Results 31 to 40 of about 14,694,625 (350)
Experimental Biology and Medicine, 1991 SummaryA major proportion of CD5+ B lymphocytes are committed to the production of a discrete type of antibody that is polyreactive. Polyreactive antibodies appear to use selected V and, perhaps, D gene segments, mostly in unmutated configuration. They generally display relatively low affinity for different antigens and are often part of the primary ...
M T, Kasaian, H, Ikematsu, P, Casali
openaire +2 more sources
17p deletion strongly influences rituximab elimination in chronic lymphocytic leukemia
Journal for ImmunoTherapy of Cancer, 2019 Chronic lymphocytic leukemia (CLL) is the most common type of leukemia and the anti-CD20 monoclonal antibody, rituximab, represents the therapeutic gold standard for more than 2 decades in this pathology, when used in combination with chemotherapy ...
Cristina Bagacean +11 more
doaj +1 more source
JAK Inhibitors and Oxidative Stress Control
Frontiers in Immunology, 2019 Primary Sjögren's syndrome (SjS) is a complex autoimmune epithelitis, with few treatment options, but the use of Janus kinase (JAK) inhibitors is promising because suppression of the JAK/signal transducer and activator of transcription (STAT) pathway ...
Amandine Charras +11 more
doaj +1 more source
Human lymphoma mutations reveal CARD11 as the switch between self-antigen-induced B cell death or proliferation and autoantibody production [PDF]
, 2016 Self-tolerance and immunity are actively acquired in parallel through a poorly understood ability of antigen receptors to switch between signaling death or proliferation of antigenbinding lymphocytes in different contexts.
Domaschenz, Heather +8 more
core +1 more source
Clinical Therapeutics, 2018 PURPOSE The aim of this article was to review published research related to B lymphocytes in rheumatoid arthritis, their role in the pathogenesis of the disease, the effects of tumor necrosis factor (TNF)-α inhibitors on B lymphocytes, the risk for ...
O. Pala +3 more
semanticscholar +1 more source
CD5-Positive B Lymphocytes after Kidney Transplantation
Diagnostics, 2021 Kidney transplantation is the treatment of choice for end-stage kidney diseases. Unfortunately, kidney allograft recipients rarely develop tolerance or accommodation and require life-long immunosuppression.
Maciej Zieliński +9 more
doaj +1 more source
II. Detection of an antigen on resting T cells down-regulated after activation [PDF]
, 1987 The expression of an antigen on porcine T lymphocytes detected by murine monoclonal antibody (mAb) 8/1 was investigated by functional studies and dual-parameter immunofluorescence.
Bühring, Hans-Jörg +4 more
core +1 more source
The effects of splenic irradiation on lymphocyte subpopulations in chronic B-lymphocytic leukemia [PDF]
, 1988 We describe the effect of splenic irradiation (SI) (0,5–1 Gy weekly) on lymphocyte subpopulations for 7 patients with progressive B chronic B-lymphocytic leukemia (B-CLL).
Aabo +24 more
core +3 more sources
Arthritis Research & Therapy, 2017 Background The objective was to evaluate concordance between 2002 American-European Consensus Group (AECG) and 2016 American College of Rheumatology (ACR)/European League Against Rheumatism (EULAR) classification criteria for primary Sjögren’s syndrome ...
Maëlle Le Goff +13 more
doaj +1 more source
Japanese Journal of Clinical Immunology, 2005 Recent studies have revealed that B cells play a critical role in autoimmunity and disease expression through various functions, including autoantibody production, cytokine secretion, antigen presentation, and co-stimulatory effect. Selective targeting of B cells has been recently achieved using a chimeric monoclonal antibody against CD20 (Rituximab ...
openaire +3 more sources