Results 301 to 310 of about 692,088 (326)

Vitamin B12 Levels Association with Functional and Structural Biomarkers of Central Nervous System Injury in Older Adults

Annals of Neurology, EarlyView.
At low levels of B12, specifically when bound to transcobalamin for cellular uptake, evidence of slower conductivity in the brain could point toward impaired myelin. At high levels of B12, specifically when bound to the biologically inert transport protein haptocorrin, biomarkers of neurodegeneration appear in the serum, indicating neuroaxonal injury ...
Alexandra Beaudry‐Richard, Ahmed Abdelhak, Rowan Saloner, Simone Sacco, Shivany C. Montes, Frederike C. Oertel, Christian Cordano, Nour Jabassini, Kirtana Ananth, Apraham Gomez, Azeen Keihani, Makenna Chapman, Sree Javvadi, Shikha Saha, Adam Staffaroni, Christopher Songster, Martin Warren, John W. Boscardin, Joel Kramer, Bruce Miller, Joshua W. Miller, Ralph Green, Ari J. Green   +22 more
wiley   +1 more source

Identifying Key Properties That Drive Redox Mediator Activity in Lactiplantibacillus Plantarum

Angewandte Chemie, EarlyView.
Synthesis and isolation of structurally diverse quinones led to defining key physicochemical properties and biochemical interactions that drive type‐II NADH dehydrogenase (Ndh2)‐dependent extracellular electron transfer activity in Lactiplantibacillus plantarum.
Benjamin T. Blackburn, Robyn A. C. Alba, Vladimir O. Porokhin, Rong Cai, Arden Hatch, Soha Hassoun, Caroline M. Ajo‐Franklin, Emily Mevers   +7 more
wiley   +2 more sources

Longitudinal Metabolomics in Amyotrophic Lateral Sclerosis Implicates Impaired Lipid Metabolism

Annals of Neurology, EarlyView.
Objective Amyotrophic lateral sclerosis (ALS) is a fatal neurodegenerative disease characterized by altered metabolome and energy homeostasis, manifesting with body mass index changes and hypermetabolism—both prognostic of disease progression and survival.
Kai Guo, Masha G. Savelieff, Dae‐Gyu Jang, Samuel J. Teener, Lili Zhao, Junguk Hur, Stephen A. Goutman, Eva L. Feldman   +7 more
wiley   +1 more source

A Hypoxia‐Triggered Bioreduction of Hydrophilic Type I Photosensitizer for Switchable In Vivo Photoacoustic Imaging and High‐Specificity Cancer Phototherapy

Angewandte Chemie, EarlyView.
A hydrophilic type I phototherapeutic agent (NanoPcN8O) was developed which selectively responded to hypoxic tumor microenvironments and switched on type I photodynamic and photothermal effects as well as a photoacoustic signal for activatable photoacoustic imaging and tumor phototherapy.
Yuan‐Yuan Zhao, Yihui Xu, Xiaojun Zhang, Zixuan Chen, Heejeong Kim, Xingshu Li, Juyoung Yoon   +6 more
wiley   +1 more source

Bioinspired Cationic Antimicrobial Polymers

Angewandte Chemie International Edition, Accepted Article.
Antibiotics are an essential tool of modern medicine, which is critically endangered by the spread of antimicrobial resistance (AMR). Without effective antibiotics, a number of medical advancements from the last century are in jeopardy, threatening our global public health and leading to a high death toll.
Heliya Javadi, Anne-Catherine Lehnen, Matthias Hartlieb   +2 more
wiley   +1 more source

An Update: Enzymatic Synthesis for Industrial Applications

Angewandte Chemie International Edition, Accepted Article.
Supported by rapid technological advancements, biocatalytic applications have matured into a sustainable, scalable, and cost‐competitive alternatives to established chemical catalysis. This review presents the most recent examples of enzyme‐based solutions for the manufacturing of molecules with extended carbon‐carbon frameworks and multiple ...
Thomas Bayer, Shuke Wu, Radka Snajdrova, Kai Baldenius, Uwe Bornscheuer   +4 more
wiley   +1 more source

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Benefiting others and self: Production of vitamins in plants

Journal of Integrative Plant Biology, 2021
Chuanying Fang, Jie Luo, Mohamed Maher
exaly  

Microbial Cell Factories for Green Production of Vitamins

Frontiers in Bioengineering and Biotechnology, 2021
Yanyan Wang, Dawei Zhang, Valentina Asnaghi   +2 more
exaly  

Functional Roles of B‐Vitamins in the Gut and Gut Microbiome

Molecular Nutrition and Food Research, 2020
Takashi Uebanso, Kazuaki Mawatari
exaly