2022
BACKGROUND: B1 cells are self-renewing innate-like B lymphocytes that provide the first line of defense against pathogens. B1 cells primarily reside in the peritoneal cavity and are known to originate from various fetal tissues, yet their developmental ...
Pan, Jiawei, Liu, Xingjie, Zhang, Yu, Liu, Pengtao, Wang, Jing, Li, Mingxia, Zhang, Zhiwei, Luo, Yao, Li, Kairui, Xu, Shasha, Gao, Shaorong, Yu, Yong, Miao, Zhichao, Xu, Xiang   +13 more
core   +1 more source

Enteropathogenic E. coli shows delayed attachment and host response in human jejunum organoid‐derived monolayers compared to HeLa cells

FEBS Letters, EarlyView.
Enteropathogenic E. coli (EPEC) infects the human intestinal epithelium, resulting in severe illness and diarrhoea. In this study, we compared the infection of cancer‐derived cell lines with human organoid‐derived models of the small intestine. We observed a delayed in attachment, inflammation and cell death on primary cells, indicating that host ...
Mastura Neyazi, Pilar Samperio Ventayol, Natalie Burkard, Nicolas Schlegel, Carmen Aguilar, Sina Bartfeld   +5 more
wiley   +1 more source

The Function of Themis2 in B Cells [PDF]

, 2015
Thymocyte-expressed molecule involved in selection 2 (Themis2) is the second member of the Themis family. Recently, the first member of the Themis family, Themis, has been reported to be part of the TCR signalling cascade and its deletion severely ...
Hartweger, H
core  

Profiling the Atlantic Salmon IgM+ B Cell Surface Proteome: Novel Information on Teleost Fish B Cell Protein Repertoire and Identification of Potential B Cell Markers [PDF]

, 2019
Fish immunology research is at a pivotal point with the increasing availability of functional immunoassays and major advances in omics approaches.
Linn G. Tollersrud, Jorunn B. Jørgensen, Jørgensen, Jorunn B., Jack-Ansgar Bruun, Penaranda, Ma Michelle Demogina, Ingvill Jensen, Ma. Michelle D. Peñaranda, Bruun, Jack-Ansgar, Tollersrud, Linn G., Jensen, Ingvill   +9 more
core   +1 more source

Organoids in pediatric cancer research

FEBS Letters, EarlyView.
Organoid technology has revolutionized cancer research, yet its application in pediatric oncology remains limited. Recent advances have enabled the development of pediatric tumor organoids, offering new insights into disease biology, treatment response, and interactions with the tumor microenvironment.
Carla Ríos Arceo, Jarno Drost
wiley   +1 more source

Effect of Cyclophosphamide on miRNA-15a expression in EBV infected transformed B cell

فصلنامه دانشگاه علوم پزشکی جهرم, 2021
Background: Despite advances in diagnosis and therapy of cancer, it is still the main cause of death worldwide. Cyclophosphamide is one of the major drugs for lymphoma treatment.
Abdolreza Sotoodeh Jahromi, Mohammad Kargar, Maliheh Moradzadeh, Farshid Kafilzadeh, Marzieh Jamalidoust   +4 more
doaj