Results 261 to 270 of about 21,583,992 (313)
Erratum: Presentation of Cutaneous Large B-Cell Lymphoma, Leg Type. [PDF]
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The International Journal of Biochemistry & Cell Biology, 2005
B cells are an important component of adaptive immunity. They produce and secrete millions of different antibody molecules, each of which recognizes a different (foreign) antigen. The fact that humans express a very large repertoire of antibodies is due to the complex mechanism of V(D)J recombination of immunoglobulin (Ig) genes as well as other ...
Juha, Ollila, Mauno, Vihinen
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B cells are an important component of adaptive immunity. They produce and secrete millions of different antibody molecules, each of which recognizes a different (foreign) antigen. The fact that humans express a very large repertoire of antibodies is due to the complex mechanism of V(D)J recombination of immunoglobulin (Ig) genes as well as other ...
Juha, Ollila, Mauno, Vihinen
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Science's STKE, 2000
The transcription factor PU.1 is essential in B cell and macrophage development and proliferation. DeKoter and Singh show that the level of expression of PU.1 can control which cell fate will result. At low levels, PU.1 protein caused precursor cells to differentiate into B lymphocytes; whereas at high levels of PU.1, the same cells differentiated into
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The transcription factor PU.1 is essential in B cell and macrophage development and proliferation. DeKoter and Singh show that the level of expression of PU.1 can control which cell fate will result. At low levels, PU.1 protein caused precursor cells to differentiate into B lymphocytes; whereas at high levels of PU.1, the same cells differentiated into
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CD5 B cells and B-cell malignancies
Current Opinion in Hematology, 1999Over the past year, progress has been made in understanding of the physiology and disease associations of CD5+ (B1) B cells, although their exact role in pathogenesis remains unclear. Earlier studies on the negative function of CD5 within the B-cell receptor complex have been substantiated, and it seems likely that soon the signaling pathways used by ...
P M, Lydyard +3 more
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Nature Reviews Immunology, 2023
Recent advances in studies of immune memory in mice and humans have reinforced the concept that memory B cells play a critical role in protection against repeated infections, particularly from variant viruses. Hence, insights into the development of high-quality memory B cells that can generate broadly neutralizing antibodies that bind such variants ...
Takeshi Inoue, Tomohiro Kurosaki
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Recent advances in studies of immune memory in mice and humans have reinforced the concept that memory B cells play a critical role in protection against repeated infections, particularly from variant viruses. Hence, insights into the development of high-quality memory B cells that can generate broadly neutralizing antibodies that bind such variants ...
Takeshi Inoue, Tomohiro Kurosaki
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Noncanonical B Cells: Characteristics of Uncharacteristic B Cells
The Journal of Immunology, 2023Abstract B lymphocytes were originally described as a cell type uniquely capable of secreting Abs. The importance of T cell help in Ab production was revealed soon afterward. Following these seminal findings, investigators made great strides in delineating steps in the conventional pathway that B cells follow to produce high-affinity Abs.
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FOXO in B-cell lymphopoiesis and B cell neoplasia
Seminars in Cancer Biology, 2018FOX O family transcription factors are important for differentiation and function of multiple cell types. In B lymphocytes they play a critical role. The activity of FOXOs is directly regulated both by signaling from B cell receptor (BCR) and cytokine receptors.
Alexey, Ushmorov, Thomas, Wirth
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“To B or Not to B?” B-Cells and Graft Rejection
Transplantation, 2008There is increasing evidence that various maturational stages of B-cells infiltrate various solid organ transplants undergoing acute rejection. The presence of immature CD20 + and mature CD138 + plasma
Valeriya, Zarkhin +2 more
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