Results 121 to 130 of about 2,608,665 (304)

On the dynamics of mechanical failures in magnetized neutron-star crusts

, 2012
We consider the dynamics of a mechanical failure induced by a shear stress in a strongly magnetized neutron-star crust. We show that even if the elastic properties of the crust allow the creation of a shear crack, the strongly sheared magnetic field ...
Ashby, Blaes, Bridgeman, Chamel, Chugunov, Goldreich, Horowitz, Jones, Kostrov, Landau, Levin, Link, Lyutikov, Lyutikov, Maxim Lyutikov, Molinari, Perna, Pons, Thompson, Thompson, Woods, Yuri Levin   +21 more
core   +1 more source

Raman‐based label‐free microscopic analysis of the pancreas in living zebrafish larvae

FEBS Open Bio, EarlyView.
Forward stimulated Raman scattering (F‐SRS) and epi coherent anti‐Stokes Raman scattering (E‐CARS) allow label‐free discrimination of distinct subcellular structures in the pancreas of living zebrafish larvae. Given the straightforward applicability, we anticipate broad implementation of Raman microscopy in other organs and across various biomedical ...
Noura Faraj, Eline M. F. de Lange, Klaas A. Sjollema, Ben N. G. Giepmans   +3 more
wiley   +1 more source

dUTPase is essential in zebrafish development and possesses several single‐nucleotide variants with pronounced structural and functional consequences

FEBS Open Bio, EarlyView.
dUTPases are involved in balancing the appropriate nucleotide pools. We showed that dUTPase is essential for normal development in zebrafish. The different zebrafish genomes contain several single‐nucleotide variations (SNPs) of the dut gene. One of the dUTPase variants displayed drastically lower protein stability and catalytic efficiency as compared ...
Viktória Perey‐Simon, Angéla Békesi, Latifa Kazzazy, Jázmin Mihály, Máté Varga, Beáta G. Vértessy, Kinga Nyíri   +6 more
wiley   +1 more source

Multi‐omics and low‐input proteomics profiling reveals dynamic regulation driving pluripotency initiation in early mouse embryos

FEBS Open Bio, EarlyView.
Mouse pre‐implantation development involves a transition from totipotency to pluripotency. Integrating transcriptomics, epigenetic profiling, low‐input proteomics and functional assays, we show that eight‐cell embryos retain residual totipotency features, whereas cytoskeletal remodeling regulated by the ubiquitin‐proteasome system drives progression ...
Wanqiong Li, Xi Xiao, Lingbin Qi, Chanyi Li, Sirui Song, Jiaying Qin, Zhigang Xue, Jinfeng Xue, Huaifang Li   +8 more
wiley   +1 more source

Screening and epitope characterization of Nidogen‐2‐specific nanobodies

FEBS Open Bio, EarlyView.
Camel immunization and phage display were employed to generate high‐affinity VHH nanobodies against Nidogen‐2. After library construction, biopanning, ELISA screening, sequencing, and recombinant expression, selected nanobodies were purified and characterized, leading to the preliminary exploration of a nanobody‐based sandwich ELISA for specific ...
Jianchuan Wen, Qianqian Cui, Zhongyun Lan, Yingjun Wang, Shuaiying Zhao, Wenxuan Feng, Yunfeng Liu, Qiting Huang, Dongna Zhang, Jianfeng Xu   +9 more
wiley   +1 more source

Magnitude of low back pain and associated factors among primary school teachers in Borama City, Somaliland: an institutional-based cross-sectional study

BMJ Open
Objectives The goal of the study was to determine the magnitude and contributing factors of low back pain among primary school teachers in Borama Town, Somaliland.Design An institution-based descriptive cross-sectional study design was employed.
Seid Yimam Ali, Mekonin Meskelu Shegere, Ahmed Moumin Abdilahi, Najah Bouh Farah, Bilan Abdi Adem, Asma Jemal Nour   +5 more
doaj   +1 more source

Iron homeostasis disruption and lipid peroxidation in skeletal muscle during short‐term immobilization

FEBS Open Bio, EarlyView.
14‐day casting‐induced immobilization reduced gastrocnemius muscle mass and increased non‐heme iron and ferritin heavy chain levels. Despite iron accumulation, transferrin receptor 1 and iron regulatory protein 2 were paradoxically upregulated. Lipid peroxidation was elevated without compensatory antioxidant responses.
Haruka Yokogawa, Kazuhiko Higashida, Naoya Nakai   +2 more
wiley   +1 more source

Proteasomal degradation of intracellularly expressed Amblyomin‐X limits suicide gene therapy potential in melanoma cells

FEBS Open Bio, EarlyView.
This study explores the feasibility of expressing the antitumoral protein Amblyomin‐X through a suicide gene therapy approach and investigates its intracellular fate after gene delivery. Although the gene is efficiently expressed, melanoma cells rapidly degrade the Amblyomin‐X protein via proteasome activity.
Victor Dal Posolo Cinel, Carlos DeOcesano Pereira, Aline Ramos Maia Lobba, Melissa Regina Fessel, Ana Marisa Chudzinski‐Tavassi   +4 more
wiley   +1 more source

Heterostructures impacting deformation strengthening processes in QP steels: Investigating the interplay of grain rotation, slip transfer, and back stress strengthening

Journal of Materials Research and Technology
QP (Quenching and Partitioning) steel, the third generation of advanced high-strength steel, has garnered significant attention due to its exceptional mechanical performance.
Yao Zhou, Weijie Wu, Jinxu Li
doaj   +1 more source

A "God-forsaken" wilderness? : the effects of isolation on the development of rural religion in the Wanganui hinterland, 1880-c1920 : a thesis presented in partial fulfilment of the requirements for the degree of Master of Arts in Religious Studies at Massey University [PDF]

, 1998
Government policy after 1880 was to open up the Wanganui hinterland for settlement. Building of the Main Trunk railway greatly facilitated this. New villages sprang up along the route.
Attwell, Bruce Tristan
core