Results 291 to 300 of about 31,156,887 (403)
Stromal gene signatures in large-B-cell lymphomas.
New England Journal of Medicine, 2008 G. Lenz, George W. Wright, S. Dave, Wenming Xiao, J. Powell, Huaqing Zhao, Wei Xu, Bruce K. Tan, N. Goldschmidt, J. Iqbal, J. Vose, M. Bast, K. Fu, D. Weisenburger, T. Greiner, J. Armitage, A. Kyle, L. May, R. Gascoyne, J. Connors, G. Trøen, H. Holte, S. Kvaløy, D. Dierickx, G. Verhoef, J. Delabie, E. Smeland, P. Jares, A. Martínez, A. López-Guillermo, E. Montserrat, E. Campo, R. Braziel, T. Miller, L. Rimsza, J. Cook, B. Pohlman, J. Sweetenham, R. Tubbs, R. Fisher, E. Hartmann, A. Rosenwald, G. Ott, G. Ott, H. Müller-Hermelink, D. Wrench, T. Lister, E. Jaffe, W. Wilson, W. C. Chan, L. Staudt +50 moresemanticscholar +1 more sourceComprehensive profiling of lncRNAs and mRNAs enriched in small extracellular vesicles for early noninvasive detection of colorectal cancer: diagnostic panel assembly and extensive validation
Molecular Oncology, EarlyView.Small extracellular vesicles are a promising source of diagnostic molecules. We conducted a comprehensive study, including transcriptome profiling and RT‐qPCR validation on large cohorts of samples. Diagnostic panels enabling sensitive detection of colorectal cancer and precancerous lesions were established. Some molecules were differentially expressed Petra Vychytilova‐Faltejskova, Marketa Pavlikova, Lucie Pifkova, Robin Jugas, Tana Machackova, Lenka Radova, Milana Sachlova, Renata Bartosova, Tetiana Samoilenko, Zuzana Feckova, Jana Orlickova, Erika Slamova, Elleni Ponechal Michu, Dagmar Al Tukmachi, Michaela Ruckova, Martina Vodinska, Jan Kotoucek, Tina Catela Ivkovic, Marie Boudna, Lucia Bohovicova, Teodor Stanek, Jana Halamkova, Martin Svoboda, Vladimir Prochazka, Tomas Grolich, Zdenek Kala, Ondrej Slaby +26 morewiley +1 more sourceβ‐TrCP overexpression enhances cisplatin sensitivity by depleting BRCA1
Molecular Oncology, EarlyView.Low levels of β‐TrCP (Panel A) allow the accumulation of BRCA1 and CtIP, which facilitate the repair of cisplatin‐induced DNA damage via homologous recombination (HR) and promote tumor cell survival. In contrast, high β‐TrCP expression (Panel B) leads to BRCA1 and CtIP degradation, impairing HR repair, resulting in persistent DNA damage and apoptosis ...Rocío Jiménez‐Guerrero, Alejandro Belmonte‐Fernández, Mónica González‐Moreno, Laura Rodríguez‐Cordero, Begoña Pérez‐Valderrama, Joaquín Herrero‐Ruíz, Francisco Romero, Carmen Sáez, Miguel Á. Japón +8 morewiley +1 more sourceRemission Assessment by Circulating Tumor DNA in Large B-cell Lymphoma. [PDF]
J Clin OncolRoschewski M, Kurtz DM, Westin JR, Lynch RC, Gopal AK, Alig SK, Sworder BJ, Cherng HJ, Kuffer C, Blair D, Brown K, Goldstein JS, Schultz A, Close S, Chabon JJ, Diehn M, Wilson WH, Alizadeh AA. +17 moreeuropepmc +1 more sourceThe critical role of DNA damage‐inducible transcript 4 (DDIT4) in stemness character of leukemia cells and leukemia initiation
Molecular Oncology, EarlyView.Stemness properties, including quiescence, self‐renewal, and chemoresistance, are closely associated with leukemia relapse. Here, we demonstrate that DNA damage‐inducible transcript 4 (DDIT4) is induced in the hypoxic bone marrow niche and is essential for maintaining the stemness of AML1‐ETO9a leukemia cells.Yishuang Li, Zhijie Cao, Haiyan Xing, Zhenya Xue, Wenbing Liu, Jiayuan Chen, Yihan Mei, Runxia Gu, Hui Wei, Shaowei Qiu, Min Wang, Qing Rao, Jianxiang Wang +12 morewiley +1 more source