Results 81 to 90 of about 14,694,625 (350)

Transforming growth factor beta is an important immunomodulatory protein for human B lymphocytes.

Journal of Immunology, 1986
The growth and differentiation of B cells to immunoglobulin (Ig)-secreting cells is regulated by a variety of soluble factors. This study presents data that support a role for transforming growth factor (TGF)-beta in this regulatory process.
J. Kehrl, A. Roberts, L. Wakefield, S. Jakowlew, M. Sporn, A. Fauci   +5 more
semanticscholar   +1 more source

Combining antibody conjugates with cytotoxic and immune‐stimulating payloads maximizes anti‐cancer activity

Molecular Oncology, EarlyView.
Methods to improve antibody–drug conjugate (ADC) treatment durability in cancer therapy are needed. We utilized ADCs and immune‐stimulating antibody conjugates (ISACs), which are made from two non‐competitive antibodies, to enhance the entry of toxic payloads into cancer cells and deliver immunostimulatory agents into immune cells.
Tiexin Wang, Dong Jun Koo, Peter M. Tessier, Greg M. Thurber   +3 more
wiley   +1 more source

Evolution and phylogeny of B lymphocytes

Revista Alergia México, 2016
B lymphocytes are one of the most important cell types involved in the immune response of mammals. The origin and evolution of this cellular type is unknown, but the B lymphocyte bona fide appeared first in fish.
Fabiola Claudio-Piedras, Humberto Lanz-Mendoza   +1 more
doaj   +1 more source

An improved method on stimulated T-lymphocytes to functionally characterize novel and known LDLR mutations. [PDF]

, 2011
The main causes of familial hypercholesterolemia (FH) are mutations in LDL receptor (LDLR) gene. Functional studies are necessary to demonstrate the LDLR function impairment caused by mutations and would be useful as a diagnostic tool if they allow ...
D'Agostino MN, Del Vecchio L, Di Noto R, Di Taranto MD, Fortunato G., Gentile M, Iannuzzi A, Marotta G, Mirabelli P, Raia M, Romano M, Rubba P   +11 more
core   +1 more source

Baff Mediates Survival of Peripheral Immature B Lymphocytes

Journal of Experimental Medicine, 2000
B cell maturation is a very selective process that requires finely tuned differentiation and survival signals. B cell activation factor from the TNF family (BAFF) is a TNF family member that binds to B cells and potentiates B cell receptor (BCR)-mediated
M. Batten, J. Groom, T. Cachero, Fang Qian, P. Schneider, J. Tschopp, J. Browning, F. Mackay   +7 more
semanticscholar   +1 more source

The PI3Kδ inhibitor roginolisib (IOA‐244) preserves T‐cell function and activity

Molecular Oncology, EarlyView.
Identification of novel PI3K inhibitors with limited immune‐related adverse effects is highly sought after. We found that roginolisib and idelalisib inhibit chronic lymphocytic leukemia (CLL) cells and Treg suppressive functions to similar extents, but roginolisib affects cytotoxic T‐cell function and promotion of pro‐inflammatory T helper subsets to a
Elise Solli, Alessio Bevilacqua, Mathias Wenes, Denis Migliorini, Lars van der Veen, Sigrid S Skånland, Giusy Di Conza, Kjetil Taskén   +7 more
wiley   +1 more source

Cytotoxic lymphocytes in B-cell chronic lymphocytic leukemia [PDF]

, 1990
The occurrence of cytotoxic lymphocyte subpopulations (i.e., CD 16+, CD57+ and cytotoxic CD 8+) was studied in the peripheral blood of 18 B-cell chronic lymphocytic leukemia (B-CLL) patients.
A Mittellman, A Verlardi, AC Bloem, B. G. Grooth, CD Platsoucas, CD Platsoucas, D Catovsky, F Hermann, F Lauria, F Lauria, GM Markey, HW Ziegler, I. Segers-Nolten, J. Greve, JA Wolos, KHG Mills, L. W. M. M. Terstappen, LWMM Terstappen, LWMM Terstappen, LWMM Terstappen, LWMM Terstappen, MA Mon de, N Chiorazzi, NE Kay, R Foa, R Foa, S Davis, T Han, T Inoshita, VP Hokland   +29 more
core   +3 more sources

B lymphocytes are essential for the initiation of T cell-mediated autoimmune diabetes: analysis of a new "speed congenic" stock of NOD.Ig mu null mice

Journal of Experimental Medicine, 1996
The T lymphocytes mediating autoimmune destruction of pancreatic beta cells in the nonobese diabetic (NOD) mouse model of insulin-dependent diabetes mellitus (IDDM) may be generated due to functional defects in hematopoietically derived antigen ...
Davidv Serreze, H. Chapman, D. Varnum, M. Hanson, Peter C keifsnyder, S. Richard, S. Fleming, E. Leiter, L. Shultz   +8 more
semanticscholar   +1 more source

[B lymphocyte ontogeny].

Revista alergia Mexico (Tecamachalco, Puebla, Mexico : 1993), 2016
The B cell development from hematopoietic stem cells is a continuous and highly regulated process where multiple differentiation potentials are gradually lost while acquiring lineage specialized functions. At 50 years of the B cell discovery, the current knowledge of its early differentiation largely derive from the isolation and characterization of ...
Juan Carlos Balandrán, Rosana Pelayo Camacho   +1 more
openaire   +2 more sources

Interrogating the immune landscape of microsatellite stable RAS‐mutated colon cancer

Molecular Oncology, EarlyView.
COLOSSUS project RAS‐mutated MSS colon cancer study explored transcriptomics and immune cell density by immunohistochemistry (IHC), Immunoscore (IS), ISIC/TuLIS scores, mutation counts, and detected different prevalences but similar microenvironment composition across immune markers with clinical relevance for future immunotherapy combination ...
Rodrigo Dienstmann, Eduardo García‐Galea, Alice O'Farrell, Zak Kinsella, Maxime Meylan, Florent Petitprez, Ingrid Arijs, Tom Venken, Hari Ps, Adrian Lärkeryd, Ian Miller, Janick Selves, Nadja Meindl‐Beinker, Fiorella Ruiz‐Pace, Elena Élez, Raquel Comas‐Navarro, Frank Lincoln, Dirk Fey, Gift Nyamundanda, Aoife Nolan, Joern Lewin, Raquel Perez‐Lopez, Jonathan Briody, Kathleen Bennett, Walter Kolch, David Matallanas, Alexander Kel, Enrique Arenas, Joaquín Arribas, Bart Ghesquière, Josep Tabernero, Julie Meilleroux, Deborah McNamara, Ray McDermott, Marvin Lim, Mary O'Reilly, Brian Bird, Lisa Stack, Lucia Moloney, Patrick Morris, Keith Egan, Maciej Milewski, Lars Scheuer, Joachim Behringer, Georg Bolz, Ramon Salazar, Cristina Santos, Andrea Ruiz, Orla Casey, Verena Murphy, Matthias Ebert, Livio Trusolino, Diether Lambrechts, Anguraj Sadanandam, Catherine Sautès‐Fridman, Jochen Prehn, Paolo Nuciforo, Jacques Fieschi, Florence Monville, Darran O'Connor, Wolf Fridman, Annette Byrne   +61 more
wiley   +1 more source