Results 271 to 280 of about 5,727,235 (316)
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Noncanonical B Cells: Characteristics of Uncharacteristic B Cells
The Journal of Immunology, 2023Abstract B lymphocytes were originally described as a cell type uniquely capable of secreting Abs. The importance of T cell help in Ab production was revealed soon afterward. Following these seminal findings, investigators made great strides in delineating steps in the conventional pathway that B cells follow to produce high-affinity Abs.
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FOXO in B-cell lymphopoiesis and B cell neoplasia
Seminars in Cancer Biology, 2018FOX O family transcription factors are important for differentiation and function of multiple cell types. In B lymphocytes they play a critical role. The activity of FOXOs is directly regulated both by signaling from B cell receptor (BCR) and cytokine receptors.
Alexey, Ushmorov, Thomas, Wirth
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“To B or Not to B?” B-Cells and Graft Rejection
Transplantation, 2008There is increasing evidence that various maturational stages of B-cells infiltrate various solid organ transplants undergoing acute rejection. The presence of immature CD20 + and mature CD138 + plasma
Valeriya, Zarkhin +2 more
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Regulation of B-cell commitment to plasma cells or to memory B cells
Seminars in Immunology, 1997During humoral immune responses, B-lymphocyte activation is followed by differentiation along either the plasma cell pathway or the memory B-cell pathway. Recent studies suggest that CD40-CD40 ligand, OX-OX40 ligand, a group of cytokines and intracellular transcriptional factors may all contribute to B-lymphocyte differentiation control.
Y J, Liu, J, Banchereau
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CD5 B Cells, a Fetal B Cell Lineage
1993Publisher Summary This chapter presents a short background of CD5 expression on B cells and focuses on the issue of the relationship of CD5 B cells to B cell development, proposing a model that views this subset as the progeny of a fetal B cell differentiation pathway.
R R, Hardy, K, Hayakawa
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2020
B cell development and activation are accompanied by dynamic genetic alterations including V(D)J rearrangements and immunoglobulin-gene somatic hypermutation and class-switch recombination. Abnormalities in these genetic events can cause chromosomal translocations and genomic mutations, leading to altered expression and function of genes involved in B ...
Xin, Meng, Qing, Min, Ji-Yang, Wang
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B cell development and activation are accompanied by dynamic genetic alterations including V(D)J rearrangements and immunoglobulin-gene somatic hypermutation and class-switch recombination. Abnormalities in these genetic events can cause chromosomal translocations and genomic mutations, leading to altered expression and function of genes involved in B ...
Xin, Meng, Qing, Min, Ji-Yang, Wang
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B-cell receptor regulation of peripheral B cells
Current Opinion in Immunology, 1998Recent studies indicate that immature B cells compete with recirculating B cells for survival signals. The signals, delivered through the B-cell receptor for antigen, induce immature cells to differentiate into recirculating cells and maintain the survival of recirculating cells. They do not induce proliferation or differentiation to antibody-producing
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Blood, 2010
In this issue of Blood , Isnardi and colleagues describe a phenotypically distinct population of autoreactive B cells that have become functionally limited upon stimulation, or “anergic.”[1][1] Importantly, these cells are found at increased frequency in some rheumatoid arthritis patients and ...
Sarah F, Andrews, Patrick C, Wilson
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In this issue of Blood , Isnardi and colleagues describe a phenotypically distinct population of autoreactive B cells that have become functionally limited upon stimulation, or “anergic.”[1][1] Importantly, these cells are found at increased frequency in some rheumatoid arthritis patients and ...
Sarah F, Andrews, Patrick C, Wilson
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European Journal of Immunology, 2006
AbstractPriming of naive lymphocytes is important for yielding efficient immune responses. Mechanisms controlling this process are also important for preventing immune cells from attacking self‐antigens. It is well known that signals provided by innate immune receptors, such as Toll‐like receptors (TLR), are essential to induce dendritic cell ...
Simon, Fillatreau, Rudolf A, Manz
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AbstractPriming of naive lymphocytes is important for yielding efficient immune responses. Mechanisms controlling this process are also important for preventing immune cells from attacking self‐antigens. It is well known that signals provided by innate immune receptors, such as Toll‐like receptors (TLR), are essential to induce dendritic cell ...
Simon, Fillatreau, Rudolf A, Manz
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Rheumatic Disease Clinics of North America, 2004
In recent years, our understanding of B-cell biology and the roles of B cells in normal immune responses and autoimmunity has increased dramatically. We no longer think of B cells simply as antibody factories. It is clear that these diverse and exquisitely regulated cells may contribute in a multitude of ways to immune responses.
Elena, Weinstein +3 more
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In recent years, our understanding of B-cell biology and the roles of B cells in normal immune responses and autoimmunity has increased dramatically. We no longer think of B cells simply as antibody factories. It is clear that these diverse and exquisitely regulated cells may contribute in a multitude of ways to immune responses.
Elena, Weinstein +3 more
openaire +2 more sources