Results 211 to 220 of about 63,566 (275)

New Structure Activity Relationship Insight into the Role of the C‐3 Extension on Rifamycin Antimycobacterial Activity

ChemMedChem, EarlyView.
Rifamycin analogues with variably functionalized C‐3 extensions provide new insight into the role of this region for MTb inhibitory activity. In addition to potentially optimizing target engagement, this region can also be used to modulate physicochemical properties, an important consideration for optimizing antimycobacterial activity.
Clinton G. L. Veale, Ewelina Smolarz, Aleksandra Leśniewska, Krystian Pyta, Piotr Przybylski   +4 more
wiley   +1 more source

Drug Discovery Applications of Nitroso (Hetero)Arene Derivatives

ChemPlusChem, EarlyView.
Nitroso (hetero)aromatic compounds are bioactive molecules with antiviral, anticancer, neuroprotective, and antimicrobial properties. This review highlights their mechanisms of action—oxidative stress, DNA damage, and enzyme inhibition—alongside synthesis, structure–activity relationships, and toxicity challenges, offering insight into their ...
Silvia Roscales, Aurelio G. Csáky
wiley   +1 more source

Understanding pathogen transmission on inanimate surfaces: Insights from respiratory fluid droplet composition and drying dynamics

Droplet, EarlyView.
The graphical abstract shows the various phenomena the droplet undergo during evaporation, precipitation, and transfer to susceptible host. Abstract This study investigates how pathogen‐laden respiratory droplets transfer diseases via inanimate surfaces.
Abdur Rasheed, Kirti Parmar, Jason Joy Poopady, Siddhant Jain, Dipshikha Chakravortty, Saptarshi Basu   +5 more
wiley   +1 more source

1,3‐Diazetidin‐2‐Ones: Synthetic Approaches and Therapeutic Promise within the Aza‐β‐Lactam Family

European Journal of Organic Chemistry, EarlyView.
This review explores the synthesis, reactivity, and therapeutic potential of 1,3‐diazetidin‐2‐ones—an underexplored class of aza‐β‐lactams. Emphasis is placed on synthetic challenges, emerging methodologies, and their promise as β‐lactamase‐resistant scaffolds in medicinal chemistry. 1,3‐diazetidin‐2‐ones, overlooked members of the aza‐β‐lactam family,
Jozef Kristek, Jiří Pospíšil
wiley   +1 more source

MXenes: Emerging Materials for Environmental Biochemical Sensing Platforms

Electron, EarlyView.
MXenes (e.g., transition metal carbides, nitrides, and carbonitrides), among those potential candidates for sensing materials, show promising potential with their intrinsically two‐dimensional large interactive area, wide‐range‐tunable material properties, active surface chemistry, and excellent processability for large‐scale fabrication.
Min Gao, Ran Xiong, Xiangyu Chen, Tse‐Lun Chen, Zesen Zhang, Aiwen Wang, Kun Wang, Mingliang Jin, Zhijun Zhao, Chuanfang (John) Zhang, Jing Wang   +10 more
wiley   +1 more source

Microbial decolorization of a textile azo dye Novacron Blue by natural inhabitant bacteria

Environmental Progress &Sustainable Energy, EarlyView.
Abstract Azo dye discharged in wastewater streams from textile or other industry without treatment results in environmental pollution. This study attempts to uncover the ability of naturally occurring bacteria in reducing and decolorizing a textile azo dye Novacron Blue in nutrient medium and also from textile dye effluent.
Jannatul Ferdousi, Tasneem Chowdhury, Md. Imranul Hoq   +2 more
wiley   +1 more source

Autophagy‐Targeting Nanomedicine: Strike at the Heart of the Cancer via Precise Modulation of Autophagy

Exploration, EarlyView.
This review emphasizes the critical role of autophagy in cancer treatment, highlighting the development of autophagy‐targeting nanomedicines and their applications in combination therapies. It explores how nanoplatforms can effectively regulate autophagy, underscoring the potential of integrating autophagy modulation with other treatment strategies to ...
Zhouyi Sun, Huali Zuo, Kai Zhang, Yang Liu, Qianwen Wang, Qitao Hu, Jiwei Qian, Andreas Lundqvist, Bo Zhang, Weiyu Chen, Zhe Tang   +10 more
wiley   +1 more source

Emerging Techniques for the Recovery of Bioactive Compounds From Sweet Potato Leaves [Ipomoea batatas (L.) Lam] and Their Functional Health Benefits

Food Bioengineering, EarlyView.
Emerging green extraction techniques are revolutionizing the recovery of bioactive compounds from sweet potato (Ipomoea batatas [L.] Lam) leaves. These approaches enhance the yield and stability of key phytochemicals like caffeoylquinic acids, flavonoids, and polyphenols, which offer potent antioxidants, anti‐inflammatory, and metabolic health benefits.
M. H. A. Jahurul, S. Islam
wiley   +1 more source

Research Progress Based on SpyTag/SpyCatcher Self‐Assembling Peptides and Their Applications in the Food Field

Food Bioengineering, EarlyView.
The formation of isopeptide bonds in the SpyTag/SpyCatcher system and its application in the food field ABSTRACT The SpyTag/SpyCatcher system is a modular protein assembly tool based on isopeptide bond‐mediated covalent conjugation, distinguished by mild reaction conditions, rapid ligation rate, and independence from exogenous enzymes or chemical ...
Meng‐meng Cai, Zi‐fu Ni, Zhong‐ke Sun, Xiao‐long Li, Zi‐hao Wang, Min Zhang, Cheng‐wei Li   +6 more
wiley   +1 more source

Marine Algae‐Derived Bioactives: A Sustainable Resource for the Food and Agriculture Industries

Food Frontiers, EarlyView.
Algae are widely used in food and agriculture due to their bioactive compounds and are an eco‐friendly natural preservative and low carbon farming method. However, the problems regarding safety and acceptance still remain as tools like nanotechnology make improvements.
Sara Chadorshabi, Maryam Mohammadi, Ehsan Shamloo, Maryam Mahmoudzadeh   +3 more
wiley   +1 more source