Results 31 to 40 of about 141,877 (234)

LOCATOR: feature extraction and spatial analysis of the cancer tissue microenvironment using mass cytometry imaging technologies [PDF]

, 2023
Motivation Recent advances in highly multiplexed imaging have provided unprecedented insights into the complex cellular organization of tissues, with many applications in translational medicine. However, downstream analyses of multiplexed imaging data
Kleftogiannis, Dimitrios, Dimitrios Kleftogiannis, Akslen, Lars Andreas, Lars A Akslen, Ehsani, Rezvan, Inge Jonassen, Rezvan Ehsani, Jonassen, Inge   +7 more
core   +1 more source

Multidimensional profiling of drug‐treated cells by Imaging Mass Cytometry [PDF]

FEBS Open Bio, 2019
In pharmaceutical research, high‐content screening is an integral part of lead candidate development. Measuring drug response in vitro by examining over 40 parameters, including biomarkers, signaling molecules, cell morphological changes, proliferation indices, and toxicity in a single sample,
Bouzekri, Alexandre, Esch, Amanda, Ornatsky, Olga   +2 more
openaire   +3 more sources

Example imaging mass cytometry raw data

, 2023
This imaging mass cytometry (IMC) dataset serves as an example to demonstrate raw data processing and downstream analysis tools. The data was generated as part of the Integrated iMMUnoprofiling of large adaptive CANcer patient cohorts (IMMUcan) project ...
Eling, Nils, Windhager, Jonas
core   +1 more source

Tissue Staining for Imaging Mass Cytometry v1 [PDF]

, 2021
This protocol describes the preparation and staining of human FFPE material for multiplex visualization using Imaging Mass Cytometry (IMC). This protocol uses basic standard immunohistochemical staining techniques. The tissue is incubated with antibodies that have specific affinity for different cells and tissues in the context of a formalin fixed ...
John Herndon, Madelyn Carmody, Stephen Oh, not provided William Gillanders Washington University St Louis   +3 more
openaire   +1 more source

Imaging mass cytometry reveals generalised deficiency in OXPHOS complexes in Parkinson’s disease [PDF]

, 2021
Here we report the application of a mass spectrometry-based technology, imaging mass cytometry, to perform in-depth proteomic profiling of mitochondrial complexes in single neurons, using metal-conjugated antibodies to label post-mortem human midbrain ...
Bone, Laura, Chen, Chun, Filby, Andrew, Vincent, Amy E., McDonald, David, Reeve, Amy K., Warren, Charlotte, Pickett, Sarah J., Turnbull, Doug M., Sachdeva, Ashwin; id_orcid, Smith, Anna L.M., Hudson, Gavin, Blain, Alasdair   +12 more
core   +3 more sources

Enabling Indium Channels for Mass Cytometry by Using Reinforced Cyclambased Chelating Polylysine

, 2020
A metal containing polymer (MCP) based on a polylysine functionalized by In(III) chelates was synthesized. The chelator is based on a constrained dipicolinate cyclam that forms a highly inert In(III) complex.
Raphael, Tripier, Maryline, Beyler, Peng, Liu, Nick, Zabinyakov, olga, ornatsky, Taunia L. L., Closson, Laura, Grenier, Jothir Mayanantham, Pichaandi, Mitchell A., Winnik, Yefeng, Zhang, Alexandre, Bouzekri, Vladimir, Baranov   +11 more
core   +1 more source

IMC antibodies: antibodies used for imaging mass cytometry staining and analysis.

, 2023
IMC antibodies: antibodies used for imaging mass cytometry staining and analysis.
Jordan S. Pober (13913871), Lael Werner (8414109), Blake McCourt (14138703), Shalev Itzkovitz (21721), Fujing Wang (12075455), Tatiana Silva (7419971), Dror Shouval (3436574), Adi Egozi (11547698), Richard W. Pierce (2516263), Xiaojing An (14301042), Liza Konnikova (8771951), Kong Chen (350715), Oluwabunmi Olaloye (14578412)   +12 more
core   +1 more source

Raw tiff images from Imaging Mass Cytometry output of human osteoblasts

, 2021
Raw multi channel tiff images of imaging mass cytometry output to analyse mitochondrial respiratory chain deficiency in human ...
Conor Lawless (11481685), Daniel Hipps (11480110)   +1 more
core   +1 more source

Mass Spectrometry Imaging and Integration with Other Imaging Modalities for Greater Molecular Understanding of Biological Tissues

, 2018
Over the last two decades, mass spectrometry imaging (MSI) has been increasingly employed to investigate the spatial distribution of a wide variety of molecules in complex biological samples.
Siegel, Tiffany Porta, Siegel, T. P., Hamm, G., Bunch, J., Bunch, Josephine, Schwamborn, Kristina, Cappell, J., Hamm, Gregory, Fletcher, John S.,, Fletcher, John S., Cappell, Jo, Schwamborn, K.   +11 more
core   +1 more source

A platinum polymer probe for multiplexed single cell suspension mass cytometry and imaging mass cytometry assays

Chemical Engineering Journal
Daniel Majonis, Mitchell A Winnik
exaly   +2 more sources