Results 241 to 250 of about 3,197,299 (316)

Insulin Resistance: An Update on Biochemical and Pathophysiological Mechanisms and Impact on Various Diseases

open access: yesiNew Medicine, EarlyView.
ABSTRACT Insulin resistance is the biological phenomenon in which the human body's normal response to the metabolic hormone insulin is compromised. Insulin is a regulator of most of the essential metabolic steps in the body that control energy homoeostasis, so dysregulation leads to multiple diverse human diseases including, most prominently, Type 2 ...
Peter J. Little   +12 more
wiley   +1 more source

Gut microbiome‐derived metabolites show promise in cancer research and therapy

open access: yesInterdisciplinary Medicine, EarlyView.
The metabolites produced by the gut microbiome, which are subject to regulation by multiple factors, play a pivotal role in the progression of various types of cancer. These metabolites not only function as potential biomarkers for the early detection and monitoring of tumor development, but also actively participate in cancer therapeutic processes ...
Kangjie Yang   +4 more
wiley   +1 more source

Intratumoral bacteria engineered for tumor therapy

open access: yesInterdisciplinary Medicine, EarlyView.
This article comprehensively reviews engineered intratumoral bacteria used in tumor therapy. The concept development, characteristics, and engineering methods of intratumoral bacteria are summarized. The mechanisms and the translational significance by which engineered intratumoral bacteria interfere with tumor progression are discussed and highlighted.
Huajie Zhang   +7 more
wiley   +1 more source

A dendrimer enhanced CRISPR/Cas12a performance for the evaluation of acidogenic capacity in cariogenic bacteria

open access: yesInterdisciplinary Medicine, EarlyView.
A CRISPR/Cas12a‐powered dendritic DNA nanostructure is assembled to create confined enzymatic microdomains, enabling ultrasensitive detection. Integrated into a paper‐based origami biosensor, it allows equipment‐free on‐site quantification of acidogenic pathogens for the early diagnosis of dental caries.
Yuan Zhang   +4 more
wiley   +1 more source

Shaping the Aquatic Microbiome: Bacillus Probiotics Drive Community Succession and Enhance Nitrogen Cycling in Litopenaeus vannamei Culture Water

open access: hybrid
Khibar Syiar Moehammad   +6 more
openalex   +1 more source

Diagnostic Performance of Comprehensive Point‐of‐Care Ultrasound for Pediatric Tuberculosis in Spain: A Prospective Observational Study

open access: yesJournal of Clinical Ultrasound, EarlyView.
In children with presumptive tuberculosis, comprehensive point‐of‐care (cPOCUS) identified key thoracic abnormalities with high specificity and excellent inter‐reader reliability. Although diagnostic sensitivity was modest and examinations often incomplete, cPOCUS shows promise as a complementary, radiation‐free imaging tool.
Isabelle Munyangaju   +17 more
wiley   +1 more source

Deep Learning Integration in Optical Microscopy: Advancements and Applications

open access: yesMicroscopy Research and Technique, EarlyView.
It explores the integration of DL into optical microscopy, focusing on key applications including image classification, segmentation, and computational reconstruction. ABSTRACT Optical microscopy is a cornerstone imaging technique in biomedical research, enabling visualization of subcellular structures beyond the resolution limit of the human eye ...
Pottumarthy Venkata Lahari   +5 more
wiley   +1 more source

Impacts of Biostimulants on Nitrous Oxide Emissions and the Soil Microbiome

open access: yesJournal of Plant Nutrition and Soil Science, EarlyView.
Soil incubation experiment examining the influence of biostimulants on greenhouse gas emissions and the soil microbiome in fertilized soils. ABSTRACT Background Overapplication of nitrogenous fertilizer and enhanced microbial activity in agricultural soils are drivers of increasing greenhouse gas emissions.
Conor Blunt   +4 more
wiley   +1 more source

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