Results 21 to 30 of about 149,839 (140)
Scientific Reports, 2020 Cancer cells release small extracellular vesicles, exosomes, that have been shown to contribute to various aspects of cancer development and progression. Differential analysis of exosomal proteomes from cancerous and non-tumorigenic breast cell lines can
Yousef Risha +3 more
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Frontiers in Immunology, 2021 A 56-year-old male was diagnosed with right lung upper lobe squamous cancer with right hilar and mediastinum lymph node metastasis. After four cycles of neoadjuvant immunochemotherapy, reexamination by computed tomography showed progressive disease of ...
Wenxiao Jia +9 more
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Mass Cytometry Imaging for the Study of Human Diseases—Applications and Data Analysis Strategies
Frontiers in Immunology, 2019 High parameter imaging is an important tool in the life sciences for both discovery and healthcare applications. Imaging Mass Cytometry (IMC) and Multiplexed Ion Beam Imaging (MIBI) are two relatively recent technologies which enable clinical samples to ...
Heeva Baharlou +9 more
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Imaging Mass Cytometry Analysis of immune Checkpoint Inhibitor-Related Pneumonitis: A Case Report
Frontiers in Immunology, 2022 Immune checkpoint inhibitor-related pneumonitis (CIP) is a rare but well-recognized immune-related adverse event (irAE), causes 35% of irAE related deaths.
Yuan Cheng +8 more
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Mass Cytometric Analysis of Early-Stage Mycosis Fungoides
Cells, 2022 Mycosis fungoides (MF) is the most common subtype of cutaneous T-cell lymphoma. Early-stage disease is characterized by superficial infiltrates of small- to medium-sized atypical epidermotropic T lymphocytes that are clonal related.
Nannan Guo +7 more
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Imaging mass cytometry reveals generalised deficiency in OXPHOS complexes in Parkinson’s disease
npj Parkinson's Disease, 2021 Here we report the application of a mass spectrometry-based technology, imaging mass cytometry, to perform in-depth proteomic profiling of mitochondrial complexes in single neurons, using metal-conjugated antibodies to label post-mortem human midbrain ...
Chun Chen +12 more
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Tissue Staining for Imaging Mass Cytometry v1 [PDF]
, 2021 This protocol describes the preparation and staining of human FFPE material for multiplex visualization using Imaging Mass Cytometry (IMC). This protocol uses basic standard immunohistochemical staining techniques. The tissue is incubated with antibodies that have specific affinity for different cells and tissues in the context of a formalin fixed ...
John Herndon +3 more
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High-resolution imaging mass cytometry to map subcellular structures. [PDF]
Nat MethodsImaging mass cytometry (IMC) is a powerful multiplexed imaging technology used to investigate cell phenotypes and spatial organization of tissue in health and disease. The spatial resolution of IMC is presently at 1 µm, enabling the resolution of single cells and large subcellular compartments but not submicrometer intracellular structures.
Bollhagen A +5 more
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MATISSE: a method for improved single cell segmentation in imaging mass cytometry
BMC Biology, 2021 Background Visualizing and quantifying cellular heterogeneity is of central importance to study tissue complexity, development, and physiology and has a vital role in understanding pathologies.
Matthijs J. D. Baars +8 more
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Frontiers in Immunology, 2021 The integrative analysis of tumor immune microenvironment (TiME) components, their interactions and their microanatomical distribution is mandatory to better understand tumor progression.
Roxane Elaldi +12 more
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