Results 81 to 90 of about 14,063,199 (303)
Reprogramming tumor cells with LCOR mRNA nanotherapy to enhance immunotherapy
Molecular Oncology, EarlyView.LCOR (Ligand‐dependent corepressor) mRNA encapsulated in polymeric nanoparticles restores LCOR activity in tumor cells, constraining aggressive tumor cell states and increasing tumor immunogenicity. This reprogramming makes tumor cells more vulnerable to T‐cell attack and enhances their response to immune‐checkpoint immunotherapy.
Gabriel Serra‐Mir +9 more
wiley +1 more source
Age-related changes of apoptotic cell death in human lymphocytes [PDF]
, 2006 Apoptosis seems to be involved in immunosenescence associated with aging. Moreover, in lymphocytes (PBL) of patients with Alzheimer's disease, an increased susceptibility to the apoptotic pathway has been described possibly due to impaired protection of ...
Schindowski, Katharina +3 more
core
, 1980 We have confirmed in man the presence of a subpopulation of B lymphocytes which cannot reexpress their immunological receptors after challenge with antibodies.
P. F. Conte +3 more
core +1 more source
The multifaceted roles of lysosomes in cancer
Molecular Oncology, EarlyView.Lysosomes support cancer cell adaptation by integrating macromolecule degradation and nutrient recycling with nutrient sensing, inter‐organelle communication and immune regulation. These interconnected functions can promote tumour growth, stress tolerance and therapy resistance, while also creating context‐dependent vulnerabilities that may be ...
Jia Li, Kevin M. Ryan
wiley +1 more source
, 2019 Flow cytometry was used to assess MZ B lymphocytes for each group. (A) Each graph shows number of cells per 100,000 lymphocytes. MZ B lymphocytes were defined as HIS57+CD45RA+. (B) Representative flow cytometry data of spleen MZ B lymphocytes.
Natalie M. Bath (6316517) +9 more
core +1 more source
B lymphocytes undergo TLR2-dependent apoptosis upon Shigella infection
, 2022 S.1215-1229Antibody-mediated immunity to Shigella, the causative agent of bacillary dysentery, requires several episodes of infection to get primed and is short-lasting, suggesting that the B cell response is functionally impaired.
Mozeleski, B. +11 more
core +1 more source
USP7 inhibits FOXO1 activity in chronic lymphocytic leukaemia cells enhancing cell survival
Molecular Oncology, EarlyView.CLL cells rely on BCR‐mediated signalling for survival and proliferation in part through suppression of FOXO1. FOXO1 activity is regulated by a plethora of post‐translational modifications including phosphorylation and ubiquitination. We demonstrated that dual inhibition of BCR signalling and the deubiquitinase USP7 activates FOXO1, modulating its ...
Hassan N.B. Almuhanna +8 more
wiley +1 more source
CCR3 and CCR10 mean fluorescence intensity on CD19+ B lymphocytes.
, 2013 Median fluorescence intensity (MFI). Panel A: CCR3+/CCD19+ B lymphocytes; panel B: CCR10+/CCD19+ B lymphocytes. Median values, standard deviations, and statistically significant differences are indicated. Thirty-nine HIV-exposed seronegative individuals (
Sergio Lo Caputo (34832) +17 more
core +1 more source
Novel, cross-restricted, conserved, and immunodominant Cytotoxic T Lymphocyte epitopes in slow progressors in HIV Type 1 infection [PDF]
, 1996 HIV-specific cytotoxic T lymphocytes (CTLs) play an important role in the immune response to HIV infection. Long-term nonprogressors (LTNPs) or slow progressors (SPs) in HIV infection may make qualitatively different CTL responses compared to those ...
KARL McINTYRE +19 more
core +1 more source
B-lymphocytes in the Pathophysiology of Pancreatic Adenocarcinoma
, 2022 Pancreatic adenocarcinoma is highly infiltrated by B lymphocytes but the relevance of these immune cells in tumor development has been surprisingly overlooked until recently.
Della Torre E +5 more
core +1 more source