Results 1 to 10 of about 149,839 (140)

Compressed sensing expands the multiplexity of imaging mass cytometry. [PDF]

Nat Commun, 2023
The multiplexity of current antibody-based imaging is limited by the number of reporters that can be detected simultaneously. Compressed sensing can be used to reconstruct high-dimensional information from low-dimensional measurements.
Hosogane T, Santana LS, Eling N, Moch H, Bodenmiller B.   +4 more
europepmc   +4 more sources

Imaging mass cytometry of the immune microenvironment in alveolar echinococcosis. [PDF]

Front Cell Infect Microbiol
BackgroundAlveolar echinococcosis (AE), caused by Echinococcus multilocularis, is a severe parasitic disease exhibiting tumor-like growth and profound immune evasion.
Ma Y, Zhang Y, Zhang T, Zhang L, Wang Z, Yang Z, Guo X, Han J, Hou J, Tian M, Huang D, Wang H, Fan H.   +12 more
europepmc   +3 more sources

Imaging mass cytometry reveals tissue-specific cellular immune phenotypes in the mouse knee following ACL injury. [PDF]

Osteoarthr Cartil Open, 2023
Objective: To develop an imaging mass cytometry method for identifying complex cell phenotypes, inter-cellular interactions, and population changes in the synovium and infrapatellar fat pad (IFP) of the mouse knee following a non-invasive compression ...
South SM, Marlin MC, Mehta-D'souza P, Stephens T, Conner T, Burt KG, Guthridge JM, Scanzello CR, Griffin TM.   +8 more
europepmc   +4 more sources

Dual-modality imaging of immunofluorescence and imaging mass cytometry for whole-slide imaging and accurate segmentation. [PDF]

Cell Rep Methods, 2023
Summary: Imaging mass cytometry (IMC) is a powerful technique capable of detecting over 30 markers on a single slide. It has been increasingly used for single-cell-based spatial phenotyping in a wide range of samples.
Kim EN, Chen PZ, Bressan D, Tripathi M, Miremadi A, di Pietro M, Coussens LM, Hannon GJ, Fitzgerald RC, Zhuang L, Chang YH.   +10 more
europepmc   +2 more sources

An imaging mass cytometry immunophenotyping panel for non-human primate tissues. [PDF]

Front Immunol, 2022
It has recently become clear that spatial organization contributes to cellular function and that expanding our knowledge on cellular organization is essential to further our understanding of processes in health and disease. Imaging mass cytometry enables
Niewold P, Ijsselsteijn ME, Verreck FAW, Ottenhoff THM, Joosten SA.   +4 more
europepmc   +2 more sources

The application of imaging mass cytometry in the immune microenvironment of alveolar echinococcosis. [PDF]

Front Cell Infect Microbiol
BackgroundHepatic alveolar echinococcosis (HAE) is a chronic parasitic disease caused by infection with the larval form of Echinococcus multilocularis, characterised by the formation of invasive lesions in the liver, which involve the proliferation of ...
Shi D, Pang M, Tie C, Fan H.
europepmc   +2 more sources

IMC-Denoise: a content aware denoising pipeline to enhance Imaging Mass Cytometry. [PDF]

Nat Commun, 2023
Multiplexed imaging technologies can reveal the complex cellular and molecular profiles of tissue. Here, the authors develop and implement a denoising pipeline to significantly enhance imaging mass cytometry quality and improve single-cell analyses.
Lu P, Oetjen KA, Bender DE, Ruzinova MB, Fisher DAC, Shim KG, Pachynski RK, Brennen WN, Oh ST, Link DC, Thorek DLJ.   +10 more
europepmc   +2 more sources

From surfing to diving into the tumor microenvironment through multiparametric imaging mass cytometry. [PDF]

Front Immunol
The tumor microenvironment (TME) is a complex ecosystem where malignant and non-malignant cells cooperate and interact determining cancer progression. Cell abundance, phenotype and localization within the TME vary over tumor development and in response ...
Erreni M, Fumagalli MR, Marozzi M, Leone R, Parente R, D'Anna R, Doni A.   +6 more
europepmc   +2 more sources

Imaging mass cytometry dataset of small-cell lung cancer tumors and tumor microenvironments. [PDF]

BMC Res Notes
Objectives Small cell lung cancer (SCLC) accounts for approximately 15% of lung tumors and is marked by aggressive growth and early metastatic spread. In this study, we used two SCLC mouse models with differing tumor mutation burdens (TMB).
Rose F, Ibruli O, Lichius L, Kiljan M, Gozum G, Caiaffa MI, Cai J, Niu LN, Herter JM, Grüll H, Büttner R, Beleggia F, Bosco G, George J, Herter-Sprie GS, Reinhardt HC, Bozek K.   +16 more
europepmc   +2 more sources

A pilot imaging mass cytometry study of cutaneous nerve-immune cell interactions in post-herpetic neuralgia. [PDF]

Front Immunol
Post-herpetic neuralgia (PHN) is a chronic pain condition that persists after shingles and involves dermatome-specific allodynia, disability, and psychological comorbidities. Cutaneous neuroimmune dysregulation is increasingly linked to chronic pain, but
Telang SN, Karrasch JF, Finch PM, Kogias SS, O'Neil TR, Cunningham AL, Harman AN, Drummond PD, Austin PJ.   +8 more
europepmc   +2 more sources