Results 51 to 60 of about 570,010 (309)

A novel quinazolinone insulin receptor inhibitor and its synergy with an EGFR inhibitor in glucose‐driven glioblastoma

Molecular Oncology, EarlyView.
The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka, Wioleta Cieślik, Wojciech Płaziński, Katarzyna Stępnik, Anna Boguszewska‐Czubara, Elżbieta Kot, Robert Musioł, Mateusz Jasica, Anna Mrozek‐Wilczkiewicz, Katarzyna Malarz   +9 more
wiley   +1 more source

Screen printable, non-fire-through copper paste applied as busbar metallization for back contact solar cells [PDF]

, 2022
Dominik Rudolph, Rüdiger Farneda, Tudor Timofte, Andreas Halm, Ning Chen, Joris Libal, Florian Buchholz, Isaac Rosen, Michael Grouchko, Ofer Shochet   +9 more
openalex   +1 more source

ZW4864‐mediated inhibition of the β‐catenin/BCL9/BCL9L complex reveals therapeutic potential in bladder cancer

Molecular Oncology, EarlyView.
BCL9 and BCL9L drive bladder cancer progression by enhancing β‐catenin signaling, promoting proliferation, migration, invasion, and organoid growth. Genetic depletion of BCL9(L) suppresses malignant phenotypes, while pharmacological disruption of the β‐catenin/BCL9(L) complex with ZW4864 inhibits canonical Wnt signaling and tumor‐associated cellular ...
Roland Kotolloshi, Mandy Berndt‐Paetz, Eileen Lerner, Gregoire Najjar, Anca Azoitei, Krishna Pal Singh, Shailendra Kumar Gupta, Olaf Wolkenhauer, Cagatay Günes, Otmar Huber, Marc‐Oliver Grimm, Daniel Steinbach   +11 more
wiley   +1 more source

Single‐cell DNA methylation profiling: Technologies, computation, and applications in precision oncology

Molecular Oncology, EarlyView.
Single‐cell DNA methylation (scDNAme) profiling maps epimutational clonal evolution, revealing mechanisms of malignancy and therapeutic resistance across diverse cancer types. By providing a high‐resolution landscape of intratumoral heterogeneity, these technologies empower precise patient stratification, guide the development of enhanced ...
Ik Soo Kim
wiley   +1 more source

Investigation of the curved trajectory formation mechanism of a curling stone focusing on the contact area with ice

Nihon Kikai Gakkai ronbunshu
In the sport of curling, various mechanisms in curl of rotating stones have been proposed; however, the essential understanding of the mechanism has not been clarified.
Yoshiki KAWANO, Yohei HOSHINO, Takao KAMEDA   +2 more
doaj   +1 more source

Single‐molecule DNA flow‐stretch assays for high‐throughput DNA–protein interaction studies

FEBS Open Bio, EarlyView.
We describe an optimised single‐molecule DNA flow‐stretch assay that visualises DNA–protein interactions in real time. Linear DNA fragments are tethered to a surface and stretched by buffer flow for fluorescence imaging. Using λ and φX174 DNA, this protocol enhances reproducibility and accessibility, providing a versatile approach for studying diverse ...
Ayush Kumar Ganguli, Mohammad Nour Alsamsam, Ugnė Bagdonaitė, Van Truc Vu, Chun‐Jen Huang, Polina Kuzhir, Mindaugas Zaremba, Aurimas Kopūstas, Marijonas Tutkus   +8 more
wiley   +1 more source

Back-contact perovskite light-emitting diodes

AIP Advances
Light-emitting diodes utilizing halide perovskites have experienced rapid advancements in recent years, demonstrating notable external quantum efficiencies. Despite these strides, the practical implementation of such devices remains constrained.
Hryhorii P. Parkhomenko, Askhat N. Jumabekov   +1 more
doaj   +1 more source

Back-contact configuration energizes perovskite photovoltaic modules

Nano Research Energy
In this viewpoint, recent hot topics in the photovoltaic community, interdigitated back contact (IBC) cells, are systematically reviewed from the view of device configuration. Two categories of IBC designs on the most popular perovskite solar cells (PSCs)
Xiaoyu Yang, Yongguang Tu, Fengjun Ye, Zheng Bao   +3 more
doaj   +1 more source

Analysing the significance of small conformational changes and low occupancy states in serial crystallographic data

FEBS Open Bio, EarlyView.
This protocol paper outlines methods to establish the success of a time‐resolved serial crystallographic experiment, by means of statistical analysis of timepoint data in reciprocal space and models in real space. We show how to amplify the signal from excited states to visualise structural changes in successful experiments.
Jake Hill, Yelyzaveta Pulnova, Elke De Zitter, Helen M. Ginn, Briony A. Yorke   +4 more
wiley   +1 more source

Influence of Front and Back Contacts on Photovoltaic Performances of p-n Homojunction Si Solar Cell: Considering an Electron-Blocking Layer

International Journal of Photoenergy, 2017
In this simultion work, the effect of front and back contacts of p-n homojunction Si solar cell with an electron-blocking layer (EBL) has been studied with the help of a strong solar cell simulator named AMPS-1D (analysis of microelectronic and photonic ...
Md. Feroz Ali, Md. Faruk Hossain
doaj   +1 more source