Results 201 to 210 of about 692,677 (291)
ChemBioChem, EarlyView.L‐Leu‐AMS‐based adenylation domain inhibitors with the modification of 2′‐OH in the adenosine skeleton are synthesized. Coupled with affinity‐based protein profiling of nonribosomal peptide synthetases (NRPSs), their activities toward surfactin‐NRPSs in Bacillus subtilis are evaluated.
Fumihiro Ishikawa +3 more
wiley +1 more source
Diversity of ThDP‐Dependent Enzymes Forming Chiral Tertiary Alcohols
ChemBioChem, EarlyView.Chiral tertiary alcohols are widespread in nature and bioactive compounds; however, their asymmetric synthesis faces several challenges. This review outlines the toolbox of ThDP‐dependent enzymes able to produce tertiary alcohols through the formation of CC bond formation using ketones as acceptor substrates. Herein, the substrate scope, the diversity
Daniela Bjarnesen +4 more
wiley +1 more source
On the Bacillus of Leprosy [PDF]
Journal of the Royal Society of Medicine, 1883 openaire +3 more sources
Mammalian Tolerance to Amino Acid Heterochirality
ChemBioChem, Accepted Article.Organisms use amino acids predominantly in l‐configuration. On the other hand, a series of studies show that a variety of d‐amino acids also occur in mammals and amino acid homochirality is not complete. Mammals de novo synthesize most amino acids with l‐configuration, but serine and aspartate are converted from l‐ to d‐configuration by endogenous ...
Jumpei Sasabe +4 more
wiley +1 more source
ChemBioChem, Accepted Article.Gold(III) organometallic complexes, particularly cyclometalated Au(III) compounds, have emerged as powerful tools in catalysis and bioinorganic chemistry, offering unique reactivity distinct from their Au(I) counterparts. Among their most interesting transformations, C–S cross‐coupling reactions have become a selective strategy for cysteine arylation ...
Sophie R Thomas, Riccardo Bonsignore
wiley +1 more source
ChemBioChem, Accepted Article.Non‐muscle invasive bladder cancer (NMIBC) accounts for 75% of bladder cancer cases, with Bacillus Calmette‐Guérin (BCG) immunotherapy as the gold standard for high‐risk patients. BCG elicits a robust immune response but is limited by adverse effects and resistance. To enhance its efficacy, we developed a trehalose‐based conjugation strategy, tethering
Michael Grimmeisen +10 more
wiley +1 more source
ChemCatChem, EarlyView.The effects of the osmolytes TMAO and sorbitol on the catalytic activity of Candida boidinii formate dehydrogenase are investigated using computational and experimental studies. The osmolytes exert different effects on the inter‐domain fluctuations, solvation, and active site dynamics of the enzyme as well as on the substrate residence times.
Julio A. Perez‐Erviti +7 more
wiley +1 more source
Resistance of Bacillus Endospores to Extreme Terrestrial and Extraterrestrial Environments
Microbiology and Molecular Biology Reviews, 2000 W. Nicholson +4 more
semanticscholar +1 more source
ChemCatChem, EarlyView.Reaction sequence for the synthesis of methylated products through enzymatic decarboxylation of bio‐based hydroxycinnamic acids and subsequent direct methylation of the resulting styrene intermediates without any further isolation and purification steps.
Kamela Myrtollari +6 more
wiley +1 more source
Efficient Singlet Oxygen Monitoring in Aqueous Media Comprising a Polymer‐embedded Eu3+‐Complex
Chemistry – A European Journal, EarlyView.A singlet dioxygen (1O2) sensitive Eu(III) complex embedded in polymer nanoparticles efficiently detects 1O2 in aqueous media by a remarkable increase in Eu3+ luminescence. These particles also adhere to bacteria surfaces, where the cells appear brightly stained in the presence of 1O2 enabling spectroscopic evaluation and easy detection under the ...
Daniel K. Dinga +3 more
wiley +1 more source